A5101523576- Mycobacterium research and diagnosis
- Infectious Diseases and Mycology
- Adipose Tissue and Metabolism
- Advanced Radiotherapy Techniques
- Tuberculosis Research and Epidemiology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Surgical Treatments
- Radiomics and Machine Learning in Medical Imaging
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Endometrial and Cervical Cancer Treatments
- Graphene and Nanomaterials Applications
- Actinomycetales infections and treatment
- Immune cells in cancer
- Head and Neck Cancer Studies
- Peptidase Inhibition and Analysis
- Pancreatic and Hepatic Oncology Research
- Aluminum Alloys Composites Properties
- Colorectal and Anal Carcinomas
- Bone Tissue Engineering Materials
- Lymphatic System and Diseases
- Acupuncture Treatment Research Studies
- Magnesium Alloys: Properties and Applications
- Bone health and osteoporosis research
Central South University
2003-2024
Xiangya Hospital Central South University
2020-2024
Hebei University
2024
Zhengzhou University
2023
Henan Provincial People's Hospital
2023
Shangqiu First People's Hospital
2018-2023
Beihang University
2021-2022
Second Affiliated Hospital of Soochow University
2013-2021
Soochow University
2013-2021
Peking Union Medical College Hospital
2012-2021
Treatment of Mycobacterium abscessus pulmonary infection requires long-term administration multiple antibiotics. Little is known, however, about the impact each antibiotic on treatment outcomes. A retrospective analysis was conducted to evaluate efficacy and adverse effects antibiotics administered in 244 cases M. disease. Only 110 (45.1%) patients met criteria for success. The treating disease continues be unsatisfactory especially infections involving subsp. abscessus. with drug...
Abstract Brown adipose tissue (BAT)-mediated thermogenesis declines with age. However, the underlying mechanism remains unclear. Here we reveal that bone marrow-derived pro-inflammatory and senescent S100A8 + immune cells, mainly T cells neutrophils, invade BAT of male rats mice during aging. These coupled adipocytes sympathetic nerves, compromise axonal networks. Mechanistically, these secrete abundant to inhibit RNA-binding motif protein 3 expression. This downregulation results in...
Abstract The crosstalk between the bone and adipose tissue is known to orchestrate metabolic homeostasis, but underlying mechanisms are largely unknown. Herein, we find that GCA + (grancalcin) immune cells accumulate in marrow release a considerable amount of into circulation during obesity. Genetic deletion Gca myeloid attenuates dysfunction obese male mice, whereas injection recombinant mice causes inflammation insulin resistance. Mechanistically, found binds Prohibitin-2 (PHB2) receptor...
Abstract Skeletal stem/progenitor cell (SSPC) senescence is a major cause of decreased bone regenerative potential with aging, but the causes SSPC remain unclear. In this study, we revealed that macrophages in calluses secrete prosenescent factors, including grancalcin (GCA), during which triggers and impairs fracture healing. Local injection human rGCA young mice induced delayed repair. Genetic deletion Gca monocytes/macrophages was sufficient to rejuvenate repair aged alleviate senescence....
Head and neck cancer (HNC) critically affects patient survival quality of life, highlighting the need for optimized perioperative interventions. While conventional therapies face limitations in specificity toxicity, nanotechnology has emerged as a revolutionary approach. Preoperative application tumor-targeting nanoprobes enables molecular-level lesion identification via biomarker-specific conjugation spatially resolved fluorescence quantification. Intraoperatively, fluorescent nanomaterials...
Statins have been reported to promote bone formation. However, taken orally, their bioavailability is low the bones. Implant therapies require a local repair response, topical application of osteoinductive agents, or biomaterials that implant fixation.The present study evaluated effect single injection simvastatin on screw fixation in an ovariectomized rat model osteoporosis.Dual-energy X-ray absorptiometry, micro-computed tomography, histology, and biomechanical tests revealed 5 10 mg...
Chemotherapeutic options against Mycobacterium abscessus infections are very limited. Bedaquiline, a new antituberculosis (anti-TB) drug, is effective for the treatment of multidrug-resistant TB. However, few data available on bedaquiline M. infections. In this study, we determined profile in vitro susceptibility clinical isolates to and investigated potential molecular mechanisms decreased susceptibility. A total 197 were collected from sputum bronchoalveolar fluid patients with lung...
Objectives: To investigate the psychological status of patients with sleep apnea-hypopnea syndrome (SAHS) and to evaluate association SAHS symptoms, using Symptom Checklist-90 (SCL-90) scale. Methods: The study comprised 30 (25 men, 5 women) matched, healthy control subjects. They all completed SCL-90 Epworth Sleep Scale (ESS) underwent a whole-night polysomnographic (PSG) examination. We used t-tests for group comparisons nocturnal PSG characteristics, daytime sleepiness, symptoms. employed...
A total of 194 Mycobacterium abscessus isolates were collected from patients, and the whole genomes sequenced. Eighty-five (43.8%) showed linezolid (LZD) resistance. Only 8.2% resistant harbored 23S rRNA mutations. Quantitative real-time PCR (qRT-PCR) revealed higher transcriptional levels efflux pumps lmrS mmpL9 in LZD-resistant isolates. Genome comparative analysis identified several new LZD resistance-associated genes. This study highlights role M. proposes potential target genes for...
Mycobacterium abscessus accounts for a large proportion of lung disease cases caused by rapidly growing mycobacteria. The association between clarithromycin sensitivity and treatment outcome is clear. However, M. culture antibiotic susceptibility testing are time-consuming. Clarithromycin genotyping offers an alternate, rapid approach to predicting the efficacy clarithromycin-based therapy. patients were divided into two groups based upon genotype organism isolated. A retrospective analysis...
The pancreatic immune-related adverse event (irAE) is a rare but increasingly occurrence disease with limited knowledge, which was associated the use of immune checkpoint inhibitors (ICIs).In this case series study irAE patients, clinical and radiological manifestations are summarized. Baseline post-treatment fecal microbiota acute pancreatitis (irAP) patients were analyzed by 16 s rDNA amplicon sequencing method.A total six enrolled into study, onset irAEs occurred median 105 days after 4.5...
Abstract Background Multidrug-resistant tuberculosis (MDR-TB) is a major public health problem. Early diagnosis of MDR-TB patients essential for minimizing the risk Mycobacterium (MTB) transmission. The conventional drug susceptibility testing (DST) methods detection drug-resistant M.tuberculosis are laborious and cannot provide rapid clinical practice. Methods aim this study was to develop pyrosequencing approach simultaneous resistance rifampin (RIF), isoniazid (INH), ethambutol (EMB),...
Obesity is characterized by the expansion of adipose tissue which partially modulated adipogenesis. In present study, we identified five differentially expressed genes incorporating two adipogenesis-related datasets from GEO database and their correlation with adipogenic markers. However, role scavenger receptor class A member 3 (SCARA3) in obesity-related disorders has been rarely reported. We found that Scara3 expression old tissue-derived mesenchymal stem cells (Ad-MSCs) was lower than it...
Non-alcoholic fatty liver disease (NAFLD), hallmarked by steatosis, is becoming a global concern, but effective and safe drugs for NAFLD are still lacking at present. Parathyroid hormone (PTH), the only FDA-approved anabolic treatment osteoporosis, important in calcium-phosphate homeostasis. However, little known about its potential therapeutic effects on other diseases. Here, we report that intermittent administration of PTH ameliorated non-alcoholic steatosis diet-induced obese (DIO) mice...
Mycobacterium tuberculosis and nontuberculous mycobacterium (NTM) infections often exhibit similar clinical symptoms. Timely effective treatment relies on the rapid accurate identification of species resistance genotypes.
Clarithromycin resistance is increasing dramatically among Mycobacterium abscessus complex. The main mechanisms are mutations in the erm(41) and rrl genes. Here we report PCR-based denaturing gradient gel electrophoresis (DGGE) as an alternative method for rapidly detection of M. isolates. Four primer sets targeting full-length gene a 354bp fragment were designed. A combination 16 different DGGE patterns observed gene, including subsp. 1 massiliense. Six obtained gene. Mutations detected by...