A5020568082- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Immune cells in cancer
- Nanoplatforms for cancer theranostics
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Biosensors and Analytical Detection
- Immune Response and Inflammation
- Ferroptosis and cancer prognosis
- Sepsis Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Prenatal Screening and Diagnostics
- Advanced Thermoelectric Materials and Devices
- Nanoparticle-Based Drug Delivery
- Kruppel-like factors research
- Mesenchymal stem cell research
- Advanced biosensing and bioanalysis techniques
- Protein Hydrolysis and Bioactive Peptides
- Advanced Glycation End Products research
- Periodontal Regeneration and Treatments
Lanzhou University
2023-2025
First Affiliated Hospital of Gannan Medical University
2015-2024
Gannan Medical University
2019-2024
East China University of Science and Technology
2022-2024
Kunming University of Science and Technology
2024
Tianjin University of Science and Technology
2023-2024
Henan University
2024
Henan Academy of Sciences
2024
Huadong Hospital
2024
Fudan University
2024
DNA methylation is essential for mammalian development and physiology. Here we report that the developmentally regulated H19 lncRNA binds to inhibits S-adenosylhomocysteine hydrolase (SAHH), only enzyme capable of hydrolysing (SAH). SAH a potent feedback inhibitor S-adenosylmethionine (SAM)-dependent methyltransferases methylate diverse cellular components, including DNA, RNA, proteins, lipids neurotransmitters. We show knockdown activates SAHH, leading increased DNMT3B-mediated an...
Circulating tumor cells (CTCs), circulating DNA (ctDNA), and extracellular vehicles (EVs) have received significant attention in recent times as emerging biomarkers subjects of transformational studies. The three main branches liquid biopsy evolved from the primary detection targets—CTC, ctDNA, EVs—each with distinct benefits. CTCs are derived cancer original or metastases may display global features tumor. ctDNA has been extensively analyzed used to aid diagnosis, treatment, prognosis...
The molecular mechanisms underlying the antineoplastic properties of metformin, a first-line drug for type 2 diabetes, remain elusive. Here we report that metformin induces genome-wide alterations in DNA methylation by modulating activity S-adenosylhomocysteine hydrolase (SAHH). Exposing cancer cells to leads hypermethylation tumor-promoting pathway genes and concomitant inhibition cell proliferation. Metformin acts upregulating microRNA let-7 through AMPK activation, leading degradation H19...
Periodontitis is an inflammatory disease worldwide that may result in periodontal defect (especially alveolar bone defect) and even tooth loss. Stem-cell-based approach combined with injectable hydrogels has been proposed as a promising strategy treatments. Stem cells fate closely depends on their extracellular matrix (ECM) characteristics. Hence, it necessary to engineer appropriate hydrogel deliver stem into the while serving ECM during healing. Therefore, cell-ECM interaction should be...
Initiation of flowering, also called heading, in rice (Oryza sativa) is determined by the florigens encoded Heading date 3a (Hd3a) and RICE FLOWERING LOCUS T1 (RFT1). Early heading 1 (Ehd1) regulates Hd3a RFT1. However, different varieties have diverged alleles Ehd1 Hd3a/RFT1 their genetic interactions remain largely unclear. Here we generated three segregating populations for combinations alleles, analyzed between these alleles. We demonstrated that, an ehd1 mutant background, was silenced,...
Abstract Background Sepsis involves life-threatening organ dysfunction and is caused by a dysregulated host response to infection. No specific therapies against sepsis have been reported. Celastrol (Cel) natural anti-inflammatory compound that shows potential systemic inflammatory diseases. This study aimed investigate the pharmacological activity molecular mechanism of Cel in models endotoxemia sepsis. Methods We evaluated efficacy mice macrophage cultures treated with lipopolysaccharide...
Abstract Immune checkpoint blockade (ICB) therapy is an emerging strategy for cancer immunotherapy; however, the actual effects of ICB are greatly limited by immunosuppressive tumor microenvironment (TME, i.e., “cold” tumors). Although engineered nanomaterials display significant importance to regulate TME in treatment, most them focus on “immunosilent” apoptotic processes that cannot elicit sufficient immune responses further immunotherapy. Herein, a GSH‐responsive nanomodulator reported...
With the escalating global antimicrobial resistance crisis, there is an urgent need for innovative strategies against drug-resistant microbes. Accumulating evidence indicates microbial extracellular vesicles (EVs) contribute to resistance. Therefore, comprehensively elucidating roles and mechanisms of EVs in conferring could provide new perspectives avenues novel approaches. In this review, we systematically examine current research on involving bacterial, fungal, parasitic EVs, delineating...
Background The emerging Coronavirus Disease-2019 (COVID-19) has challenged the public health globally. With increasing requirement of detection for SARS-CoV-2 outside laboratory setting, a rapid and precise Point Care Test (POCT) is urgently needed. Methods Targeting nucleocapsid (N) gene SARS-CoV-2, specific primers, probes reverse transcription recombinase-aided amplification coupled with lateral flow dipstick (RT-RAA/LFD) platform were designed. For specificity evaluation, it was tested...
Abstract Cancer, a prevalent and complex disease, presents significant challenge to the medical community. It is characterized by irregular cell differentiation, excessive proliferation, uncontrolled growth, invasion of nearby tissues, spread distant organs. Its progression involves interplay several elements processes. Extracellular vesicles (EVs) serve as critical intermediaries in intercellular communication, transporting molecules such lipids, RNA, membrane, cytoplasmic proteins between...
Glycyrrhetinic acid (GA) shows great efficiency against non-small cell lung cancer (NSCLC), but the detailed mechanism is unclear, which has limited its clinical application. Herein, we investigated potential targets of GA NSCLC by activity-based protein profiling (ABPP) technology and combination histopathology proteomics validation. In vitro in vivo results indicated significantly inhibited via promotion peroxiredoxin-6 (Prdx6) caspase-3 (Casp3)-mediated mitochondrial apoptosis. This...
Extracellular vesicles (EVs) are important cell-to-cell communication mediators. This paper focuses on the regulatory role of tumor-derived EVs macrophages. It aims to investigate causes tumor progression and therapeutic directions. Tumor-derived can cause macrophages shift M1 or M2 phenotypes. indicates they alter M1/M2 cell ratio have pro-tumor anti-inflammatory effects. discusses several key points: first, factors that stimulate macrophage polarization cytokines released as a result;...
Globally, millions of individuals are impacted by neurodegenerative disorders including Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), Parkinson's (PD), and Alzheimer's (AD). Although a great deal energy financial resources have been invested in disease-related research, breakthroughs therapeutic approaches remain elusive. The breakdown cells usually happens together with the onset diseases. However, mechanism that triggers neuronal loss is unknown. Lipid peroxidation, which...
Two-dimensional (2D) van der Waals magnetic materials that host skyrmions are promising candidates for the next-generation memory devices. Here, we have predicted a class of 2D chromium-based monolayer ferromagnetic semiconducting with Curie temperature (Tc) exceeding 320 K. We systematically studied their ferromagnetism and quantum transport properties by employing combination density functional calculations, Monte Carlo simulations, atomic spin dynamics non-equilibrium Green function...
Abstract Background Colorectal cancer (CRC) commonly exhibits tolerance to cisplatin treatment, but the underlying mechanisms remain unclear. Within tumor microenvironment, macrophages play a role in resisting cytotoxic effects of chemotherapy by engaging efferocytosis clear apoptotic cells induced chemotherapeutic agents. The involvement extracellular vesicles (EVs), an intercellular communicator within regulating for promotion drug resistance has not been thoroughly investigated. Methods...
Abstract Background Climate change associated with droughts has led to widespread forest decline. Hydraulic and carbon-related performances are key physiological processes for the tolerance of trees environmental changes, yet our current understanding such decline is still limited. Here, we investigated hydraulic carbohydrate healthy declining (canopy dieback) in temperate larch ( Larix principis-rupprechtii ) plantations. Results Relative trees, higher native percentage loss xylem...