A5100713724- MicroRNA in disease regulation
- Plant Molecular Biology Research
- Cancer-related molecular mechanisms research
- Air Quality and Health Impacts
- Photosynthetic Processes and Mechanisms
- Carcinogens and Genotoxicity Assessment
- Nitrogen and Sulfur Effects on Brassica
- Smoking Behavior and Cessation
- Genetic Mapping and Diversity in Plants and Animals
- Indoor Air Quality and Microbial Exposure
- Bioinformatics and Genomic Networks
- Circular RNAs in diseases
- RNA modifications and cancer
- Plant Water Relations and Carbon Dynamics
- Plant Reproductive Biology
- Quantum Dots Synthesis And Properties
- Lipid metabolism and biosynthesis
- Atherosclerosis and Cardiovascular Diseases
- Perovskite Materials and Applications
- Legume Nitrogen Fixing Symbiosis
- Forest ecology and management
- Gene expression and cancer classification
- Molecular Biology Techniques and Applications
- Computational Drug Discovery Methods
- Plant nutrient uptake and metabolism
Peking University
2002-2025
Army Medical University
2025
Central South University
2016-2025
Swinburne University of Technology
2025
Southwest Hospital
2025
Xi'an University of Science and Technology
2014-2025
Philip Morris International (Switzerland)
2014-2024
Peking Union Medical College Hospital
2023-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2024
Guiyang College of Traditional Chinese Medicine
2024
Plant axillary meristems are composed of highly organized, self-renewing stem cells that produce indeterminate branches or terminate in differentiated structures, such as the flowers. These opposite fates, dictated by both genetic and environmental factors, determine interspecific differences architecture plants. The Cys(2)-His(2) zinc-finger transcription factor RAMOSA1 (RA1) regulates fate most during early development maize inflorescences, tassel ear, has been implicated evolution grass...
Organotypic culture of human primary bronchial epithelial cells is a useful in vitro system to study normal biological processes and lung disease mechanisms, develop new therapies, assess the perturbations induced by environmental pollutants. Herein, we investigate whether cigarette smoke (CS) observed epithelium smokers' airways are reproducible this (AIR-100 tissue), which has been shown recapitulate most characteristics epithelium. Human AIR-100 tissues were exposed mainstream CS for 7,...
Jacalin-related lectins (JRLs) are a subgroup of proteins with one or more jacalin-like lectin domains. Although JRLs often associated biotic abiotic stimuli, their biological functions in plants, as well relationships to plant disease resistance, poorly understood. A mannose-specific JRL (mJRL)-like gene (TaJRLL1) that is mainly expressed stem and spike encodes protein two domains was identified wheat. Pathogen infection phytohormone treatments induced its expression; while application the...
While the toxicity of main constituents electronic cigarette (ECIG) liquids, nicotine, propylene glycol (PG), and vegetable glycerin (VG), has been assessed individually in separate studies, limited data on inhalation them is available when mixtures. In this 90-day subchronic study, Sprague-Dawley rats were nose-only exposed to filtered air, nebulized vehicle (saline), or three concentrations PG/VG mixtures, with without nicotine. Standard toxicological endpoints complemented by molecular...
Abstract Motivation: After more than a decade since microarrays were used to predict phenotype of biological samples, real-life applications for disease screening and identification patients who would best benefit from treatment are still emerging. The interest the scientific community in identifying approaches develop such prediction models was reaffirmed competition style international collaboration called IMPROVER Diagnostic Signature Challenge whose results we describe herein. Results:...
High-throughput measurement technologies such as microarrays provide complex datasets reflecting mechanisms perturbed in an experiment, typically a treatment vs. control design. Analysis of these information rich data can be guided based on priori knowledge, networks or set related proteins genes. Among those, cause-and-effect network models are becoming increasingly popular and more than eighty models, describing processes involved cell proliferation, fate, stress, inflammation have already...
Age-associated immune dysfunction, characterized by increased systemic levels of cytokines, manifests as an susceptibility to infections. Thus, understanding these negative regulators the response has paved way delineating signaling pathways that impact senescence. In present study, we found miR-146a, which negatively regulated expression IL-1β and IL-6, was highly expressed in aged mice. However, there a lack stimulation lipopolysaccharide (LPS) proinflammatory cytokines macrophages As...
The objective of the study was to characterize toxicity from sub-chronic inhalation test atmospheres candidate modified risk tobacco product (MRTP), Tobacco Heating System version 2.2 (THS2.2), and compare it with that 3R4F reference cigarette. A 90-day nose-only on Sprague-Dawley rats performed, combining classical systems toxicology approaches. Reduction in respiratory minute volume, degree lung inflammation, histopathological findings tract organs were significantly less pronounced...
Various electronic nicotine delivery systems (ENDS), of which cigarettes (e-cigs) are the most recognized prototype, have been quickly gaining ground on conventional because they perceived as less harmful. Research assessing potential effects ENDS exposure in humans is currently limited and inconclusive. New products emerging with numerous variations designs performance parameters within across brands. Acknowledging these challenges, we present here a proposed framework for an vitro...
Plant height (PH), branch initiation (BIH), and stem diameter (SD) are three stem-related traits that play crucial roles in plant architecture lodging resistance. Herein, we show one doubled haploid (DH) population obtained from a cross between Y689 (one Capsella bursa-pastoris derived Brassica napus intertribal introgression) Westar (B. cultivar) these were significantly positively correlated with another flowering time (FT). Based on high-density SNP map, total of 102 additive quantitative...
To address the global demand for rapeseed while considering farmers' profit, we face challenges of making a quantum leap in seed yield and, at same time, reducing loss due to biotic and abiotic stresses. We also challenge efficiently applying new transformative biotechnology tools such as gene editing breeding by genome design increase productivity profitability. In this Perspective, review advances research on physiological genetic bases both stress factors-affected stability potential,...
Cryptochromes (CRYs) are blue light receptors important for plant growth and development. Comprehensive information on monocot CRYs is currently only available rice (Oryza sativa). We report here the molecular functional characterization of two CRY genes, TaCRY1a TaCRY2, from wheat (Triticum aestivum). The expression was most abundant in seedling leaves barely detected roots germinating embryos under normal conditions. TaCRY2 equivalent to that much higher than counterpart. Transition dark...
Towards a systems toxicology-based risk assessment, we investigated molecular perturbations accompanying histopathological changes in 28-day rat inhalation study combining transcriptomics with classical histopathology. We demonstrated reduced biological activity of prototypic modified tobacco product (pMRTP) compared the reference research cigarette 3R4F. Rats were exposed to filtered air or three concentrations mainstream smoke (MS) from 3R4F, high concentration MS pMRTP. Histopathology...
Smoking has been associated with diseases of the lung, pulmonary airways and oral cavity. Cytologic, genomic transcriptomic changes in mucosa correlate pre-neoplasia, cancer inflammation (e.g. periodontitis). Alteration smoking-related gene expression epithelial cells is similar to that bronchial nasal cells. Using a systems toxicology approach, we have previously assessed impact cigarette smoke (CS) seen as perturbations biological processes human organotypic culture models. Here, report...
This study reports a comparative assessment of the biological impact heated tobacco aerosol from heating system (THS) 2.2 and smoke combustible 3R4F cigarette. Human organotypic bronchial epithelial cultures were exposed to an THS2.2 (a candidate modified-risk product) or at similar nicotine concentrations. A systems toxicology approach was applied enable comprehensive exposure assessment. Culture histology, cytotoxicity, secreted pro-inflammatory mediators, ciliary beating, genome-wide...
Organotypic 3D cultures of epithelial cells are grown at the air-liquid interface (ALI) and resemble in vivo counterparts. Although complexity cellular responses could be better manifested coculture models which additional cell types such as fibroblasts were incorporated, presence another type mask response other. This study reports impact whole cigarette smoke (CS) exposure on organotypic mono- to evaluate relevancy for toxicological assessment aerosols. Two bronchial directly exposed low...
Sclerotinia stem rot (SSR) caused by sclerotiorum (Lib.) de Bary is one of the most devastating diseases Brassica napus worldwide. Both SSR resistance and flowering time (FT) adaptation are major breeding goals in B. napus. However, early maturing rapeseed varieties, which important for rice-rapeseed rotation China, often highly susceptible to SSR. Here, we found that was significantly negatively correlated with FT a natural population containing 521 inbred lines double haploid (DH) 150...
Smoking cigarettes is harmful to the cardiovascular system. Considerable attention has been paid reduced harm potential of alternative nicotine-containing inhalable products such as e-cigarettes. We investigated effects E-vapor aerosols or cigarette smoke (CS) on atherosclerosis progression, function, and molecular changes in heart aorta female apolipoprotein E-deficient (ApoE-/-) mice. The mice were exposed from three different formulations: 1) carrier (propylene glycol vegetable glycerol),...
Making artificial bile ducts in vitro for repairing and replacing diseased is an important concept tissue engineering. This study printed a tubular composite scaffold using polycaprolactone (PCL) through the current 3D printing method. It served as matrix organoid cells of duct to proliferation, migration, differentiation. The PCL full duct-like organ can achieve effect bionics, original perform its proper function. In order enrich performance scaffold, hydrogels were also used this study....