A5076675601- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Pharmaceutical studies and practices
- Health Systems, Economic Evaluations, Quality of Life
- Nutritional Studies and Diet
- Pharmaceutical Economics and Policy
- Gastrointestinal motility and disorders
- Herpesvirus Infections and Treatments
- Biotechnology and Related Fields
- Reproductive System and Pregnancy
- Cytomegalovirus and herpesvirus research
- Digestive system and related health
- Pharmacogenetics and Drug Metabolism
- Gut microbiota and health
- Immunodeficiency and Autoimmune Disorders
- Gastroesophageal reflux and treatments
- Chemical Reactions and Isotopes
- Cervical Cancer and HPV Research
- Glutathione Transferases and Polymorphisms
- IL-33, ST2, and ILC Pathways
- CAR-T cell therapy research
Weifang People's Hospital
2025
Tianjin Medical University General Hospital
2024
Harvard University
1994-2013
Brigham and Women's Hospital
2013
Beth Israel Deaconess Medical Center
1998-1999
Brown University
1995
Beth Israel Deaconess Hospital
1994
The presence of natural killer (NK) cells contributes to early defense against murine cytomegalovirus (MCMV) infection. Although NK can mediate in vivo protection MCMV, the mechanism by which they do so has not been defined. studies presented here evaluate cytokine production activated during MCMV infection and role cell-produced cytokines antiviral defenses. Experiments with normal C57BL/6, T cell-deficient C57BL/6 nude, severe combined immunodeficient mice lacking B demonstrated that both...
A severe immunodeficiency involving a complete loss of T lymphocytes and natural killer cells was observed in independent lines transgenic mice containing > 30 copies the human CD3E gene (pL12). T-cell- (NK)- could also be generated by using fragment pL12 delta 1 (without exons 4A 5) coding for CD3-epsilon transmembrane region its 55-amino acid nonenzymatic cytoplasmic tail. The abnormally small thymus gland homozygous animals, which approximately 1% size wild-type thymus, contained only...
Abstract The association of dietary inflammatory index (DII) with constipation has not been well studied in general population. Therefore, the aim this cross‐sectional study was to investigate whether DII is associated a large representative sample US Data were obtained from 2005–2010 National Health and Nutrition Examination Survey (NHANES). A total 12,308 participants aged ≥20 years included analysis. calculated based on single 24‐h recall, defined as having fewer than three bowel...
Over-expression of human or mouse CD3-epsilon transgenes profoundly disturbs T lymphocyte and natural killer (NK) cell development. One these transgenic strains, termed tgepsilon26, displays a very early block in NK We showed previously that the absence thymocyte progenitors results an abnormal thymic microenvironment. Due to this defect, development could not be restored by bone marrow (BM) transplantation adult tgepsilon26 mice but fetal mice. Here we examine effect environment on...
The TCR-associated CD3 complex consists of four subunits, i.e. gamma, delta, epsilon and zeta, which are expressed very early in T cell development prior to the expression TCR pre-TCR alpha chain. It is unclear whether each protein independent of, or influenced by, other subunits. To study regulates gamma delta genes, we generated a strain epsilon-deficient mice termed epsilon(delta P/delta P) (epsilon(delta P)), promoter CD3E was disrupted, subsequently reconstituted these with transgene....