A5101930689- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Impact on Reproduction
- SARS-CoV-2 detection and testing
- Cancer Immunotherapy and Biomarkers
- Diabetes and associated disorders
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Long-Term Effects of COVID-19
- Chronic Kidney Disease and Diabetes
- Organ Donation and Transplantation
- Hernia repair and management
- Sodium Intake and Health
- Metamaterials and Metasurfaces Applications
- Chronic Disease Management Strategies
- Phytochemistry and Bioactive Compounds
- Ethics in Clinical Research
- Entrepreneurship Studies and Influences
- Renal Diseases and Glomerulopathies
- Thermal Regulation in Medicine
- Higher Education and Employability
- Hepatitis B Virus Studies
- Diabetes Treatment and Management
- Vocational and Entrepreneurial Education
- Nausea and vomiting management
Sichuan University
2025
West China Hospital of Sichuan University
2025
Nanjing Medical University
2025
Jiangsu Province Hospital
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
Shaoxing People's Hospital
2021-2024
Peking Union Medical College Hospital
2023
Hainan University
2021
Central South University
2021
Jinhua Academy of Agricultural Sciences
2021
<h3>Importance</h3> Convalescent plasma is a potential therapeutic option for patients with coronavirus disease 2019 (COVID-19), but further data from randomized clinical trials are needed. <h3>Objective</h3> To evaluate the efficacy and adverse effects of convalescent therapy COVID-19. <h3>Design, Setting, Participants</h3> Open-label, multicenter, trial performed in 7 medical centers Wuhan, China, February 14, 2020, to April 1, final follow-up 28, 2020. The included 103 participants...
The lack of effective treatments against the 2019 coronavirus disease (COVID-19) has led to exploratory use convalescent plasma for treating COVID-19. Case reports and case series have shown encouraging results. This study investigated SARS-CoV-2 antibodies epidemiological characteristics in donors, identify criteria donor selection.Recovered COVID-19 patients, aged 18-55 years, who had experienced no symptoms more than 2 weeks, were recruited. Donor such as presentations collected...
Abstract Background COVID-19 has caused a global pandemic and the death toll is increasing. However, there no definitive information regarding type of clinical specimens that best for SARS-CoV-2 detection, antibody levels in patients with different duration disease, relationship between level viral load. Methods Nasopharyngeal swabs, anal saliva, blood, urine were collected from course disease ranging 7 to 69 days. Viral load specimen types was measured using droplet digital PCR (ddPCR)....
Background Emerging evidence indicates that immune checkpoint inhibitor-induced diabetes mellitus (ICI-DM) might be more common than initially reported, and different clinical pictures associated with ICI-DM were described. Objective The aim of our study was to identify the characteristics possible predictive factors ICI-DM. Methods We conducted a retrospective review patients who received inhibitors (ICI) at West China Hospital, Sichuan University until June 2023. Patients reviewed death or...
Objective: To investigate the effect of injectable adipose tissue stem cell-derived exosome-encapsulated hydrogel on tendon healing in rats and to evaluate temporal spatial expressions periphery neuropeptides at site. Methods: generate hydrogel, methacryloylchloride solution (GelMA) photoinitiator were mixed first, then exosome was added oscillated together. Followed with exposing ultraviolet light a wave length 405 nm for 30 seconds form an hydrogel. The Sprague Dawley (SD) performed full...
Background: Cystatins, encoded by the CST gene family, are a superfamily of cysteine protease inhibitors involved in wide array biological functions, including immune modulation and antimicrobial defense. Cystatin proteins implicated tumor progression through multiple mechanisms. However, their roles bladder cancer remain poorly understood. Objective: This study examined expression profiles cystatin family genes analyzed correlation with clinicopathological parameters using Cancer Genome...
Abstract Background To investigate the readiness for hospital discharge of patients discharged with tubes from department hepatobiliary surgery and to explore influencing factors. Methods A cross-sectional survey was conducted 161 who were Shaoxing Second Hospital by using modified Chinese version Readiness Discharge Scale (RHDS) Quality Teaching (QDTS). General data patients, such as gender, age, BMI (body mass index), educational level, collected. Results According statistical results,...
A novel coronavirus has caused an international outbreak. Currently, there are no specific therapeutic agents for infections. Convalescent plasma (CP) therapy is a potentially effective treatment option.Patients who had recovered from COVID-19 and been discharged the hospital more than 2 weeks were recruited. convalescent (CCP)-specific donor screening selection performed based on following criteria: 1) aged 18-55 years; 2) eligible blood donation; 3) diagnosed with COVID-19; 4) two...
Coronavirus disease 2019 (COVID-19) continues to impact global public health. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become less virulent as it mutates, prompting China ease restrictions at the end of 2022. With complete reopening, a surge in COVID-19 cases ensued. Therefore, we conducted study explore correlation between plasma antibody levels and baseline conditions or clinical outcomes critical patients. We collected basic information 79 included...
Abstract Background Dengue virus (DENV) infection is increasingly common in southern China and can be transmitted through blood transfusion but not currently part of donor screening throughout the region. We assessed DENV prevalence among donors at Xishuangbanna Blood Center, Yunnan, to support development strategies. Methods samples were collected randomly between June 2019 August 2019. These screened for anti-DENV IgG IgM using enzyme-linked immunosorbent assay (ELISA). Then, all reactive...
Since early 2020, convalescent plasma has been widely used for treating coronavirus disease 2019 (COVID-19). There is limited information regarding donor tolerability of donation. In this study, we evaluated the short-term donation.A prospective study 309 donation related adverse events were conducted at Wuhan Blood Center China, from February 12 to April 1, 2020. Additionally, up 28-day post-donation follow-ups performed on donors.Sixteen (5.2%) reported in donations. All these mild...
To analyze the clinical value of high b-value 3.0 T biparametric magnetic resonance with Simplified Prostate Image Reporting and Data System (S-PI-RADS) in biopsy-naïve men.A retrospective analysis data 224 patients who underwent prostate biopsy (cognitive fusion targeted combined systematic biopsy) after a examination at Haikou Hospital from July 2018 to 2020 was performed. Two radiologists performed multi-parameter imaging (mp-MRI) report system version 2 (PI-RADS v2) (bp-MRI) simplified...
Abstract Background Pathogen reduction technology has become an accepted method for limiting transfusion‐transmitted infections (TTIs). Riboflavin and ultraviolet light (RUV) treatment of platelets (PLTs) is optional means pathogen inactivation owing to its safety, effectiveness, ease use. However, the literature on effects (UV) spectra doses still contradictory. Methods We tested effectiveness killing Escherichia coli following RUV exposure with one broad‐spectrum two narrow‐spectrum...
Objectives: The aim of the present study was to evaluate modified glomerular filtration rate (GFR) prediction formulae in an elderly Chinese population with chronic kidney disease (CKD). Methods: A total 378 patients CKD were enrolled. GFR estimated six formulae. performances GFRs compared those standard measured by technetium-99m diethylenetraminepentaacetic acid. Results: Biases similar for formula 1, Asian formula, and 2 (median difference, 2.22 mL/min/1.73 m 2.59 1 respectively, versus...
This study examines the therapeutic potential of monotropein (Mon) in a rat model acute pulmonary embolism (APE), aiming to elucidate its mechanistic role and provide new insights for APE treatment. Thirty Sprague Dawley (SD) rats were randomly assigned five groups (n = 6 per group): sham, Mon (40 mg/kg), APE, + 20 mg/kg Mon, 40 Mon. was induced via autologous thrombus infusion all except sham Mon-only groups. We assessed blood gas parameters, lung wet/dry weight (W/D) ratio, oxidative...
The external cloak is a special device that can make an object outside the cloaking shell invisible. In this paper, inverse method based on numerical solution of Laplace's equation applied to design arbitrary shape cloak, without any knowledge coordinate transformation. performance verified by full-wave simulation. extended three dimensional case, which greatly enhances applicability cloak.
Clinical trials of convalescent plasma therapy for coronavirus disease 2019 (COVID-19) are extensive, but the relationship between antibody titers, infused volume and virus clearance in patients remains unknown. This study proposed a possible estimating equation clinical use high titer plasma.A total 38 were recruited Guanggu District Maternal Child Health Hospital Hubei Province from March 1 to 30, 2020. COVID-19 was collected high-titer (≥1:640) anti-S-RBD units used. The SARS-CoV-2...
Objective To investigate the clearing effects and safety of various blood purification modes on β2-microglulin (β2-MG)in acute kidney injury(acute injury, AKI)children. Methods We collected 38 injury children including 98 cases by treatment in department nephrology immunology PICU Children's Hospital Guiyang from March 2011 to 2013, which males 20 females 18, aged 5 months 14.Sixty-six underwent continuous renal replacement therapy(CRRT)including veno-venous hemofiltration(CVVH)...
Objective To investigate the role of Th17/CD4+ CD25+ regulatory T lymphocytes(Treg) and its effector in children with primary glomerular diseases. Methods Peripheral blood: 30 patients diseases from December 2013 to 2014 Department Nephrology at Guiyang Children's Hospital were enrolled as experimental group, 20 male, 10 female; age: 1.6-14.0 years old [(8.2±3.8) old]. Meanwhile, healthy age-matched after physical examination collected health control 8 male 2 female, mean age...
Abstract Objective: To evaluate the clinical significance of preoperative plasma lipid profile, including triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL-C), and high-density (HDL-C), in patients with lung adenocarcinoma (LUAD) status post complete resection. Methods: Clinical data, profile levels, were retrospectively collected reviewed 304 LUAD who underwent radical resection between 2016–2017. The overall survival (OS) disease-free (DFS) assessed by Kaplan–Meier...
Abstract Coronavirus disease 2019 (COVID-19) continues to impact global public health. The sever acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become less virulent as it mutates, so China relaxed its control the at end of 2022. With full opening, many COVID-19 patients have begun appear. Therefore, we conducted a study explore correlation between plasma antibody level and baseline conditions or clinical outcomes in severe critical patients. We collected basic information 79...