A5065406042- Autoimmune and Inflammatory Disorders Research
- Immune Cell Function and Interaction
- Parvovirus B19 Infection Studies
- Adolescent and Pediatric Healthcare
- Lymphoma Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Childhood Cancer Survivors' Quality of Life
- RNA modifications and cancer
- Chronic Lymphocytic Leukemia Research
- Electrolyte and hormonal disorders
- Cancer therapeutics and mechanisms
- Potato Plant Research
- Vascular Malformations and Hemangiomas
- Cytomegalovirus and herpesvirus research
- Oral health in cancer treatment
- Cutaneous lymphoproliferative disorders research
- Multiple Myeloma Research and Treatments
- Cancer-related gene regulation
- Muscle and Compartmental Disorders
- Kawasaki Disease and Coronary Complications
- Tendon Structure and Treatment
- Bone and Joint Diseases
- Circular RNAs in diseases
- T-cell and Retrovirus Studies
- Mobile and Web Applications
Nanjing Medical University
2015-2025
Jiangsu Province Hospital
2015-2025
Objective: To investigate the effect of injectable adipose tissue stem cell-derived exosome-encapsulated hydrogel on tendon healing in rats and to evaluate temporal spatial expressions periphery neuropeptides at site. Methods: generate hydrogel, methacryloylchloride solution (GelMA) photoinitiator were mixed first, then exosome was added oscillated together. Followed with exposing ultraviolet light a wave length 405 nm for 30 seconds form an hydrogel. The Sprague Dawley (SD) performed full...
Secondary hemophagocytic lymphohistiocytosis (sHLH) is a rare life-threatening systemic disease. This study aimed to assess the prognostic value of pretreatment albumin-bilirubin (ALBI). We retrospectively analyzed 168 non-Hodgkin lymphoma-associated secondary (NHL-sHLH) patients with hepatic injuries. Multivariable logistic/Cox models and restricted cubic spline were conducted evaluate relationships between ALBI score short- long-term survival. Among adult NHL-sHLH patients, 82 (48.8%) died...
Multidrug resistance 1 (MDR1) gene encodes P-glycoprotein (P-gp), which acts as an efflux pump and provides cell protection against various substances, its single-nucleotide polymorphisms (SNPs) are associated with the development of malignant hematologic diseases. The present study aimed at investigating whether MDR1 SNPs haplotype variants were correlated susceptibility to multiple myeloma (MM). A total 115 MM patients 153 healthy controls from Jiangsu Han population enrolled genotyped by...
Abstract Background In adult patients with secondary hemophagocytic lymphohistiocytosis (sHLH), no valid immune biomarker has been available for predicting the prognosis of untreated sHLH patients. Methods Circulating plasma levels fibrinogen (FIB) were measured at diagnosis in 293 cases sHLH. We categorized FIB into tertiles. Multivariable Cox proportional hazards models used to evaluate relationship between and survival. Restricted cubic spline two-piecewise address nonlinear association...
Purpose. Secondary hemophagocytic lymphohistiocytosis (sHLH) accompanied by liver involvement, characterized hepatomegaly and increased enzymes, is usually associated with elevated mortality. However, the magnitude of these associations remains unknown. Our objective was to assess aspartate transaminase/alanine transaminase (AST/ALT, De Ritis) ratio overall survival among adult patients sHLH. Methods. A retrospective analysis performed on 289 aged 18–86 years complete serum data at diagnosis...
MDR1 (multidrug resistance 1) encodes an adenosine triphosphate (ATP)-dependent efflux transporter that plays a fundamental role in transportation of harmful compounds outside cells to maintain optimal health. The present study was aimed investigate whether the gene single nucleotide polymorphisms (SNPs) were associated with prognosis diffuse large B cell lymphoma (DLBCL). Three common SNPs, including C1236T, G2677T/A, and C3435T focused on, total 150 DLBCL patients from Jiangsu Han...
This study aimed to examine the association between low T3 syndrome and overall survival (OS) in patients with secondary hemophagocytic lymphohistiocytosis (sHLH). The consisted of 111 consecutive hospitalized due newly diagnosed sHLH detailed thyroid hormone profiles on admission. Low was found 75.7% studied population. After a median follow-up 83 (interquartile range 25–365) days, there were 60 (71.4%) cumulative deaths group 13 (48.1%) euthyroid group. Survival analysis showed lower...
Non-Hodgkin lymphoma associated hemophagocytic lymphohistiocytosis (NHL-HLH) in adult secondary HLH is a common and universally highly lethal critical disorder. Hyponatraemia the most electrolyte disorder illness setting acts as negative prognostic factor. The aim of our study was to evaluate role hyponatraemia among patients with NHL-HLH. results showed that 81 (52.9%) had hyponatraemia. After median follow up 47 (range 14–180) days, there were 72 (88.9%) cumulative deaths group while 50...
Background.Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disease caused by immune hyperactivation.The overall survival (OS) of adults with secondary HLH remains suboptimal and new treatment strategies are needed.Objectives.This study aimed to compare the efficacy different regimens in analyze prognostic factors affecting patient survival. Materials methods.The clinical data 245 admitted our hospital from January 2016 October 2021 were analyzed retrospectively.The patients...
To investigate the effect of pre-treatment plasma Epstein-Barr virus (EBV) DNA copy number on clinical features and prognosis patients with adult secondary hemophagocytic lymphohistiocytosis(sHLH).
The 56th American Society of Hematology(ASH)annual meeting has reported 171 abstracts about hematopoietic stem cell transplantation(HSCT)for treating lymphoma, including 102 autologous HSCT(auto-HSCT)and 69 allogeneic HSCT(allo-HSCT), which mainly covered clinical effects HSCT on patients with relapse/refractory Hodgkin lymphoma and high risk, aggressive non-Hodgkin as well the impact factors such best time for transplantation, improvement conditioning regimen, applying target chemotherapy...
Abstract Purpose We aimed to examine the association between baseline platelet count (PLT) and prognosis of adult secondary hemophagocytic lymphohistiocytosis (sHLH). Material methods Data from 292 patients with pretreatment counts were retrospectively analysed January 2016 December 2020. categorized into quartiles. Multivariable Cox proportional hazards models restricted cubic splines (RCS) used evaluate relationship mortality. Results During a median follow-up 53 (interquartile ranges,...
Abstract Adult secondary hemophagocytic lymphohistiocytosis (sHLHa) is a condition of immune dysregulation and hyperinflammation that commonly associated with hepatic dysfunction. However, to date, no studies have systematically described liver test abnormalities in patients sHLHa. The contribution function tests (LFTs) the mortality sHLHa remains unclear. In this retrospective study, clinical records LFTs were obtained from 269 at admission. Multivariable logistic models restricted cubic...
Secondary hemophagocytic lymphohistiocytosis (sHLH) is a syndrome characterized by an excessive systemic inflammatory response, manifested multiple organ dysfunction, lacking reliable immune biomarkers for predicting their status and prognosis. Soluble fms-like tyrosine kinase 1 (sFlt-1) associated with various inflammation-related diseases, including sepsis severe failure.This study retrospectively included 32 adult sHLH patients diagnosed from January 2020 to December 2021. The expression...