A5100440109- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Tropical and Extratropical Cyclones Research
- Coastal and Marine Dynamics
- Tactile and Sensory Interactions
- Infectious Diseases and Tuberculosis
- Ocean Waves and Remote Sensing
- Mechanical Behavior of Composites
- Cancer therapeutics and mechanisms
- Composite Structure Analysis and Optimization
- Indoor and Outdoor Localization Technologies
- Bacteriophages and microbial interactions
- vaccines and immunoinformatics approaches
- Composite Material Mechanics
- Antibiotic Resistance in Bacteria
- Epigenetics and DNA Methylation
- Monoclonal and Polyclonal Antibodies Research
- RNA and protein synthesis mechanisms
- Pneumocystis jirovecii pneumonia detection and treatment
- Advanced Battery Technologies Research
- Advanced Sensor and Energy Harvesting Materials
- Welding Techniques and Residual Stresses
- Advanced oxidation water treatment
- Immune Response and Inflammation
- Environmental remediation with nanomaterials
Shanghai Pulmonary Hospital
2015-2025
Tongji University
2016-2025
Shenzhen University
2023-2024
Peng Cheng Laboratory
2024
State Key Laboratory of Marine Geology
2021
Shanghai Clinical Research Center
2021
Chinese Research Academy of Environmental Sciences
2021
Eye & ENT Hospital of Fudan University
2017
Adaptation to hypoxia is a major challenge for the survival of Mycobacterium tuberculosis (Mtb) in vivo. Interferon (IFN)-γ-producing CD8
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb), and remains a leading public health problem. Previous studies have identified host genetic factors that contribute to Mtb infection outcomes. However, much of the heritability in TB unaccounted for additional susceptibility loci most likely exist. We perform multistage genome-wide association study on 2949 pulmonary patients 5090 healthy controls (833 cases 1220 were genotyped) from Han Chinese population....
Non-tuberculous mycobacterial pulmonary disease (NTM-PD) is a chronic progressive lung that increasing in incidence. Host genetic factors are associated with NTM-PD susceptibility. However, the heritability of not well understood. Here, we perform two-stage genome-wide association study (GWAS) and discover susceptibility locus at 16p21 NTM-PD, especially Mycobacterium avium complex (MAC) disease. As lead variant, rs194800 C allele augments protein kinase beta (PRKCB) gene expression...
Pyrazinamide (PZA) is a first-line antituberculosis (anti-TB) drug capable of killing nonreplicating, persistent Mycobacterium tuberculosis. However, reliable testing the susceptibility M. tuberculosis to PZA challenging. Using 432 clinical isolates, we compared performances five methods for determination PZA: MGIT 960 system, molecular test (mDST), pyrazinamidase (PZase) activity assay, resazurin microtiter assay (REMA), and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)...
Abstract Pathogenic mycobacteria induce the formation of hypoxic granulomas during latent tuberculosis (TB) infection, in which immune system contains, but fails to eliminate mycobacteria. Fatty acid metabolism-related genes are relatively overrepresented mycobacterial genome and favor host-derived fatty acids as nutrient sources. However, whether how modulate host metabolism drive granuloma progression remains unknown. Here, we report that under hypoxia markedly secrete protein...
Silicosis poses a threat to workers' health due the irreversible lung lesions.A retrospective cohort study.A total of 259 patients [80 worked with artificial stone (AS), 179 non-artificial (non-AS)] confirmed silicosis were included in this study. Forty-one AS and 91 non-AS had approximately 2 years' follow-up records [lung function tests high-resolution computer tomography (HRCT)]. Compared first records, increased, densified, or newly emerging lesions HRCT images judged as progression...
The octacoordinate metal carbonyls La(CO)8(+) and Ce(CO)8(+) were observed in laser vaporization of La Ce pure CO gas. peak intensities the mass spectra, infrared photodissociation theoretical calculations indicate that all ligands these two complexes are bonded with central atoms. stretching frequencies determined to be 2110 2108 cm(-1), respectively. Theoretical studies most stable structures for an Oh geometry at its triplet state a slightly distorted quartet state, These represent new...
Oil spills are major threat to marine ecosystem and have long-lasting effect on life water quality. In this study, a two-dimension hydrodynamic oil spill transport model of the Yangtze River Estuary is established based MIKE21 with special attention wind-wave-current interaction (WWCI). The agrees well observed data level, current velocity, real event during Typhoon Fongwong. This study mainly focused particle trajectory spread. results show: (1) when occurs typhoon period, film can rapidly...
Storm surge is one of the most remarkable natural calamities, which shown as abnormal sea level changes in coastal waters during a typhoon event. To investigate responses storm surges to paths, intensities and dynamics, coupled wave–current model used study impacts strong winds, considerable waves complex currents on Yangtze River Estuary (YRE) three representative typhoons Fongwong (2014), Ampil (2018) Lekima (2019) with different paths. The verified using measured data significant wave...
Abstract Background Multidrug-resistant tuberculosis (MDR-TB) is a major public health problem. Early diagnosis of MDR-TB patients essential for minimizing the risk Mycobacterium (MTB) transmission. The conventional drug susceptibility testing (DST) methods detection drug-resistant M.tuberculosis are laborious and cannot provide rapid clinical practice. Methods aim this study was to develop pyrosequencing approach simultaneous resistance rifampin (RIF), isoniazid (INH), ethambutol (EMB),...
Herein, a one-parameter plasticity model proposed by Sun and Chen [Sun CT JL. A simple flow rule for characterizing nonlinear behavior of fiber composites. J Compos Mater 1989; 23: 1009–1020] demonstrates features that make it highly attractive non-linear responses fibrous However, detailed exploitation the model’s potential has been halted unresolved problems include tension–compression asymmetry in stress–strain curves, FEM implementation as well optimal parameters determination, which are...
Early diagnosis and treatment of Mycobacterium tuberculosis infection can prevent most deaths resulting from this pathogen; however, multidrug-resistant strains present serious threats to global control prevention efforts. In study, we identified antigens that could be used for the serodiagnosis drug-resistant M. strains, using a proteomics-based analysis.Serum patients infected with or drug-susceptible healthy controls was subjected two-dimensional gel electrophoresis western blot approach....
Not only has information technology evolved rapidly, but the spatial cognition theory for blind and visually impaired (BVI) people also made great strides, which opened up a new opportunity indoor travel assistance systems (ITASs). However, there are still some issues that have not been effectively addressed due to lack of guidance theory. Thus, this article presents comparative survey among ITASs proposed in last four years an effort inform researchers developers about system problems...
We established an aptamer fluorescence microscopy approach for rapid detection of MTB in clinical sputum samples. The use probes was proven to significantly increase the sensitivity smear microscopy.
Modern inertial measurement units (IMUs) with low cost, small size, and power consumption are the key to improving indoor positioning accuracy. However, performance of IMU in current mobile phones is spotty. The error mainstream cell basically greater than 1%, which makes it difficult for fusion technology achieve accuracy within 3 m on a phone, seriously restricting development industry. Therefore, existing algorithms need introduce additional hardware, such as high-density...
Suspended sediment plays a major role in estuary morphological change and shoal erosion deposition. The impact of storm waves on transport resuspension the Yangtze River Estuary (YRE) was investigated using 3D coupling hydrodynamic-wave model with during Typhoon Ampil. This has been validated field observations water level, current, wave, concentration. run for tide only, + wind, wind wave forcing conditions. It found that: (1) typhoons can increase suspended concentration (SSC) by enhancing...
Abstract Humans recognize and manipulate objects relying on the multidimensional force features captured by tactile sense of skin during manipulation. Since current sensors integrated in robots cannot support to multiple interaction states between manipulator objects, achieving human‐like perception analytical capabilities remains a major challenge for service robots. Prompted involved performing complex tasks, multimodal sensory system is presented provide situ simultaneous sensing when...