A5013948185- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Glycosylation and Glycoproteins Research
- Immune Response and Inflammation
- Immunodeficiency and Autoimmune Disorders
- Galectins and Cancer Biology
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Chronic Lymphocytic Leukemia Research
- IL-33, ST2, and ILC Pathways
- Cell Adhesion Molecules Research
- Systemic Lupus Erythematosus Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Reproductive System and Pregnancy
- Microscopic Colitis
- Lymphoma Diagnosis and Treatment
- Autoimmune and Inflammatory Disorders Research
- interferon and immune responses
- Cytomegalovirus and herpesvirus research
- Signaling Pathways in Disease
- Transgenic Plants and Applications
- Complement system in diseases
Beth Israel Deaconess Medical Center
2014-2024
Harvard University
2013-2023
Queen's University
2023
Harvard University Press
1985-2016
Beth Israel Deaconess Hospital
1992-2016
Hadassah Medical Center
2004-2013
Massachusetts General Hospital
1984-2012
University of Cincinnati Medical Center
2012
Cincinnati Children's Hospital Medical Center
2012
Brigham and Women's Hospital
1990-2006
The presence of natural killer (NK) cells contributes to early defense against murine cytomegalovirus (MCMV) infection. Although NK can mediate in vivo protection MCMV, the mechanism by which they do so has not been defined. studies presented here evaluate cytokine production activated during MCMV infection and role cell-produced cytokines antiviral defenses. Experiments with normal C57BL/6, T cell-deficient C57BL/6 nude, severe combined immunodeficient mice lacking B demonstrated that both...
The requirements for interleukin (IL)-12/signal transducer and activator of transcription (Stat)-4 signaling induction T cell-specific interferon (IFN)-gamma expression in the development helper cell (Th)1-type pathology were examined two different models experimental colitis. In each model, abnormal reconstitution compartment immunodeficient mice by adoptive transfer leads to a wasting syndrome inflammation colon, induced IFN-gamma tumor necrosis factor (TNF)-alpha-producing cells. We show...
The human CD1 locus encodes three nonpolymorphic MHC class I-like cell surface glycoproteins, CD1a-c, which are expressed primarily by immature thymocytes. A mAb and antipeptide antiserum were utilized to determine the tissue distribution of a fourth molecule, CD1d. Within lymphoid lineage, CD1d was on B cells but not Immunoperoxidase staining fresh frozen intestinal tissues demonstrated that majority epithelial cells, with exception at base some crypts, observed in cytoplasm along...
We describe a monoclonal antibody, WT-31, that reacted with all human T lymphocytes. Electrophoretic analysis of the material reacting WT-31 revealed it precipitated predominantly an 80-kD disulfide-linked heterodimer from cell surface-labeled leukemic line HPB-ALL. This was identical to one recently described reagent, T40/25, which recognizes clonotypic structure on The target antigen comodulated T3 after incubation cells excess anti-T3 indicating is associated T3. also found reagents, but...
A severe immunodeficiency involving a complete loss of T lymphocytes and natural killer cells was observed in independent lines transgenic mice containing > 30 copies the human CD3E gene (pL12). T-cell- (NK)- could also be generated by using fragment pL12 delta 1 (without exons 4A 5) coding for CD3-epsilon transmembrane region its 55-amino acid nonenzymatic cytoplasmic tail. The abnormally small thymus gland homozygous animals, which approximately 1% size wild-type thymus, contained only...
The lymphokine interleukin-2 (IL-2) is responsible for autocrine cell cycle progression and regulation of immune responses. Uncontrolled secretion IL-2 results in adverse reactions ranging from anergy, to aberrant T activation, autoimmunity. With the use fluorescent situ hybridization single-cell polymerase chain reaction cells with different alleles, expression mature thymocytes was found be tightly controlled by monoallelic expression. Because encoded at a nonimprinted autosomal locus,...
Cluster of differentiation 1 (CD1) in humans is a family major histocompatibility complex (MHC) class I-like molecules expressed on the surface immature thymocytes, Langerhans cells, and subpopulation B cells. The only function identified for human CD1 as ligand recognized by T lymphocytes. In order to study distribution these mouse, murine complementary DNA was mouse fibroblasts used produce monoclonal antibodies. These antibodies revealed prominent expression gastrointestinal tract...
Mo1, a phagocyte surface glycoprotein heterodimer, is involved in number of adhesion functions such as binding and ingestion serum-opsonized particles, zymosan-induced degranulation, superoxide generation. Deficiency this antigen humans has been associated with increased susceptibility to recurrent bacterial infections. The beta subunit Mo1 shared by another named LFA-1, which lymphocyte proliferation, cytolytic T cell, natural killing activities. Two unrelated patients deficiency were found...