A5100419122- Autoimmune and Inflammatory Disorders Research
- Parvovirus B19 Infection Studies
- Immunodeficiency and Autoimmune Disorders
- Chronic Lymphocytic Leukemia Research
- Gestational Trophoblastic Disease Studies
- Asthma and respiratory diseases
- Epilepsy research and treatment
- Cerebrovascular and Carotid Artery Diseases
- Acute Myeloid Leukemia Research
- Pituitary Gland Disorders and Treatments
- Traditional Chinese Medicine Studies
- Immune Cell Function and Interaction
- Reproductive Biology and Fertility
- Hematological disorders and diagnostics
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Complementary and Alternative Medicine Studies
- Renal Diseases and Glomerulopathies
- Ovarian function and disorders
- Muscle and Compartmental Disorders
- Ectopic Pregnancy Diagnosis and Management
- Biomedical Research and Pathophysiology
- Cancer-related molecular mechanisms research
- Reproductive System and Pregnancy
- Cancer, Stress, Anesthesia, and Immune Response
- Gout, Hyperuricemia, Uric Acid
Institute of Microbiology
2025
Anhui Medical University
2022-2024
Nanjing Medical University
2014-2024
Jiangsu Province Hospital
2014-2024
Second Hospital of Anhui Medical University
2024
Chinese Academy of Medical Sciences Dermatology Hospital
2024
Second Hospital of Shandong University
2024
Peking University Third Hospital
2023
Peking University
2023
Ministry of Education of the People's Republic of China
2023
Background: ZANU is a next-generation Bruton tyrosine kinase inhibitor (BTKi) designed to minimize off-target binding and limit associated side effects that approved in the US EU for CLL/SLL. Results from SEQUOIA study (NCT03336333), at median follow-up of 26.2 mo, demonstrated superior progression-free survival (PFS) by independent review vs BR pts with treatment-naïve (TN) CLL/SLL without (w/o) del(17p); del(17p) treated separate cohort had similar outcomes w/o del(17p). Aims: To report...
Abstract Uric acid is a powerful antioxidant. However, its elevated levels in association with cardiovascular diseases predispose individuals to cognitive impairment. acid’s effects on cognition may be related concentration and exposure period. We aimed explore the of long-term serum uric function hippocampus. Rats were randomly divided into four groups: NC, M1, M2 M3 groups. Hyperuricemia was established rats at week 6 maintained until 48 groups M3. The rats’ spatial learning memory...
In late 2023, the first human case caused by an H10N5 avian influenza virus (AIV) was diagnosed in China. H10Ny AIVs have been identified various poultry and wild birds Eurasia, Americas, Oceania. We analyzed clinical data of AIV-infected patient, isolated virus, evaluated receptor-binding properties together with H10N8 H10N3 humans poultry. The genomic human-infecting strain (n = 48, including 16 strains 2 H10N8) from live markets China, during 2019-2021, were sequenced. inferred genetic...
Monocyte chemoattractant protein-1 (MCP-1) and its receptor CCR2 stimulate inflammation response by activating recruiting monocytes/macrophages. MCP-1 polymorphisms were reported to be associated with various diseases. To explore the relationship between IgA nephropathy (IgAN), we conducted this case-control study enrolling 351 IgAN patients 310 health controls. Odds ratios (ORs) 95% confidence intervals (CIs) calculated evaluate potential associations of susceptibility clinical parameters...
Abstract Cancer‐initiating cells ( CIC s) are a limited number of that essential for maintenance, recurrence, and metastasis tumors. Aldehyde dehydrogenase 1 ALDH 1) has been recognized as marker s. We previously reported 1‐high cases uterine endometrioid adenocarcinoma showed poor prognosis, high population was more tumorigenic, invasive, resistant to apoptosis than low population. Histamine plays critical role in cancer cell proliferation, migration, invasion. Here, we examined the effect...
Immature PIT1-lineage pituitary neuroendocrine tumors (PitNETs)/adenomas (Immature tumors) are a rare and underrecognized subtype of PitNETs that exhibits distinct cytologic atypia features aggressive clinical potential. This study characterizes the clinical, radiological, histologic, immunohistochemical 15 immature identified from 1084 patients over 5 years. Our cohort 6 males 9 females had median age 37.00 years (range: 23 to 68 y). All presented with macrotumors an average size...
This study aimed to explore the association between serum non-high-density lipoprotein cholesterol (non-HDL-C) and cognitive dysfunction risk in patients with acute ischemic stroke (AIS). cross-sectional enrolled 583 AIS patients. Biochemical markers lipid profile were collected after admission. classified into high group (non-HDL-C ≥3.4 mM) normal <3.4 mM). Mini-Mental State Examination scale (MMSE), Montreal Cognitive Assessment (MoCA), Activities of Daily Living (ADL) scale,...
The aim of the present study was to establish a recurrent convulsion model during developmental stage using inhalation flurothyl, and observe relationship between changes in mitochondrial function hippocampal neurons neuronal apoptosis after convulsion. A total 36 Sprague-Dawley male rats were selected randomly divided into control (NS) group recurrent-seizure (RS) for 0, 1.5, 3, 12 24 h. After last seizure subdivided with 6 animals each group. Rats inhaled flurothyl repeatedly induce status...
Background. Lung transplantation has been performed worldwide and admitted as an effective treatment for patients with various end-stage lung diseases. However, limit reliable clinical indicators exist to identify at high risk allograft failure in transplant recipients. The recent advances the knowledge of immunological aspects pulmonary diseases, that innate macrophage activation, are induced by pathogen or pathogen-derived molecules widely accepted critical evidence among pathogenesis...
Cough variant asthma (CVA) is a chronic inflammatory airway disease characterized by hyper-responsiveness (AHR), of which cough the only symptom. The result contraction vocal cords, diaphragm, sternocleidomastoid muscle, and other respiratory related muscles caused AHR. Long-term coughing can lead to repetitive strain involved in head neck, ultimately contributing formation latent myofascial trigger points (MTrPs). In turn, MTrPs also irritate or compress nerves around them, triggering...
Background Polycystic ovary syndrome (PCOS) is a complex reproductive endocrine and metabolic disease affecting women of age. The low-grade chronic inflammation in PCOS considered to be associated with obesity dyslipidemia. We aim investigate the potential mediating role white blood cell (WBC) count, representative inflammatory marker, effect adiposity lipid metabolism indicators on IVF/ICSI outcomes women. Methods conducted retrospective cohort study 1,534 who underwent their first cycles...
Endothelial nitric oxide synthase (eNOS) is one of the most important enzymes for producting (NO), which regulate function many organs and cells. The single nucleotide polymorphisms (SNPs) eNOS were found to be associated with kidney diseases. However, it lack relevant studies evaluate associations between immunoglobulin A nephropathy (IgAN). This case-control study aimed relationship IgAN.We recruited 351 IgAN patients 310 age- sex-matched healthy controls from Northwest China. Sequenom...
We assessed the correlation between serum carbohydrate antigen 125 (CA125) and carotid intima-media thickness (cIMT) in patients with coronary artery disease (CAD).We collected 518 CAD from cardiovascular center our hospital, all cIMT values were measured CAD.The CA125 concentrations found to be increased early atherosclerosis compared without (20.1±7.72 vs. 17.7±6.41 U/mL, p<0.001). The higher CA-125 levels than those lower (1.16±0.32 0.98±0.29 mm, There was a positive (r=0.262, Moreover,...
To investigate the expression levels and clinical significance of serum high mobility group box 1 (HMGB-1) in patients with secondary hemophagocytic lymphohistiocytosis (sHLH).Serum HMGB-1 were determined by using enzyme linked immunosorbent assays (ELISA) 51 sHLH 15 healthy contrlols. Other laboratory data, including soluble interleukin-2 receptor (sCD25), white blood cells (WBC), hemoglobin (Hb), platelet (Plt), fibrinogen (FIB), lactate dehydrogenase (LDH), triglyceride (TG), alanine...
<title>Abstract</title> <bold>Objective: </bold>The purpose of this study was to explore the mediating role depression between fatigue and sleep quality in patients after renal transplantation. <bold>Methods:</bold> The general information questionnaire, Pittsburgh Sleep Quality Index (PSQI), Multidimensional Fatigue Inventory (MFI-20) Patient Health Questionnaire 9 (PHQ-9) were used evaluate 200 kidney transplant our department from May 2019 November 2020. <bold>Results:</bold> total PSQI...
Background: The aim of this study was to investigate the correlation between phospholipase A2 receptor (PLA2R) gene polymorphism and idiopathic membranous nephropathy (IMN) in Heilongjiang Chinese.