A5100341113- Immune Cell Function and Interaction
- Immune Response and Inflammation
- interferon and immune responses
- Aquaculture disease management and microbiota
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Vibrio bacteria research studies
- Cytokine Signaling Pathways and Interactions
- Reproductive System and Pregnancy
- Invertebrate Immune Response Mechanisms
- Immune cells in cancer
- Viral Infections and Vectors
- RNA Interference and Gene Delivery
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- IL-33, ST2, and ILC Pathways
- Toxin Mechanisms and Immunotoxins
- NF-κB Signaling Pathways
- Antimicrobial Peptides and Activities
- Galectins and Cancer Biology
- Complement system in diseases
- Ubiquitin and proteasome pathways
- Inflammasome and immune disorders
- Toxoplasma gondii Research Studies
- Plant Pathogenic Bacteria Studies
- vaccines and immunoinformatics approaches
Institute of Hydrobiology
2016-2025
Chinese Academy of Sciences
2016-2025
Hebei Medical University
2025
State Key Laboratory of Freshwater Ecology and Biotechnology
2019-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2023
Second Military Medical University
2001-2023
Guangzhou Medical University
2017-2023
Eastern Hepatobiliary Surgery Hospital
2023
Affiliated Hospital of Shaanxi University of Chinese Medicine
2021-2023
Third Affiliated Hospital of Guangzhou Medical University
2023
The testis presents a special immunological environment, considering its property of immune privilege that tolerates allo- and auto-antigens. Testicular was once believed to be mainly based on the sequestration antigens from system by blood-testis barrier in seminiferous epithelium. Substantial evidence supports view combination physical structure, testicular cells, cytokines controls responses preserve structural functional integrity privilege. Both systemic tolerance local...
NK cells are important innate immune with potent cytotoxicity that can be activated by type I IFN from the host once infected. How cell is and then tightly regulated remain to fully elucidated. MicroRNAs (miRNAs, or miRs) regulators of response, but full scale miRNome in human remains determined. In this study, we reported an in-depth analysis miRNomes resting IFN-α-activated cells, found two abundant miRNAs, miR-378 miR-30e, markedly decreased IFN-α, further proved miR-30e directly targeted...
The classical activation of macrophages, one major innate effector cells, requires IFN-γ pretreatment (priming) and subsequent TLR stimuli (triggering). priming effect can promote macrophages to secrete higher level proinflammatory cytokines but lower the anti-inflammatory cytokines, enhancing microbicidal tumoricidal activity macrophages. However, underlying molecular mechanisms for IFN-γ-priming on macrophage remain be fully understood. microRNAs (miRNAs) are now emerging as important...
Flavobacterium columnare, a member of the phylum Bacteroidetes, causes columnaris disease in wild and aquaculture-reared freshwater fish. The mechanisms responsible for are not known. Many members Bacteroidetes use type IX secretion systems (T9SSs) to secrete enzymes, adhesins, proteins involved gliding motility. F. columnare genome has all genes needed encode T9SS. gldN, which encodes core component T9SS, was deleted wild-type strains ΔgldN mutants were deficient several extracellular...
The skin of vertebrates is the outermost organ body and serves as first line defense against external aggressions. In contrast to mammalian skin, that teleost fish lacks keratinization has evolved operate a mucosal surface containing skin-associated lymphoid tissue (SALT). Thus far, IgT representing prevalent Ig in SALT have only been reported upon infection with parasite. However, very little known about types B cells Igs responding bacterial mucosa, well inductive or effector role such...
Highlights•Kdm5a promotes NK cell activation by regulating interferon-γ production•Kdm5a inhibits SOCS1 expression and STAT4 activation•Kdm5a is recruited to the promoter p50 maintain a repressive chromatin configuration•Kdm5a required for clearance of LmSummaryThe H3K4me3 demethylase Kdm5a regulates gene transcription implicated in carcinogenesis. However, role innate immune response remains poorly understood. Here, we demonstrate that deficiency impairs natural killer (NK) cells, with...
Abstract Memory CD8 + T cell generation is crucial for pathogen elimination and effective vaccination against infection. The cellular molecular circuitry that underlies the of memory cells remains elusive. Eosinophils can modulate inflammatory allergic responses interact with lymphocytes to regulate their functions in immune defense. Here we report eosinophils are required by inhibiting apoptosis. Eosinophil-deficient mice display significantly impaired response weakened resistance Listeria...
// Weiqun Lu 1, * , Jia Wang Guohua Yang 1 Nanrong Yu Zhiliang Huang Houwei Xu Jianchang Li Jiliang Qiu Xiang Zeng Shicai Chen Nan Haiying Liu Department of Gastrointestinal Neoplasms Surgery, Affiliated Cancer Hospital & Institute Guangzhou Medical University, 510095, Guangdong, China These authors contributed equally to this work Correspondence to: Li, email: linan_gz2013@163.com Liu, gzdlhy@sina.com Keywords: colorectal cancer, Galectin-3, miR-128, cancer progression Received: December...
Patients receiving epidural or intrathecal opioids administration for neuraxial analgesia frequently suffer from an irritating itch. STING (stimulator of interferon genes), innate immune modulator, is strongly implicated in pain pathogenesis via neuron-immune modulation. Given that and itch share some common neurocircuits, we evaluate the therapeutic potential agonists opioid-induced chronic itch.Opioids (morphine, fentanyl sufentanil) were intrathecally injected to induce acute Chronic was...
Tyro3, Axl and Mer (TAM) receptor tyrosine kinases triple knockout (TAM −/− ) mice are male infertile due to impaired spermatogenesis. However, the mechanism by which TAM receptors regulate spermatogenesis remains unclear. In this study, we demonstrate that testicular immune homeostasis was in mice. As development after onset of sexual maturity, germ cells were progressively degenerated. Macrophages lymphocytes infiltrated into testis as aged. Moreover, integrity blood–testis barrier...
The testis is an immunoprivileged site where local cell-initiated innate immunity plays a crucial role in antimicrobial responses. Toll-like receptors (TLRs) mediate immune responses testicular somatic cells. Although several TLRs are expressed some stages of male germ cells, the potential triggering cells has yet to be exclusively studied. current study demonstrates that TLR3 constitutively spermatogonia and spermatocytes can activated by synthetic double-strained RNA analog,...
The testis is an immune privileged organ in which the tissue-specific cells have adopted effective innate functions against microbial pathogens. Toll-like receptors (TLRs) mediate response testis. current study demonstrates that melanoma differentiation-associated protein 5 (MDA5) and retinoic acid-inducible gene I (RIG-I) initiate testicular antiviral response. Both MDA5 RIG-I are expressed Leydig cells, also spermatids. Polyinosinic-polycytidylic acid [poly(I:C)], a common agonist of...
In vertebrates, intron-containing and intronless type I IFN genes have recently been reported in amphibian model species Xenopus tropicalis X. laevis. However, whether IFNs amphibians are the ancestral of amniotes or just represent independent divergence is unknown even uninvestigated. this study, both genes, as well their receptor were identified Tibetan frog Nanorana parkeri The evidence obtained from homology, synteny, phylogeny, time showed that N. might arisen two retroposition events...
Mammalian CIITA isoforms are tightly regulated by independent promoters. These promotors induced IFN-γ through JAK-STAT signaling pathway. The induction of controls the expression MHC class II (MHCII) and Ag presentation to adaptive immune system. In current study, our knowledge, we first identified two promoters, p1 p2, in zebrafish (Danio rerio) that control variants CIITA, variant 1 (CIITAv1), 2 (CIITAv2), respectively. Moreover, although IRF1 an pathway CIITAv2, which has ISRE motifs its...
Abstract Cisplatin is one of the most potent chemotherapy drugs to treat cancers, but its clinical application remains limited due severe nephrotoxicity. Several approaches have been developed minimize such side effects, notably including chronotherapy, a well-known strategy based on circadian clock. However, component clock machinery that particularly responses cisplatin stimulation unknown, functions in cisplatin-induced renal injury. In our present study, we demonstrated Bmal1, as key...