A5100440050- Galectins and Cancer Biology
- Glycosylation and Glycoproteins Research
- Cancer Mechanisms and Therapy
- Atherosclerosis and Cardiovascular Diseases
- Signaling Pathways in Disease
- Chronic Lymphocytic Leukemia Research
- Cell Adhesion Molecules Research
- Phagocytosis and Immune Regulation
- Cardiac Fibrosis and Remodeling
- Histone Deacetylase Inhibitors Research
- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
- Ion channel regulation and function
- Pharmacological Effects of Natural Compounds
- Caveolin-1 and cellular processes
- Chemokine receptors and signaling
- Forensic Toxicology and Drug Analysis
- Plant-based Medicinal Research
- RNA modifications and cancer
- Endoplasmic Reticulum Stress and Disease
- Forensic and Genetic Research
- Dental Implant Techniques and Outcomes
- Cardiovascular Effects of Exercise
- Protein Tyrosine Phosphatases
- Molecular Biology Techniques and Applications
Shanghai Pulmonary Hospital
2021-2024
Tongji University
2021-2024
Guiyang Medical University
2017-2024
Anhui Medical University
2021
Henry Ford Health System
2016
New York Blood Center
2014
Peking University
2014
Histone deacetylase 6 (HDAC6) is a potential therapeutic target for treating several diseases. A recent study revealed that HDAC6 important NLRP3 inflammasome activation, suggesting targeting could be useful many inflammatory disorders. Using the proteolysis chimera (PROTAC) strategy, we herein report an degrader with low cytotoxicity by tethering selective inhibitor derived from natural product, indirubin, pomalidomide, CRBN E3 ligand. Our efficiently and selectively decreased levels in...
Mycobacterial arabinogalactan (AG) is an essential cell wall component of mycobacteria and a frequent structural bio-synthetical target for anti-tuberculosis (TB) drug development. Here, we report that mycobacterial AG recognized by galectin-9 exacerbates infection. Administration AG-specific aptamers inhibits cellular infiltration caused Mycobacterium tuberculosis (Mtb) or bovis BCG, moderately increases survival Mtb-infected mice marinum-infected zebrafish. interacts with carbohydrate...
This study was aimed at identifying molecular markers associated with the pathogenesis of sudden cardiac death (SCD). It provides a proteomic analysis human left anterior descending coronary artery from subjects diagnosed SCD through histological examination and cases nondisease accidental deaths autopsy. A total 2784 proteins were obtained label-free quantitative analysis. included 265 differential which involved in SCD-related processes, such as inflammation, muscle system process...
// Xilin Zhang 1,2,3 , Queping Liu 2,3 Jie Wang Guihua Li Matthew Weiland Fu-Shin Yu 4 Qing-Sheng Mi 2,3,5 Jun Gu 1 and Zhou Department of Dermatology, Second Military Medical University Changhai Hospital, Shanghai, China 2 Henry Ford Immunology Program, Health System, Detroit, MI, United States America 3 Anatomy Cell Biology, Wayne State School Medicine, 5 Internal Correspondence to: Gu, email: Mi, Zhou, Keywords : TIM-4, Langerhans cells, dendritic skin, skin-draining lymph node,...
Deeper understanding of the crosstalk between host cells and Mycobacterium tuberculosis (Mtb) provides crucial guidelines for rational design novel intervention strategies against (TB). Mycobacteria possess a unique complex cell wall with arabinogalactan (AG) as critical component. AG has been identified virulence factor Mtb which is recognized by galectin-9. Here, we demonstrate that galectin-9 directly inhibited mycobacterial growth through AG-binding property carbohydrate-recognition...
Abstract Three-point bending test, compression test and tensile can detect the mechanical properties of whole layer skull, but cannot inner plate, diploe outer plate skull. In this study, nanoindentation technology was applied to micro-materials differences in micro-mechanical inner, plates skull cranial suture human carcasses at different ages were analyzed. The hardness (HIT) modulus elasticity (E) statistically significant among age groups ( P < 0.01). terms structure, E higher than...
Improper use of strychnine can cause death. The aim this study was to identify and evaluate toxic mechanisms action associated with active compounds in using a network toxicology approach, explore potential pathogenic targets.In the present study, target central nervous system-related gene set were established Traditional Chinese Medicine Systems Pharmacology (TCMSP) database four disease databases (Genecards, OMIM, PharmGkb, TTD). An "ingredient-target" interactive map constructed Cytoscape...
Deeper understanding of the crosstalk between host cells and Mycobacterium tuberculosis (Mtb) provides crucial guidelines for rational design novel intervention strategies against (TB). Mycobacteria possess a unique complex cell wall with arabinogalactan (AG) as critical component. AG has been identified virulence factor Mtb which is recognized by galectin-9. Here we demonstrate that galectin-9 directly inhibited mycobacterial growth through AG-binding property carbohydrate-recognition...
Deeper understanding of the crosstalk between host cells and Mycobacterium tuberculosis (Mtb) provides crucial guidelines for rational design novel intervention strategies against (TB). Mycobacteria possess a unique complex cell wall with arabinogalactan (AG) as critical component. AG has been identified virulence factor Mtb which is recognized by galectin-9. Here we demonstrate that galectin-9 directly inhibited mycobacterial growth through AG-binding property carbohydrate-recognition...
Deeper understanding of the crosstalk between host cells and Mycobacterium tuberculosis (Mtb) provides crucial guidelines for rational design novel intervention strategies against (TB). Mycobacteria possess a unique complex cell wall with arabinogalactan (AG) as critical component. AG has been identified virulence factor Mtb which is recognized by galectin-9. Here, we demonstrate that galectin-9 directly inhibited mycobacterial growth through AG-binding property carbohydrate-recognition...
Abstract Deeper understanding of the crosstalk between host cells and Mycobacterium tuberculosis (Mtb) provides crucial guidelines for rational design novel intervention strategies against (TB). Mycobacteria possess a unique complex cell wall with arabinogalactan (AG) as critical component. AG has been identified virulence factor Mtb which is recognized by galectin-9. Here we demonstrate that galectin-9 directly inhibited mycobacterial growth through AG-binding property...
Objective: The study aims to investigate the effect of DEL-1 expression in atherosclerotic plaque formation and its mechanism.Methods: Human left coronary arteries were collected detect expression. ApoE-/- mice used establish atherosclerosis model. artery mouse aorta stained with HE, Oil Red O, Movat staining. levels, chemokines CXC chemokine receptor 4 (CXCR4) ligand stromal cell-derived factor-1alpha (SDF-1α), pathway protein glycogen synthase kinase-3β (GSK-3β), CCAAT enhanced binding β...