A5025312981- Immune Cell Function and Interaction
- Viral Infections and Immunology Research
- Animal Disease Management and Epidemiology
- Immune Response and Inflammation
- RNA regulation and disease
- Immunotherapy and Immune Responses
- Ideological and Political Education
- IL-33, ST2, and ILC Pathways
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- vaccines and immunoinformatics approaches
- Cholinesterase and Neurodegenerative Diseases
- Immune cells in cancer
- CAR-T cell therapy research
- Microbial Natural Products and Biosynthesis
- Cardiac pacing and defibrillation studies
- Educational Technology and Assessment
- Immunodeficiency and Autoimmune Disorders
- Herpesvirus Infections and Treatments
- Cardiovascular Function and Risk Factors
- interferon and immune responses
- Problem and Project Based Learning
- T-cell and B-cell Immunology
- Influenza Virus Research Studies
- Fungal Biology and Applications
Army Medical University
2018-2023
Xinqiao Hospital
2018-2023
Institut Pasteur of Shanghai
2013-2019
Guiyang Medical University
2017
Chinese Academy of Sciences
2014-2015
Shanghai Institutes for Biological Sciences
2013-2015
Enterovirus 71 (EV71) is the most virulent pathogen among enteroviruses that cause hand, foot and mouth disease in children but rarely adults. The mechanisms determine age-dependent susceptibility remain largely unclear. Here, we found paucity of invariant natural killer T (iNKT) cells together with immaturity immune system was related to neonatal mice EV71 infection. iNKT were crucial antiviral effector protect young from infection before their adaptive systems fully mature. led activation...
Coxsackievirus A16 (CVA16) is one of the major etiological agents hand, foot, and mouth disease (HFMD) in children. The host defense mechanisms against CVA16 infection remain almost entirely unknown. Unlike previous observations with enterovirus 71 (EV71) infection, here we show that gamma interferon (IFN-γ) or invariant NK T cell deficiency does not affect development survival CVA16-infected mice. In contrast, type I receptor resulted more severe mice, mice had a lower rate than wild-type...
Abstract Excessive or uncontrolled release of proinflammatory cytokines caused by severe viral infections often results in host tissue injury even death. Phospholipase C (PLC)s degrade phosphatidylinositol-4, 5-bisphosphate (PI(4,5)P2) lipids and regulate multiple cellular events. Here, we report that PLCβ2 inhibits the virus-induced expression pro-inflammatory interacting with inhibiting transforming growth factor-β-activated kinase 1 (TAK1) activation. Mechanistically, PI(4,5)P2 directly...
Abstract Background The effects of novel-dose Sacubitril/Valsartan (S/V) in patients with heart failure (HF) the real world have not been adequately studied. We examined risk for all-cause re-admission HF taking S/V and possible mediator role left ventricular reverse remodeling (LVRR). Methods Results There were 464 recruited from December 2017 to September 2021 our hospital a median follow-up 660 days (range, 17-1494). Model 1 2 developed based on results univariable competing analysis,...
Objective To study the antimicrobial activity of chemically synthesized Musca domestica cecropin-4 (mdCec4) against Acinetobacter baumannii. Methods Minimum inhibitory concentration (MIC) and minimum bactericidal (MBC) mdCec4 baumannii were detected by microdilution method. Dynamic time-kill curve was monitored microplate reader. Effects different influencing factors, such as NaCl, trypsin pH value, on assessed. The ultrastructure exposed to MIC observed under scanning electron...
Objective To determine the effects and advantage of PBL teaching method combined with LBL over method. Methods The interns from Department Clinical Laboratory were selected as subjects. Fifty assigned randomly into two groups, 25 in PBL+LBL group, group. After designed teaching, exam scores satisfaction question-naire was evaluated. All data analyzed SPSS 22.0. Counting Chi-square, Fisher test because smaller number. Results In test, group significantly higher than that...
Abstract Tumor antigens are mainly low-avidity to T cells and unable elicit effective anti-tumor immunity. Little knowledge on how cell response in vivo further hinders designing strategies improve immune response. Using a unique mouse tumor model, we found that neither native antigen nor majority of altered peptide ligands (APLs) derived from but only intermediate avidity APL was able robust cross-reactive tumor-specific CD8 Central tolerance shifted repertoire allow host respond low APLs...
Abstract Transgenic expression of I-E molecules prevents diabetes in NOD mice. So far, the precise role these non-classical MHC II remains elusive. Here, we showed that transgenic k alpha 16 molecule mice selectively reduced Th17 cells thymus and pancreatic draining lymph nodes. The reduction was associated with both attenuated IL-6 production decreased activation macrophages. Mechanistically, diminished intracellular classical led to impaired TLR4-mediated signaling. In contrast molecule,...