A5065604851- Power Systems and Technologies
- Smart Grid and Power Systems
- Power Systems Fault Detection
- Plant tissue culture and regeneration
- Advanced Computational Techniques and Applications
- Power Systems and Renewable Energy
- High-Voltage Power Transmission Systems
- Plant Stress Responses and Tolerance
- RNA modifications and cancer
- Plant-Microbe Interactions and Immunity
- Plant Micronutrient Interactions and Effects
- Transgenic Plants and Applications
- HVDC Systems and Fault Protection
- MicroRNA in disease regulation
- Power System Optimization and Stability
- Islanding Detection in Power Systems
- Plant Virus Research Studies
- Optimal Power Flow Distribution
- Radiomics and Machine Learning in Medical Imaging
- Electrical Fault Detection and Protection
- Plant Molecular Biology Research
- Medical Imaging Techniques and Applications
- Advanced Sensor and Control Systems
- Cancer-related molecular mechanisms research
- Biofuel production and bioconversion
Lanzhou University
2024-2025
Lanzhou University Second Hospital
2024-2025
Guizhou University
2016-2025
Guangxi Medical University
2025
Sun Yat-sen University
2013-2024
Sun Yat-sen Memorial Hospital
2014-2024
Air Force Engineering University
2023
Chengdu University
2023
State Key Laboratory of Silkworm Genomic Biology
2022
Southwest University
2020-2022
Long intergenic non-protein-coding RNA 152 (LINC00152) is one of the long noncoding RNAs (lncRNAs) abnormally expressed in gastric cancer tissues. However, its value diagnosis unclear. The aim this study to evaluate clinical significance plasma LINC00152 as a biomarker screening and explore possible mechanism underling stable existence blood. We analyzed levels patients with epithelial dysplasia healthy controls using quantitative reverse transcription polymerase chain reaction then...
Microglia are important for secreting chemical mediators of inflammatory responses in the central nervous system. Interleukin (IL)-10 and IL-1β secreted by glial cells support neuronal functions, but related mechanisms remain vague. Our goal was to demonstrate efficacy IL-10 suppressing inflammasome activation mice with epileptic seizure based on an epileptic-seizure mouse model.In this study, which seizures were induced administering picrotoxin (PTX) used as a case group, injected saline...
// Jian-Jun Lu 1, * , Lingyi Fu 2, 3, Zhipeng Tang 4, Changlin Zhang 2 Lijun Qin 5 Jingshu Wang Zhenlong Yu 4 Dingbo Shi Xiangsheng Xiao Fangyun Xie Wenlin Huang 6 Wuguo Deng 1 Department of Thoracic Surgery, The First Affiliated Hospital, Yat-sen University, Guangzhou, China Sun University Cancer Center, State Key Laboratory Oncology in South China, Collaborative Innovation Center Medicine, 3 Guangdong General Academy Medical Sciences, Institute Stem Cell, Dalian Dalian, Pediatrics,...
NRAMP family genes participate in the absorption and transport of heavy metals such as cadmium (Cd), zinc (Zn), copper (Cu), lead (Pb), iron (Fe) manganese (Mn) play an important role response to metal stress. There is abundance research on these bacteria, plants fungi, although not S. tuberosum. A total 48 members(potato(5), Arabidopsis(7), Tomato(9), pepper(9), rice(12) tobacco(6)) were identified from 6 species (potato (Solanum tuberosum), Arabidopsis thaliana, Tomato lycopersicum),...
// Lijun Qin 1,* , Yun Tian 2,3,4,5,* Zhenlong Yu 6,* Dingbo Shi 2,3,4 Jingshu Wang Changlin Zhang Ruoyu Peng 7 Xuezhen Chen 1 Congcong Liu 6 Yiming Wenlin Huang 2,3,4,8 and Wuguo Deng Department of Pediatrics, Sun Yat-sen Memorial Hospital, University, Guangzhou, China 2 University Cancer Center, 3 State Key Laboratory Oncology in South China, 4 Collaborative Innovation Center Medicine, 5 Guangzhou Women Children's Medical Institute Stem Cell, Dalian Dalian, Guangdong Provincial No....
Abstract Background As the selective inhibitor of BRAF kinase, vemurafenib exhibits effective antitumor activities in patients with V600 mutant melanomas. However, acquired drug resistance invariably develops after its initial treatment. Methods Immunohistochemical staining was performed to detect expression iNOS and hTERT, p-p65, Epcam, CD44, PCNA mice melanoma xenografts. The proliferation migration cells were detected by MTT, tumorsphere culture, cell cycle, apoptosis, AO/EB assay colony...
Plants have evolved a number of defense and adaptation responses to protect themselves against challenging environmental stresses. Genes containing heavy metal associated (HMA) domain are required for the spatiotemporal transportation ions that bind with various enzymes co-factors within cell. To uncover underlying mechanisms mediated by StHMA genes, we identified 36 gene members in family divided them into six subfamilies phylogenetic analysis. The StHMAs had high collinearity were...
Pig is an important agricultural animal for meat production and provides a valuable model many human diseases. Functional studies have demonstrated that microRNAs (miRNAs) play critical roles in almost all aspects of skeletal muscle development disease pathogenesis. To investigate the miRNAs involved regulating different periods development, we herein performed comprehensive research porcine microRNAome (miRNAome) during 10 developmental stages including 35, 49, 63, 77, 91 dpc (days post...
Plant growth-promoting bacteria (PGPB) can promote plant growth in various ways, allowing PGPB to replace chemical fertilizers avoid environmental pollution. is also used for bioremediation and pathogen control. The isolation evaluation of are essential not only practical applications, but basic research. Currently, the known strains limited, their functions fully understood. Therefore, mechanism needs be further explored improved. Bacillus paralicheniformis RP01 strain with beneficial...
Abstract Aims To determine the optimum conditions for extracting Eucommia ulmoides gum (EUG) from leaves during fermentation by Coprinellus disseminatus. At same time, EUG characteristics were characterized. Methods and results The ability of C. disseminatus to secrete degrading enzymes, including enzyme activity lignocellulose content, was observed culturing on a medium with different formulations. Based optimal formula, determined an orthogonal test extracted. After that, characteristic...
Introduction Cerebral ischemia–reperfusion (IR) causes severe secondary brain injury. Previous studies have demonstrated that ferroptosis is involved in IR-induced However, whether IR induces microvascular endothelial cells (BMVECs) not fully understood. Materials and methods Oxygen–glucose deprivation/reoxygenation (OGDR) was performed bEND.3 to mimic injury vitro , a focal cerebral model created C57BL/6 mice. Transcriptomic sequencing of the first, followed by bioinformatics analysis....
RNA methylation is a potential target for cancer therapy, while anoikis, form of programmed cell death, linked to metastasis. However, the prognostic and immune significance methylation- anoikis-related genes in colorectal (CRC) remains unknown. Transcriptomic clinicopathological data CRC were obtained from TCGA GEO databases. A novel signature was constructed based on using univariate multivariate Cox regression as well LASSO methods. patients stratified into low- high-risk groups this...
Differentiation of 3T3‐L1 cells into adipocytes involves a highly orchestrated series complex events in which microRNAs might play an essential role. In this study, we found that the overexpression microRNA‐344 (miR‐344) inhibits cell differentiation and decreases triglyceride accumulation after MDI stimulation. We demonstrated miR‐344 directly targets 3′ UTR GSK3β (Glycogen synthase kinase 3 beta). Knockdown with siRNA results inhibiting differentiation, while its restores effect miR‐344....
Acute myeloid leukemia (AML) with an internal tandem duplication in Fms-related tyrosine kinase 3 (FLT3-ITD) is identified as a subgroup poor outcome and intrinsic resistance to chemotherapy therefore urgent need for development of novel therapeutic strategies. Methods: The antitumor effects melatonin alone or combined sorafenib were evaluated via flow cytometry immunoblotting assays FLT-ITD AML cells. Also, the ex vivo models used test synergistic against FLT3/ITD mutation. Results: Our...
Plant growth-promoting bacteria (PGPB) are components of the plant rhizosphere that promote growth and/or inhibit pathogen activity. To explore cotton seedlings response to Bacillus circulans GN03 with high efficiency promotion and disease resistance, a pot experiment was carried out, in which inoculations levels were set at 10 4 8 cfu ⋅ mL –1 . The results showed inoculation remarkably enhanced as well resistance seedlings. altered microbiota around roots, led significant accumulation...
// Yun Tian 1, * , Lijun Qin 3, Huijuan Qiu Dingbo Shi 1 Rui Sun Wenbing Li Tianze Liu Jingshu Wang Tingting Xu 4 Wei Guo Tiebang Kang Wenlin Huang 5 Guowen 2, Wuguo Deng 5, Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center Medicine, Guangzhou, China 2 Department Bone and Soft Tissue Tumors, Tianjin Medical Institute Hospital, National Clinical Research for Cancer, Prevention Therapy, Tianjin, 3 Pediatrics, Memorial University,...
The elevated expression and activation of human telomerase reverse transcriptase (hTERT) is associated with the unlimited proliferation cancer cells. However, excise mechanism hTERT regulation during carcinogenesis not well understood. In this study, we discovered cleavage polyadenylation specific factor 4 (CPSF4) as a novel tumor‐specific promoter‐regulating protein in lung cells identified roles CPSF4 regulating growth. ectopic overexpression upregulated promoter‐driven report gene...