A5102019364- Animal Genetics and Reproduction
- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Tuberculosis Research and Epidemiology
- Cancer-related gene regulation
- Cancer Mechanisms and Therapy
- Endoplasmic Reticulum Stress and Disease
- Chromatin Remodeling and Cancer
- Advanced Chemical Sensor Technologies
- Bacterial Genetics and Biotechnology
- Epigenetics and DNA Methylation
- Pneumocystis jirovecii pneumonia detection and treatment
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cellular transport and secretion
- RNA and protein synthesis mechanisms
- Chronic Lymphocytic Leukemia Research
- Spectroscopy and Chemometric Analyses
- Heat shock proteins research
- Identification and Quantification in Food
- Immune Cell Function and Interaction
- Recommender Systems and Techniques
- Amino Acid Enzymes and Metabolism
- Text and Document Classification Technologies
Tongji University
2015-2025
Shanghai Pulmonary Hospital
2015-2025
First Bethune Hospital of Jilin University
2024
Nanjing Medical University
2020-2024
Jiangsu Cancer Hospital
2023-2024
Chinese Academy of Sciences
2015-2024
Ningbo University
2024
Fujian Institute of Research on the Structure of Matter
2015-2024
Sun Yat-sen University
2023
Huazhong Agricultural University
2022
Adaptation to hypoxia is a major challenge for the survival of Mycobacterium tuberculosis (Mtb) in vivo. Interferon (IFN)-γ-producing CD8
Immune microenvironment could affect the biological progress in prostate cancer (PCa) through N6 methyl adenosine (m6A) methylation. The purpose of this study was to investigate crosstalk between m6A methylation and immune explore potential biomarkers improve immunotherapeutic response. Firstly, according 11 differentially expressed genes normal tumor samples, PCa patients were divided into subtype 1 (IMS1) IMS2 based on gene profiles extracted from Cancer Genome Atlas (TCGA) database....
Abstract Internal N 6 -methyladenosine (m A) modifications are among the most abundant of messenger RNA, playing a critical role in diverse biological and pathological processes. However, functional regulatory mechanism m A immune response to Mycobacterium tuberculosis infection remains unknown. Here, we report that methyltransferase-like 14 (METTL14)-dependent methylation NAPDH oxidase 2 ( Nox2 ) mRNA was crucial for host defense against M. -secreted antigen EsxB (Rv3874) inhibited...
Currently, the photostability of photosensitizer curcumin is main bottleneck limiting their application, reducing bioavailability curcumin. Studying effect different light sources on photostabilities and loading it onto polydopamine nanocarriers with better biocompatibility will help improve its utilization efficiency. In this study, we investigated a polydopamine-based nanoparticle (polydopamine-curcumin composite nanoparticles, PDA-Cur NPs) loaded through in vitro vivo experiments to...
Abstract Antimicrobial peptides (AMPs), ancient scavengers of bacteria, are very poorly induced in macrophages infected by Mycobacterium tuberculosis ( M. ), but the underlying mechanism remains unknown. Here, we report that L-alanine interacts with PRSS1 and unfreezes inhibitory effect on activation NF-κB pathway to induce expression AMPs, mycobacterial alanine dehydrogenase (Ald) Rv2780 hydrolyzes reduces level macrophages, thereby suppressing AMPs facilitate survival mycobacteria....
Non-tuberculous mycobacterial pulmonary disease (NTM-PD) is a chronic progressive lung that increasing in incidence. Host genetic factors are associated with NTM-PD susceptibility. However, the heritability of not well understood. Here, we perform two-stage genome-wide association study (GWAS) and discover susceptibility locus at 16p21 NTM-PD, especially Mycobacterium avium complex (MAC) disease. As lead variant, rs194800 C allele augments protein kinase beta (PRKCB) gene expression...
GM130 and GRASP65 are Golgi peripheral membrane proteins that play a key role in stacking vesicle tethering. However, the molecular details of their interaction structural as functional unit remain unclear. Here, we present crystal structure PDZ domains complex with C-terminal peptide at 1.96-Å resolution. In contrast to previous findings proposing interacts PDZ2 domain only, our indicates binds two distinct sites concurrently both PDZ1 participate this interaction. Mutagenesis experiments...
Mycobacterial arabinogalactan (AG) is an essential cell wall component of mycobacteria and a frequent structural bio-synthetical target for anti-tuberculosis (TB) drug development. Here, we report that mycobacterial AG recognized by galectin-9 exacerbates infection. Administration AG-specific aptamers inhibits cellular infiltration caused Mycobacterium tuberculosis (Mtb) or bovis BCG, moderately increases survival Mtb-infected mice marinum-infected zebrafish. interacts with carbohydrate...
Alicyclobacillus spp. are heat-resistant, acid-tolerant spore-forming bacteria that could survive in commercial pasteurized fruit juice and cause spoilage along with the production of medical, phenolic, or antiseptic off-flavor, without visible sediment. As poses a great challenge to industry, aim present paper has been twofold. Firstly, explore various identification, detection, control approaches have applied order prevent possible contamination, thus summarizing characteristics spawned by...
Tuberculosis, caused by Mycobacterium tuberculosis infection, remains a global threat to human health, but knowledge of the molecular mechanisms underlying pathogenesis is still limited. Although Notch4, member Notch receptor family, involved in initiation mammary tumors, its function M. infection unclear. In this study, we found that Notch4-deficient mice were more resistant with much lower bacterial burden and fewer pathological changes lungs. Notch4 inhibited tuberculosis-induced...
Producing large amounts of soluble proteins from bacteria remains a challenge, despite the help current various solubilizing fusion tags. Thus, developing novel tags is necessary. Antifreeze protein (AFP) has excellent solubility and hydrophilicity, but there are no reports on its use as tag. Additionally, precedent for using retro-proteins (reverse sequence) Therefore, we selected antifreeze AXX obtained retro-protein XXA by synthesizing gene development new tag.XXA exhibits better...
Typhae Pollen (TP) and Trogopterus Feces (TF) are well-known traditional medicine in china which widely used for thousands of years as drug pair called Shixiao San treatment blood stasis syndrome, specially shown great efficacy gynecological disease. Typhaneoside, vanillic acid p-coumaric the main bioactive components Pollen. This study was carried out comparing pharmacokinetic profile these three major rats after oral administration Pollen-Trogopterus (TP-TF) before compatibility. A...
BACKGROUND:Chemotherapy is widely used in gastric cancer treatment, but multidrug resistance remains a leading cause of chemotherapy failure. Trop2 highly expressed tumor tissues and greatly influences progression. However, little known about the relationship between drug cancer. MATERIAL AND METHODS:In present study, was knocked down BGC823 cells overexpressed HGC27. CCK-8 assay performed to explore expression cell proliferation treated with anticancer drugs. Flow cytometry assess apoptosis...
Abstract Background Birds exhibit a unique asymmetry in terms of gonad development. The female left generates functional ovary, whereas the right regresses. In males, both and gonads would develop into testes. How is this left/right established only females but not males remains unknown. epigenetic regulation gonadal developmental genes may contribute to sex disparity. modification histone tails such as H3K27ac tightly coupled chromatin activation gene expression. To explore whether marked...
Deeper understanding of the crosstalk between host cells and Mycobacterium tuberculosis (Mtb) provides crucial guidelines for rational design novel intervention strategies against (TB). Mycobacteria possess a unique complex cell wall with arabinogalactan (AG) as critical component. AG has been identified virulence factor Mtb which is recognized by galectin-9. Here, we demonstrate that galectin-9 directly inhibited mycobacterial growth through AG-binding property carbohydrate-recognition...
Lipid metabolic disorder occurs when ApoE gene is deficient. However, the role of Docosahexaenoic acid (DHA) in relieving hepatic lipid apolipoprotein E-deficient (ApoE -/-) mice remains unknown. We fed 3-month-old C57BL/6J wild-type (C57 wt) and -/- respectively with normal or DHA fortified diet for 5 months. found deficiency caused deposition increased levels plasma liver. Hepatic expression SRB1, CD36 FABP5 mice, protein HMGCR, LRP1 C57 wt after intervention. In DHA-fed LXRα/β PPARα...