A5100416802- Tuberculosis Research and Epidemiology
- Membrane Separation Technologies
- Sleep and Wakefulness Research
- Sleep and related disorders
- Membrane-based Ion Separation Techniques
- Hormonal Regulation and Hypertension
- Immune Cell Function and Interaction
- Fatty Acid Research and Health
- Mesenchymal stem cell research
- Diagnosis and treatment of tuberculosis
- Graphene and Nanomaterials Applications
- Atherosclerosis and Cardiovascular Diseases
- Systemic Lupus Erythematosus Research
- Infectious Diseases and Tuberculosis
- Periodontal Regeneration and Treatments
- Pharmacological Effects of Natural Compounds
- Sepsis Diagnosis and Treatment
- Axon Guidance and Neuronal Signaling
- Gout, Hyperuricemia, Uric Acid
- Nanomaterials for catalytic reactions
- Selenium in Biological Systems
- Renal Diseases and Glomerulopathies
- Mechanical Failure Analysis and Simulation
- Herpesvirus Infections and Treatments
- Biomarkers in Disease Mechanisms
Tianjin Medical University General Hospital
2019-2025
Chengdu University of Information Technology
2025
Ningxia Meteorological Bureau
2025
KU Leuven
2021-2023
Tsinghua University
2023
Brigham and Women's Hospital
2023
Sichuan University
2022
Peking University
2021-2022
Peking University Third Hospital
2022
Yantaishan Hospital
2022
The favorable terroir of China's northwest region provides an ideal environment for the cultivation and thriving growth grapes. However, climate change threatens to alter optimal grape-growing regions, presenting considerable challenges local wine making industry. To enhance utilization regional resources refine grape industry's spatial distribution, this study assessed performance nine models from Coupled Model Intercomparison Project Phase 6 (CMIP6) in Northwestern China, simulated future...
Smartphone applications are widely used for self-help interventions in adult cancer survivors. However, parents of pediatric patients limited. We developed an to assist children with acute lymphoblastic leukemia. The aim this study is evaluate the app's usability and effectiveness a preliminary way. A stepwise approach mixed methods were used. application was initially tested by healthcare providers, their comments suggestions develop updated version. This version Comments nonverbal...
The objective of this study was to evaluate the change ratio monocytes lymphocytes in patients with active tuberculosis, such as provide reference for clinical diagnosis and treatment.All data were collected from database Fifth People's Hospital Taiyuan, China. A total 151 who had newly diagnosed tuberculosis therapy hospital 129 healthy controls selected.Median 0.45 (IQR: 0.28-0.67) before treatment 0.32 0.25-0.46) on discharge (P < 0.001).Ratio may be applied chemotherapeutic efficacy tuberculosis.
Stem cells from human exfoliated deciduous teeth (SHED) can be used as a potential clinical material. But the use of xenogeneic ingredients will increase risk zoonotic disease transmission. Human platelet lysate (HPL) is surrogate and in cell expansion with reliability applications. In this study, we synthesized chitosan/gelatin/gellan gum hydrogel supplemented HPL investigated effect 3D culture for SHED. TMT-tagged proteomics was to decipher secretome protein profiles SHEDs total 3209...
Early diagnosis and treatment of Mycobacterium tuberculosis infection can prevent most deaths resulting from this pathogen; however, multidrug-resistant strains present serious threats to global control prevention efforts. In study, we identified antigens that could be used for the serodiagnosis drug-resistant M. strains, using a proteomics-based analysis.Serum patients infected with or drug-susceptible healthy controls was subjected two-dimensional gel electrophoresis western blot approach....
In this work atomic force microscopy (AFM) was applied to study the wettability of mica and graphite modified with surfactant dodecyltrimethylammonium bromide (DTAB) at varying DTAB concentrations (below cmc) adsorption time. The coverage states on surfaces were analyzed from AFM images, while contact angle measurement made for DTAB-modified surfaces. experimental results have shown that aggregates formed as needle-like dots covering surface concentration 10−6–10−4 mol/L. increased...
In the chicken model of Pb and Se, Se alleviated Pb-induced changes inflammatory factors, selenoproteins, histology. injury through inhibiting NF-κB signaling pathway stimulating selenoproteins in hearts.
Dihydroartemisinin (DHA) is a semisynthetic derivative of artemisinin, which has been found to exhibit broad range biological activities, excluding antimalarial effects; however its effects on the gut microbiota remain poorly understood. The present study aimed investigate DHA microbiome in mice and determine potential pharmaceutical activities through alteration microbiota. Serum glucose, triglyceride (TG), total cholesterol, lipopolysaccharide, high density lipoprotein‑cholesterol, low...
Abstract Objectives To assess the correlation of cognitive function with sleep stability and depressive‐anxious symptoms in insomnia patients. Methods Twenty‐two patients impairment (insomnia‐CI), 21 normal cognition (insomnia‐CN), 15 matched healthy control subjects (HCs) were enrolled completed neuropsychological tests, Hamilton Depression Anxiety Scales (HAMD HAMA), Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index (PSQI),the Insomnia Severity (ISI), cardiopulmonary coupling (CPC)...
Plexins are semaphorin receptors that play essential roles in mammalian neuronal axon guidance and many other important biological processes. Plexin signaling depends on a semaphorin-induced dimerization mechanism is modulated by small GTPases of the Rho family, which RND1 serves as plexin activator yet its close homolog RhoD an inhibitor. Using molecular dynamics (MD) simulations, we showed reinforces interface, whereas destabilizes it due to their differential interaction with cell...
High serum uric acid (SUA) levels increase the risk of overall cancer morbidity and mortality, particularly for digestive malignancies. Nevertheless, correlation between SUA level clinical outcomes postoperative patients with colorectal (CRC) treated by chemotherapy is unclear. This study aimed at exploring relationship baseline progression-free survival (PFS), disease control rate (DCR), safety in CRC receiving chemotherapy. We conducted a retrospective to evaluate PFS, DCR, incidence...
目的建立HPLC-MS/MS法同时测定紫菀中山柰酚、槲皮素、木犀草素、异鼠李素、东莨菪内酯、伞形花内酯、阿魏酸、咖啡酸和绿原酸9种化学成分的方法。 方法采用Diamonsil C18柱（150 mm×4.6 mm，5μm），流动相为水（0.05%甲酸）-乙腈（0.05%甲酸），梯度洗脱，体积流量0.8 mL/min，进样量10μL，柱温30℃；采用电喷雾离子源进行负离子模式监测，多反应监测模式（MRM）用于定量分析，源喷射电压为-4 500 V，离子源温度为650℃。 结果山柰酚、槲皮素、木犀草素、异鼠李素、东莨菪内酯、伞形花内酯、阿魏酸、咖啡酸和绿原酸分别在0.970~30.30μg/mL（r＝0.998 7）、0.498~15.55μg/mL（r＝0.999 6）、0.014~0.438μg/mL（r＝0.999 5）、0.022~21.95μg/mL（r＝0.998 5）、0.011~1.100μg/mL（r＝0.999 5）、0.008~0.247μg/mL（r＝0.999 8）、0.194~6.050μg/mL（r＝0.999...
Dental stem cells isolated from oral tissues have been shown to provide with high proliferation ability and multilineage differentiation potential. Gingival mesenchymal (GMSCs) periodontal ligament (PDLSCs), kinds of dental cells, can be used as substitutes for tissue repair materials because their similar regenerative functions. In this study, we aim explore the similarities differences between protein profiles GMSCs PDLSCs through quantitative proteomics. A total 2821 proteins were...
The role of cystic fibrosis transmembrane conductance regulator (CFTR) in hematopoiesis and adult leukemia has been demonstrated using a zebrafish model cell lines our previous works. Here, we continue to explore the association between CFTR human childhood B-cell acute lymphoblastic (B-ALL).We continued collect peripheral blood bone marrows patients diagnosed with primary B-ALL as well non-leukemia controls isolated lymphocytes for analysis western blotting quantitative real-time polymerase...
Objective To investigate metabolite changes in the brain of patients with nondementia vascular cognitive impairment (VCIND) and mild (MCI) using magnetic resonance spectroscopy (MRS). Methods Twenty-five VCIND,21 ones MCI 30 normal controls (NC) were participated this experiment.The absolute concentrations N-acetyl aspartate (NAA),choline (Cho),myo-inositol (MI),creatine (Cr) ratios NAA/Cr,Cho/Cr,MI/Cr,NAA/MI NAA/Cho measured bilaterally posterior cingulate gyrus (PCG),white matter...
Background: The effect of omega-3 (n-3) treatment on cardiovascular disease (CVD) outcomes in randomized controlled trials remains inconsistent. We hypothesize that the downstream products n-3 metabolism, including bioactive lipids (BALs), have a heterogeneous relationship with CVD, which may provide insight into response heterogeneity. Methods: Using state art LC-MS, we assayed plasma lipidome (>10K BALs) across 3,512 individuals at baseline and Y1 or -2, VITAL substudies (CVD case...