A5103111487- interferon and immune responses
- Cancer-related molecular mechanisms research
- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- Chronic Lymphocytic Leukemia Research
- Cancer Mechanisms and Therapy
- Immune cells in cancer
- RNA Research and Splicing
- Aerodynamics and Fluid Dynamics Research
- Monoclonal and Polyclonal Antibodies Research
- RNA modifications and cancer
- HER2/EGFR in Cancer Research
- Enzyme Production and Characterization
- MicroRNA in disease regulation
- Viral Infections and Immunology Research
- PARP inhibition in cancer therapy
- Polysaccharides and Plant Cell Walls
- Advanced Glycation End Products research
- Diabetes and associated disorders
- Immune Cell Function and Interaction
- Liver Disease and Transplantation
- Mechanisms of cancer metastasis
- Protein Kinase Regulation and GTPase Signaling
- Nitric Oxide and Endothelin Effects
- Inflammasome and immune disorders
Tongji University
2021-2025
Shanghai Pulmonary Hospital
2021-2025
China Automotive Technology and Research Center
2020-2022
Zhejiang University
2014-2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2021
Second Military Medical University
2019-2020
Beijing University of Technology
2017
Beijing Water Science and Technology Institute
2017
Long noncoding RNAs (lncRNAs) play important roles in diverse biological processes; however, few have been identified that regulate immune cell differentiation and function. Here, we lnc-DC, which was exclusively expressed human conventional dendritic cells (DCs). Knockdown of lnc-DC impaired DC from monocytes vitro mouse bone marrow vivo reduced capacity DCs to stimulate T activation. mediated these effects by activating the transcription factor STAT3 (signal transducer activator 3). bound...
Host RNA helps promote viral replication Viruses exploit host metabolic networks for survival. Wang et al. identified a long noncoding (lncRNA) that enhances of multiple viruses in both mouse and human cells (see the Perspective by Kotzin al ). The expression this cytoplasmic lncRNA was induced independent type I interferon. directly bound to stimulated enzyme glutamic-oxaloacetic transaminase. This strategy may have relevance clinical diseases involving dysfunction infection. Science ,...
Abstract Immunometabolism is critical in the regulation of immunity and inflammation; however, mechanism preventing aberrant activation-induced immunopathology remains largely unclear. Here, we report that glyoxalase II (GLO2) glycolysis branching pathway specifically downregulated by NF-κB signaling during innate immune activation via tristetraprolin (TTP)-mediated mRNA decay. As a result, its substrate S -D-lactoylglutathione (SLG) accumulates cytosol directly induces d -lactyllysine...
The classical activation of macrophages, one major innate effector cells, requires IFN-γ pretreatment (priming) and subsequent TLR stimuli (triggering). priming effect can promote macrophages to secrete higher level proinflammatory cytokines but lower the anti-inflammatory cytokines, enhancing microbicidal tumoricidal activity macrophages. However, underlying molecular mechanisms for IFN-γ-priming on macrophage remain be fully understood. microRNAs (miRNAs) are now emerging as important...
Virus infection modulates both host immunity and genomic stability. Poly(ADP-ribose) polymerase 1 (PARP1) is a key nuclear sensor of DNA damage, which maintains integrity, the successful application PARP1 inhibitors for clinical anti-cancer therapy has lasted decades. However, precisely how gains access to cytoplasm regulates antiviral remains unknown. Here, we report that virus induces reactive nitrogen species (RNS)-dependent damage activates DNA-dependent protein kinase (DNA-PK)....
KN026 is a novel bispecific antibody that simultaneously binds to two distinct HER2 epitopes. This first-in-human phase I study evaluated the safety/tolerability, pharmacokinetics, preliminary efficacy, and potential predictive biomarker activity of administered as monotherapy patients with HER2-positive metastatic breast cancer (MBC).Female MBC who had progressed on prior anti therapies received intravenous at 5 mg/kg (once weekly), 10 20 every 2 weeks), or 30 3 weeks). Dose escalation was...
Immune memory is crucial for preventing hepatitis E virus (HEV) infection. Our study aims to investigate immunological characteristics and differences between vaccination natural HEV infection, taking into account that both can induce immune memory. We recruited 60 HEV-infected patients, 58 contingency HEV-vaccinated individuals 4 controls from an outbreak of in a nursing home June August 2023. Multicolor flow cytometry, ELISA, quantitative polymerase chain reaction (qPCR) were employed...
Interferon regulatory factor 3 (IRF3) is an essential transductor for initiation of many immune responses. Here, we show that lncRNA-ISIR directly binds IRF3 to promote its phosphorylation, dimerization, and nuclear translocation, along with enhanced target gene productions. In vivo deficiency results in reduced IFN production, uncontrolled viral replication, increased mortality. The human homolog, AK131315, also promotes activation. More important, AK131315 expression positively correlated...
Abstract Background Lung cancer is the second most common malignancy in world, and lung adenocarcinoma (LUAD) particular leading cause of death worldwide. Endothelin converting enzyme 1 (ECE1) a membrane‐bound metalloprotease involved endothelin‐1 (ET‐1) processing regulates vasoconstriction. However, very few studies have reported involvement ECE1 regulating tumor cell proliferation, mechanism remains poorly understood. Therefore, we aimed to determine role development. Methods The Cancer...
Deeper understanding of the crosstalk between host cells and Mycobacterium tuberculosis (Mtb) provides crucial guidelines for rational design novel intervention strategies against (TB). Mycobacteria possess a unique complex cell wall with arabinogalactan (AG) as critical component. AG has been identified virulence factor Mtb which is recognized by galectin-9. Here, we demonstrate that galectin-9 directly inhibited mycobacterial growth through AG-binding property carbohydrate-recognition...
Background Pattern recognition receptors (PRRs) family plays a vital role in the initial stage of innate immune response and subsequent activation adaptive immunity. Increasing evidences have indicated that several PRRs play critical roles progress inflammation tumorigenesis. However, comprehensive significance clinical prognosis different cancers is still elusive. Methods We analyzed expression 20 canonical tumor samples from 9502 patients 33 types. Next, we used profiles skin cutaneous...
Deeper understanding of the crosstalk between host cells and Mycobacterium tuberculosis (Mtb) provides crucial guidelines for rational design novel intervention strategies against (TB). Mycobacteria possess a unique complex cell wall with arabinogalactan (AG) as critical component. AG has been identified virulence factor Mtb which is recognized by galectin-9. Here we demonstrate that galectin-9 directly inhibited mycobacterial growth through AG-binding property carbohydrate-recognition...
Deeper understanding of the crosstalk between host cells and Mycobacterium tuberculosis (Mtb) provides crucial guidelines for rational design novel intervention strategies against (TB). Mycobacteria possess a unique complex cell wall with arabinogalactan (AG) as critical component. AG has been identified virulence factor Mtb which is recognized by galectin-9. Here we demonstrate that galectin-9 directly inhibited mycobacterial growth through AG-binding property carbohydrate-recognition...
Deeper understanding of the crosstalk between host cells and Mycobacterium tuberculosis (Mtb) provides crucial guidelines for rational design novel intervention strategies against (TB). Mycobacteria possess a unique complex cell wall with arabinogalactan (AG) as critical component. AG has been identified virulence factor Mtb which is recognized by galectin-9. Here, we demonstrate that galectin-9 directly inhibited mycobacterial growth through AG-binding property carbohydrate-recognition...
Immune checkpoint inhibitors, especially those targeting CD274/PD-L1yield powerful clinical therapeutic efficacy. Thoughmuch progress has been made in the development of antibody-basedCD274 drugs, chemical compounds applied for CD274degradation remain largely unavailable. Herein,baicalein, a monomer traditional Chinese medicine, isscreened and validated to target CD274 induces itsmacroautophagic/autophagic degradation. Moreover, we demonstrate thatCD274 directly interacts with MAP1LC3B...
Viruses evolve multiple strategies to evade host immune elimination. How lncRNAs are utilized by viruses for evasion remains further investigation. By screening virus infection-downregulated in macrophages, we identified a S-glutathionylation modification-related lncRNA (lncRNA-GM) which promotes antiviral type I interferon (IFN-I) production enhancing TBK1 kinase activity. Mechanistically, lncRNA-GM bound glutathione S-transferase M1 (GSTM1) and blocked its interaction with TBK1, thus...