A5100345656- Ovarian function and disorders
- Reproductive Biology and Fertility
- Assisted Reproductive Technology and Twin Pregnancy
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Reproductive Health and Technologies
- Ovarian cancer diagnosis and treatment
- RNA modifications and cancer
- Ectopic Pregnancy Diagnosis and Management
- Sexual Differentiation and Disorders
- Cancer Immunotherapy and Biomarkers
- Glioma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Acute Lymphoblastic Leukemia research
- PARP inhibition in cancer therapy
- Childhood Cancer Survivors' Quality of Life
- Gynecological conditions and treatments
- Prenatal Screening and Diagnostics
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Nosocomial Infections in ICU
- Inflammasome and immune disorders
- Autoimmune Neurological Disorders and Treatments
- Adrenal Hormones and Disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Sun Yat-sen Memorial Hospital
2015-2024
Sun Yat-sen University
2015-2024
Memorial
2024
Guangxi Medical University
2023
Chongqing University
2022
Chongqing Cancer Hospital
2022
Tianjin Medical University General Hospital
2022
Air Force Medical University
2019-2021
Xijing Hospital
2019-2021
Beijing Anzhen Hospital
2020
Microglia are important for secreting chemical mediators of inflammatory responses in the central nervous system. Interleukin (IL)-10 and IL-1β secreted by glial cells support neuronal functions, but related mechanisms remain vague. Our goal was to demonstrate efficacy IL-10 suppressing inflammasome activation mice with epileptic seizure based on an epileptic-seizure mouse model.In this study, which seizures were induced administering picrotoxin (PTX) used as a case group, injected saline...
: Prostate specific membrane antigen (PSMA) is specifically expressed on prostate epithelial cells and markedly overexpressed in almost all cancers. TRIM24 also up-regulated from localized cancer to metastatic castration-resistant (CRPC). Because of the high relevance for development universal expression PSMA CPRC, we investigated efficacy human monoclonal antibody (PSMAb)-based platform targeted siRNA delivery its therapeutic CRPC
The preservation of the replicative life span memory CD8(+) T cells is vital for long-term immune protection. Although IL-15 plays a key role in homeostasis cells, it unknown whether regulates cells. In this study, we report an analysis telomerase expression and telomere length human phenotype maintained by vitro. We demonstrate that capable activating via Jak3 PI3K signaling pathways. Furthermore, induces sustained level activity over long periods time, turn minimizes loss after substantial...
This retrospective study is to compare the follicular mild stimulation and luteal simulation protocols for poor responders undergoing in vitro fertilization (IVF). A total of 131 women were diagnosed as responders. Thirty-three started ovarian early-luteal phase 98 early with 100 mg/d clomiphene citrate 75–150 IU/d HMG. There more oocytes retrieved (2.8 ± 2.0 versus 1.2, p < 0.05), available embryos (1.8 1.4 1.3 1.1, 0.05) top-quality (0.9 0.9 0.4 0.6, reduced cycle cancellation rate (12.1%...
Similar to retro−/lenti- virus system, DNA transposons are useful tools for stable expression of exogenous genes in mammalian cells. Sleeping Beauty (SB) transposon has adopted integrating into host genomes recent studies. However, SB-derived vector system proteins purifying/tracking and gene knockout still not available. In this study, we generated a series vectors (termed as pSB vectors) containing IRDR-L/R that can be transposed by SB transposase. Gateway cassette was combined the...
To determine the normative cut-off value for free androgen index (FAI) among reproductive-age women in China.Cross-sectional, population-based study.A multistage systematic cluster random sampling 16 communities from two rural and city regions.A total of 1526 were randomly selected a representative sample 3009 aged 20-45 years general population southern China. Among these women, 444 subjects without known factors affecting levels as reference group.Subjects underwent physical examination,...
To determine if the GnRH antagonist protocol is effective in preventing ovarian hyperstimulation syndrome (OHSS) potentially high responders.A total of 660 IVF-ET/ICSI cycles were retrospectively identified. The inclusion criterion was age ≤ 30 years. Cycles divided into two groups: a GnRHa group and GnRHant group. In group, patients received one single injection 1.0mg-1.3mg Triptorelin previous mid-luteal phase. daily dose 0.25 mg Cetrotide initiated when lead follicle obtained mean...
This hospital-based observational study aims to estimate differences in metabolic abnormalities between different polycystic ovary syndrome (PCOS) phenotypes and their distribution characteristics. The prevalence of among PCOS phenotypes, including diabetes mellitus (DM), (MS), pre-diabetes (pre-DM), insulin resistance (IR) dyslipidemia were compared. A total 2436 women who ≥18 years old hospitalized Sun Yat-Sen University affiliated hospital from 1998 2015 GuangZhou, China, included this...
Background: Renal cell carcinoma (RCC) is the most common malignancy in urinary system. Despite substantial improvements available treatment options, survival outcome of advanced RCC unsatisfactory. Identifying novel biomarkers to assist early diagnosis and screen patients who are sensitive immunotherapy would be beneficial. CD248 a promising candidate that deserves investigated. Methods: The Cancer Genome Atlas (TCGA) data set clinical specimens were adopted analyze expression between...
Background. Single-nucleotide polymorphisms (SNPs) in the follicle stimulating hormone receptor (FSHR) gene are associated with PCOS. However, their relationship to polycystic ovary (PCO) morphology remains unknown. This study aimed investigate whether PCOS related SNPs FSHR PCO women Methods . Patients were grouped into (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>384</mml:mn></mml:math>) and non-PCO...
Rationale: Neoadjuvant chemotherapy has become the standard treatment of locally advanced breast cancer. Antimicrotubule drugs and DNA-damaging are most popular medicines used for neoadjuvant chemotherapy. However, we unable to predict which chemotherapeutic drug will benefit an individual patient. PARK2 as a tumor suppressor in cancer been reported. While role response remains unknown. In this study, explore impact on chemosensitivity Methods: expression patients with different regimens was...
To determine the prevalence, clinical and imaging features of intimal tear detected by ECG-gated multidetector computed tomography (MDCT) confirmed surgery in patients with acute type A intramural hematoma (ATAIMH) aortic dissection (AAAD).This retrospective study involved analysis characteristics 72 consecutive ATAIMH 209 AAAD who were diagnosed MDCT. The size location measured compared between these two groups patients. findings also those from 28 underwent surgical treatment to as...
There is no absolute consensus for the best time triggering. The aim of this study was to investigate effect different proportion dominant follicles (PDF) on human chorionic gonadotropin (HCG) day clinical outcomes in patients with polycystic ovary syndrome (PCOS) ovarian stimulation protocols.A total 371 cycles gonadotropin-releasing hormone (GnRH) agonist long protocol and 347 GnRH antagonist from January 2014 December 2016 were included retrospective study. Based PDF HCG administration,...
Abstract STUDY QUESTION Does an artificially induced FSH surge at the time of hCG trigger improve IVF/ICSI outcomes? SUMMARY ANSWER An additional bolus administered has no effect on clinical pregnancy rate, embryo quality, fertilization implantation rate and live birth in women undergoing long GnRH agonist (GnRHa) protocol for IVF/ICSI. WHAT IS KNOWN ALREADY Normal ovulation is preceded by a both LH FSH. Few randomized trials have specifically investigated role surge. Some studies indicated...
Although emerging animal- or cell-based evidence supports the relationship between casein kinase 2 alpha protein 1 (CSNK2A1) and cancers, no pan-cancer analysis is available. Thus, this report aimed to display prognostic landscape of CSNK2A1 in investigate tumor immunity. In current study, we investigated expression pattern, genetic alterations survival across multiple datasets online platforms. The correlations immunity were explored visualized via R language software. Following this,...