A5044642052- interferon and immune responses
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Virus-based gene therapy research
- Immune Cell Function and Interaction
- RNA Interference and Gene Delivery
- Cancer, Hypoxia, and Metabolism
- Immune Response and Inflammation
- Pancreatic function and diabetes
- Immune cells in cancer
- Monoclonal and Polyclonal Antibodies Research
- NF-κB Signaling Pathways
- Viral Infectious Diseases and Gene Expression in Insects
- Circular RNAs in diseases
- Cytokine Signaling Pathways and Interactions
- Epigenetics and DNA Methylation
- Inflammasome and immune disorders
- Medicinal Plant Pharmacodynamics Research
- Viral Infections and Immunology Research
- Biological Stains and Phytochemicals
- Cell death mechanisms and regulation
- Liver Disease Diagnosis and Treatment
- Gut microbiota and health
- Diet and metabolism studies
- RNA Research and Splicing
Fudan University
2007-2025
Collaborative Innovation Center of Chemistry for Energy Materials
2024-2025
Wuhan Institute of Technology
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
University of Minnesota System
2022-2023
Aero Engine Corporation of China (China)
2022-2023
China Agricultural University
2018
Fox Chase Cancer Center
2015
Beijing National Laboratory for Molecular Sciences
2012
Tsinghua University
2009-2011
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide with limited therapeutic options. HCC-induced immunosuppression often leads to ineffectiveness immuno-promoting therapies. Currently, suppressing suppressors has become potential strategy for cancer immunotherapy. So, figuring out immunosuppressive mechanisms induced and employed by HCC will be helpful design application Here, we identified new subset human CD14+CTLA-4+ regulatory dendritic cells (CD14+DCs) in...
High-calorie food leads to nonalcoholic fatty liver disease (NAFLD) through dysregulation of genes involved in lipid metabolism, but the precise mechanism remains unclear. DNA methylation represents one mechanisms that contributes gene expression via interaction with environmental factors. Berberine can alleviate db/db and ob/ob mice. Here, we investigated whether is pathogenesis NAFLD induced by a high-fat diet (HFD) berberine improves influencing status promoters key genes. HFD markedly...
NK cells are important innate immune with potent cytotoxicity that can be activated by type I IFN from the host once infected. How cell is and then tightly regulated remain to fully elucidated. MicroRNAs (miRNAs, or miRs) regulators of response, but full scale miRNome in human remains determined. In this study, we reported an in-depth analysis miRNomes resting IFN-α-activated cells, found two abundant miRNAs, miR-378 miR-30e, markedly decreased IFN-α, further proved miR-30e directly targeted...
Long noncoding RNAs (lncRNAs) involved in the regulation of antiviral innate immune responses need to be further identified. By functionally screening lncRNAs macrophages, here we identified lncRNA
Significance Upon virus infection, host cells detect viral nucleic acids and initiate antiviral innate immune responses by producing type I IFNs proinflammatory cytokines. As a cytoplasmic sensor for RNA viruses, retinoic acid-inducible gene 1 (RIG-I) recognizes the pathogenic RNAs activates downstream signaling initiation of immunity. In this study, we identify RING finger protein 122 (RNF122) as an E3 ligase that directly binds to RIG-I induce K48-linked ubiquitination mediate degradation,...
Age-associated immune dysfunction, characterized by increased systemic levels of cytokines, manifests as an susceptibility to infections. Thus, understanding these negative regulators the response has paved way delineating signaling pathways that impact senescence. In present study, we found miR-146a, which negatively regulated expression IL-1β and IL-6, was highly expressed in aged mice. However, there a lack stimulation lipopolysaccharide (LPS) proinflammatory cytokines macrophages As...
Abstract Regulatory T (Treg) cells are important for the maintenance of immune homoeostasis and prevention autoimmune diseases. Epigenetic modifications have been reported to modulate autoimmunity by altering Treg cell fate. Here we show that H3K4 methyltransferase Ash1l facilitates TGF-β-induced polarization in vitro protects mice from cell-mediated colitis vivo . upregulates Smad3 expression directly targeting promoter increase local trimethylation. Furthermore, identify an lncRNA, namely...
Obesity-dependent insulin resistance and type 2 diabetes mellitus are closely associated with decreased glucose utilization down-regulation of hepatic glycolytic enzymes expression. Previously, we showed that DNA hypermethylation is involved in age-dependent susceptibility to diabetes. However, what cannot distinguish whether the age-related obesity contributes those natural aging rats. In present study, hypothesize methylation plays a crucial role regulation high-fat diet-induced obesity....
Dendritic cells (DCs) are critical to initiate the immune response and maintain tolerance, depending on different status subsets. The expression profiles of microRNAs (miRNAs) in various DC subsets haematopoietic stem (HSCs), which generate DCs, remain be fully identified. Here we examine miRNomes mouse bone marrow HSCs, immature mature DCs IL-10/NO-producing regulatory by deep sequencing. We identify numerous stage-specific miRNAs histone modification HSCs at differentiation stages....
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising candidate for cancer therapy, because it can induce apoptosis in various tumor cells but not most normal cells. Although well known that TRAIL and its receptors are expressed many types of cells, including immune their immunological effects regulatory mechanisms still obscure. In the present study, we demonstrated affected activity NF-κB (nuclear factor-κB) expression downstream proinflammatory cytokines IL-1β...
Significance Epithelial cell–mediated chemokine production and subsequent neutrophil recruitment are important for pathogen clearance, which, however, also closely related to severe inflammatory tissue damage during lung infection, especially influenza virus infection the current pandemic coronavirus infection. Certain regulation underlying mechanisms of expression in epithelial cells remain largely unknown. Here, by identifying mouse long noncoding RNA lnc-Cxcl2 human lnc-CXCL2-4-1...
ABSTRACT With the development of artificial neural networks (ANNs), its applications in chemistry have become increasingly widespread, especially prediction various molecular properties. This work introduces X2‐PEC method, that is, second generalization X1 series ANN methods developed our group, utilizing pair energy correction (PEC). The essence X2 model lies feature vector construction, using overlap integrals and core Hamiltonian to incorporate physical chemical information into vectors...
As part of aetiological studies, we tested 28 samples collected from domestic geese showing enteritis and sporadic death. A novel group avastroviruses was found in six samples. One isolate completely sequenced, which comprised 7,148 nucleotides. Pairwise comparisons phylogenetic analysis demonstrated that the goose astrovirus is highly divergent all previously described avastroviruses. Our data support view can be infected by astroviruses with different genetic backgrounds, have raised a...
Summary In many types of tumours, especially pancreatic adenocarcinoma, miR‐301a is over‐expressed. This over‐expression results in negative regulation the target gene miR‐301a, nuclear factor‐κB ( NF ‐κB) repressing factor NKRF ), increasing activation ‐κB and production ‐κB‐responsive pro‐inflammatory cytokines such as interleukin‐8, interferon‐β, nitric oxide synthase 2A cytochrome oxidase subunit 2 COX ‐2). However, immune cells, mechanisms that regulate have not been reported. Similar...
Tumor necrosis factor‐related apoptosis‐inducing ligand ( TRAIL ) is considered a promising agent for cancer therapy, as this molecule induces apoptosis specifically in various cells. Apart from apoptosis, also non‐apoptotic signals, such those autophagy, proliferation and metastasis In the present study, we report that suppressed CXCR 4‐mediated human breast MDA ‐ MB ‐231 cell migration by up‐regulating miR‐146a expression through NF ‐κB. receptor 1 ‐R1, DR 4) was highly expressed ‐treated...
Interferon regulatory factor 3 (IRF3) is an essential transductor for initiation of many immune responses. Here, we show that lncRNA-ISIR directly binds IRF3 to promote its phosphorylation, dimerization, and nuclear translocation, along with enhanced target gene productions. In vivo deficiency results in reduced IFN production, uncontrolled viral replication, increased mortality. The human homolog, AK131315, also promotes activation. More important, AK131315 expression positively correlated...
As one of the core components switching or sucrose non-fermentable (SWI/SNF) complex, SMARCC1 (BAF155, SRG3) plays essential roles in activation late inflammatory genes response to microbial challenge. However, little is known about mechanism how regulates innate response. Via functional screening, we identify nuclear E3 ubiquitin ligase RNF138 as a negative regulator and show that interacts with mediates its K48-linked polyubiquitination at position Lys643 proteasomal degradation. result,...
Abstract Gene-viral therapy, which uses replication-selective transgene-expressing viruses to manage tumors, can exploit the virtues of gene therapy and virotherapy overcome limitations conventional therapy. Using a human telomerase reverse transcriptase-targeted replicative adenovirus as an antiangiogenic transfer vector target new angiogenesis making use its unrestrained proliferation are completely concepts in tumor management. CNHK300-mE is selective replication constructed carry mouse...
Abstract Purpose: Therapeutic monoclonal antibody is increasingly applied in many clinical applications, although complicated technologies and high cost still limit their wide applications. To obtain the sustained serum concentration with one single injection lower of protein therapy, an adenovirus-mediated full-length gene therapy was developed. Experimental Design: Full-length light-chain heavy-chain sequences were linked internal ribosome entry site constructed into adenoviral vector...