A5050078795- Asthma and respiratory diseases
- Dermatology and Skin Diseases
- IL-33, ST2, and ILC Pathways
- Numerical methods in engineering
- Immune Cell Function and Interaction
- Allergic Rhinitis and Sensitization
- MicroRNA in disease regulation
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Electromagnetic Simulation and Numerical Methods
- Urticaria and Related Conditions
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Immune Response and Inflammation
- Advanced Numerical Methods in Computational Mathematics
- Cancer, Hypoxia, and Metabolism
- Psoriasis: Treatment and Pathogenesis
- Electromagnetic Scattering and Analysis
- Cardiac Ischemia and Reperfusion
- Pelvic floor disorders treatments
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Adipose Tissue and Metabolism
- Extracellular vesicles in disease
- Autophagy in Disease and Therapy
- T-cell and B-cell Immunology
Karolinska Institutet
2018-2025
Fudan University
2016-2025
Dalian Medical University
2017-2025
Chongqing Medical University
2017-2025
Second Affiliated Hospital of Chongqing Medical University
2017-2025
Kunming Medical University
2023-2025
Macau University of Science and Technology
2024
Ningxia Medical University
2022-2024
Peking University First Hospital
2018-2024
Peking University
2017-2024
Abstract Cancer-associated fibroblasts (CAF) are components of the tumor microenvironment whose contributions to malignant progression not fully understood. Here, we show that fibroblast activation protein (FAP) triggers induction a CAF subset with an inflammatory phenotype directed by STAT3 and inflammation-associated expression signature marked CCL2 upregulation. Enforcing FAP in normal was sufficient endow them similar FAP+CAFs. We identified as persistent activator fibroblastic through...
Abstract Background and Aims We previously demonstrated that cancer‐associated fibroblasts (CAFs) promote tumor growth through recruitment of myeloid‐derived suppressor cells (MDSCs). 5‐lipoxygenase (5‐LO) is highly expressed in myeloid critical for synthesizing leukotriene B4 (LTB4), which involved progression by activating its receptor type 2 (BLT2). In this study, we investigated whether how CAFs regulate MDSC function to enhance cancer stemness, the driving force aggressiveness...
Neutrophils are increasingly recognized as key players in the tumor immune response and associated with poor clinical outcomes. Despite recent advances characterizing diversity of neutrophil states cancer, common trajectories mechanisms governing ontogeny relationship between these remain undefined. Here, we demonstrate that immature mature neutrophils enter tumors undergo irreversible epigenetic, transcriptional, proteomic modifications to converge into a distinct, terminally differentiated...
Thymic stromal lymphopoietin (TSLP) is a cytokine expressed by epithelial cells, including keratinocytes, and important in allergic inflammation. Allergic skin inflammation elicited epicutaneous immunization of mice with ovalbumin (OVA), potential model atopic dermatitis, was severely impaired TSLPR(-/-) mice, as evidenced decreased infiltration eosinophils local expression T helper 2 (Th2) cytokines. However, secretion Th2 cytokines splenocytes from sensitized response to OVA normal. Skin...
IL-17 has been implicated in a number of inflammatory diseases, but the conditions antigen exposure that drive generation Th17 responses have not well defined. Epicutaneous (EC) immunization mice with ovalbumin (OVA), which causes allergic skin inflammation many characteristics lesions atopic dermatitis, was found to also expression skin. EC, i.p., OVA drove IL-17-producing T cells draining lymph nodes and spleen increased serum levels. inhalation by EC-sensitized induced CXCL2 neutrophil...
Chemerin is present in various inflammatory sites and closely involved tissue inflammation. Recent studies have demonstrated that chemerin treatment can cause either anti-inflammatory or pro-inflammatory effects according to the disease model being investigated. Elevated circulating was recently found patients with bowel (IBD); however, role of intestinal inflammation remains unknown. In this study, we administration exogenous (aa17–156) aggravated severity dextran sulfate sodium...
Regulatory T cells (Tregs) and B present in gut-associated lymphoid tissues (GALT) are both implicated the resolution of colitis. However, how functions these coordinated remains elusive. We used dextran sulfate sodium (DSS)-induced colitis model combined with gene-modified mice to monitor progression colitis, simultaneously examine number Tregs cells, production IgA antibodies. found that DSS-treated exhibited more severe absence adoptive transfer attenuated disease. Moreover, IL-10−/− also...
Although obesity is associated with low-grade inflammation and metabolic disorders, clinical studies suggested some obese people were metabolically healthy smaller adipocyte size compared abnormal (MAO). This indicated may be an important predictor underlay the distinction between MAO obese. As recent study has shown that adipocytes expressed class II major histocompatibility complex (MHCII), which functioned as APCs during obesity. However, relationship hypertrophy MHCII expression was not...
Atopic dermatitis (AD) is a Th2-dominated inflammatory skin disease characterized by epidermal thickening. Serum levels of IL-22, cytokine known to induce keratinocyte proliferation, are elevated in AD, and Th22 cells infiltrate AD lesions. We show that application antigen mouse subjected tape stripping, surrogate for scratching, induces an IL-22 response drives hyperplasia proliferation model inflammation shares many features AD. DC-derived IL-23 act on CD4+ T production. However, the...
Abstract New therapeutic options for patients with ovarian cancer are urgently needed. Therefore, we evaluated the efficacy of two second-generation mesothelin (MSLN)-directed CAR T cells in orthotopic mouse models cancer. Treatment expressing an MSLN construct including CD28 domain (M28z) significantly prolonged survival, but no persistent tumor control was observed. Despite lower response rates, MSLN-4–1BB (MBBz) induced long-term remission some SKOV3–bearing mice. Tumor-infiltrating M28z...
Perineural invasion (PNI) and autophagy are two common features in the tumor microenvironment of pancreatic cancer (PanCa) have a negative effect on prognosis. Potential mediator cells molecular mechanism underlying their relationships need to be fully elucidated.To investigate Schwann (SCs) PNI, we reproduced PNI by collecting clinical tissue, performing sciatic nerve injection nude mice with establishing Dorsal root ganglion (DRG) coculture system cell lines. Autophagy was detected IHC,...
Background Limited persistence of functional CAR T cells in the immunosuppressive solid tumor microenvironment remains a major hurdle successful translation cell therapy to treat tumors. Fine-tuning activation by mutating CD3ζ chain immunoreceptor tyrosine-based motifs (ITAMs) CD19-CAR (containing CD28 costimulatory domain) has proven extend preclinical models B malignancies. Methods In this study, two conventional second-generation MSLN-CAR constructs encoding for either co-stimulatory...
Abstract Background Low-quality sleep and obstructive apnea (OSA) can result in series of chronic diseases. Healthy diet has been considered as an effective simple strategy to optimize quality. However, current evidence on the correlation dietary composite antioxidant intake with health remained obscure. Aim study To determine relationship index (CDAI) health. Methods Cross-sectional analyses were based National Health Nutrition Examination Survey (NHANES) 2005–2008. Dietary consumption was...
Pyruvate kinase M2 (PKM2) is a member of the pyruvate family. Recent work has defined "non-metabolic" functions PKM2. However, role PKM2 in HCC remains unclear. To investigate tumor growth, invasion and prognosis hepatocellular carcinoma (HCC), expression was measured cell lines tissues using qRT-PCR, western blot, immunofluorescence assays. In vitro experiments, knocked down short hairpin RNA lentivirus vector, behavior downstream signaling pathways chemokine were analyzed. For analysis...
The lack of effective treatments against the 2019 coronavirus disease (COVID-19) has led to exploratory use convalescent plasma for treating COVID-19. Case reports and case series have shown encouraging results. This study investigated SARS-CoV-2 antibodies epidemiological characteristics in donors, identify criteria donor selection.Recovered COVID-19 patients, aged 18-55 years, who had experienced no symptoms more than 2 weeks, were recruited. Donor such as presentations collected...