A5049845417- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Cancer Research and Treatments
- Advanced Nanomaterials in Catalysis
- Angiogenesis and VEGF in Cancer
- Natural product bioactivities and synthesis
- Cancer, Hypoxia, and Metabolism
- RNA Interference and Gene Delivery
- Advanced Drug Delivery Systems
- Virus-based gene therapy research
- Coronary Interventions and Diagnostics
- Luminescence and Fluorescent Materials
- Immune cells in cancer
- Drug Transport and Resistance Mechanisms
- Immunotherapy and Immune Responses
- Ginseng Biological Effects and Applications
- Advancements in Transdermal Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Monoclonal and Polyclonal Antibodies Research
- Cerebrovascular and Carotid Artery Diseases
- Drug Solubulity and Delivery Systems
- Bone Metabolism and Diseases
- Analytical Chemistry and Chromatography
- Natural Compounds in Disease Treatment
- Sulfur Compounds in Biology
Shanghai Jiao Tong University
2016-2025
Zunyi Medical University
2022-2025
Tongren Hospital
2016-2025
Nanchang University
2018-2025
State Key Laboratory of Pollution Control and Resource Reuse
2024-2025
Tongji University
2024-2025
Shanghai Institute of Pollution Control and Ecological Security
2024-2025
Xiamen University
2025
Zhejiang University
2016-2024
Northwest University
2023-2024
Abstract Chemodynamic therapy (CDT), enabling selective therapeutic effects and low side effect, attracts increasing attention in recent years. However, limited intracellular content of H 2 O acid at the tumor site restrains lasting Fenton reaction thus anticancer efficacy CDT. Herein, a nanoscale Co–ferrocene metal–organic framework (Co‐Fc NMOF) with high activity is synthesized combined glucose oxidase (GOx) to construct cascade enzymatic/Fenton catalytic platform (Co‐Fc@GOx) for enhanced...
Delivery of therapeutics into the solid tumor microenvironment is a major challenge for cancer nanomedicine. Administration certain exogenous enzymes which deplete stromal components has been proposed as method to improve drug delivery. Here we present protein-free collagen depletion strategy delivery tumors, based on activating endogenous matrix metalloproteinases (MMP-1 and -2) using nitric oxide (NO). Mesoporous silica nanoparticles (MSN) were loaded with chemotherapeutic agent,...
Photodynamic therapy (PDT) of cancer is limited by tumor hypoxia. Platinum nanoparticles (nano-Pt) as a catalase-like nanoenzyme can enhance PDT through catalytic oxygen supply. However, the cytotoxic activity nano-Pt not comprehensively considered in existing methods to exert their multifunctional antitumor effects. Here, are loaded into liposomes via reverse phase evaporation. The clinical photosensitizer verteporfin (VP) lipid bilayer confer activity. Murine macrophage cell membranes...
The conversion of endogenous H2 O2 into toxic hydroxyl radical (• OH) via catalytic nanoparticles is explored for tumor therapy and received considerable success. intrinsic characteristics microenvironment in cells, such as limited overexpressed glutathione (GSH), hinder the intracellular • OH accumulation thus weaken therapeutic efficacy considerably. In this study, fine CaO2 with Cu-ferrocene molecules at surface (CaO2 /Cu-ferrocene) are successfully designed synthesized. Under an acidic...
Glucose-oxidase (GOx)-mediated starvation by consuming intracellular glucose has aroused extensive exploration as an advanced approach for tumor treatment. However, this reaction of catalytic oxidation GOx is highly dependent on the on-site oxygen content, and thus therapy often suffers unexpected anticancer outcomes due to intrinsic tumorous hypoxia. Herein, porous platinum nanospheres (pPts), incorporated with molecules (PtGs), are synthesized enable synergistic cancer therapy. In system,...
Metal–organic frameworks (MOFs) have been identified as promising materials for the delivery of therapeutics to cure cancer owing their intrinsic porous structure. However, in a majority cases, MOFs act only cargo anticancer drugs while little attention has focused on utilization intriguing physical and chemical properties potential purposes. Herein first time, an ultrathin (16.4 nm thick) ferrocene-based MOF (Zr-Fc MOF) nanosheet synthesized synergistic photothermal therapy (PTT) Fenton...
Liposomal drug delivery for cancer therapy can be limited due to leakage in circulation. Here, we develop a new method enhance the stability of actively loaded liposomal doxorubicin (DOX) through embedding stiff nanobowl water cavity. Nanobowl-supported DOX (DOX@NbLipo) resists influence plasma protein and blood flow shear force prevent leakage. This approach yields improved tumor sites enhanced antitumor efficacy. Compared alternative methods modifying liposome surface composition...
Abnormal tumor microenvironment, such as hypoxia, interstitial hypertension and low pH, leads to unexpected resistance for current treatment.The development of versatile drug delivery systems which present responsive characteristics microenvironment (TME) has been extensively carried out, but remains challenging.In this study, zeolitic imidazolate framework-8 (ZIF-8) coated ZnS nanoparticles have designed prepared co-delivery ICG/TPZ molecules, denoted ZSZIT, H2S-amplified synergistic...
The actin-bundling protein L-plastin (LPL) mediates the resorption activity of osteoclasts, but its therapeutic potential in pathological bone loss remains unexplored. Here, we report that LPL knockout mice show increased mass and cortical thickness with more mononuclear tartrate-resistant acid phosphatase-positive cells, osteoblasts, CD31hiEmcnhi endothelial vessels, fewer multinuclear osteoclasts marrow periosteum. deletion impeded preosteoclasts fusion by inhibiting filopodia formation...
In view of the multiple pathological hallmarks tumors, nanosystems for sequential delivery various drugs whose targets are separately located inside and outside tumor cells desired improved cancer therapy. However, current is mainly achieved through enzyme- or acid-dependent degradation nanocarrier, which would be influenced by heterogeneous microenvironment, unloading efficiency drug acting on target usually unsatisfactory. Here, a light-triggered strategy based liposomal formulation...
Abstract Living cell‐based drug delivery systems (LC‐DDSs) are limited by adverse interactions between drugs and carrier cells, typically drug‐induced toxicity to cells restriction of on release. Here, a method is established adsorb nanocarriers externally living thereby reducing cytotoxicity caused uptake realizing improved release at the disease site. It found that divalent metal ion‐phenolic network (MPN) affords adhesion poly (lactic‐co‐glycolic acid) nanoparticles onto macrophage (Mφ)...
Doxorubicin (Dox)-loaded stealth liposomes (similar to those in clinical use) can incorporate small amounts of porphyrin–phospholipid (PoP) enable chemophototherapy (CPT). PoP is also an intrinsic and intrabilayer 64Cu chelator, although how radiolabeling impacts drug delivery has not yet been assessed. Here, we show that radiolabel the stable bilayer preformed Dox-loaded with inclusion 1% ethanol without inducing leakage. Dox-PoP labeled copper behaved nearly identically unlabeled ones...
Abstract PUMILIO (PUM) proteins belong to the highly conserved PUF family post-transcriptional regulators involved in diverse biological processes. However, their function carcinogenesis remains under-explored. Here, we report that Pum1 and Pum2 display increased expression human colorectal cancer (CRC). Intestine-specific knockout of mice significantly inhibits progression colitis-associated AOM/DSS model. Knockout or knockdown and/or CRC cells result a significant decrease tumorigenicity...
Intrinsic characteristics of microorganisms, including non-specific metabolism sites, toxic byproducts, and uncontrolled proliferation constrain their exploitation in medical applications such as tumor therapy. Here, the authors report an engineered biohybrid that can efficiently target cancerous sites through a pre-determined metabolic pathway to enable precise ablation. In this system, DH5α Escherichia coli is by introduction hypoxia-inducible promoters lactate oxidase genes, further...
The unique bioenergetic feature of cancer, aerobic glycolysis or the Warburg effect, is an attractive therapeutic target for cancer therapy. Reversing glycolytic phenotype may trigger apoptosis in tumor cells. Recently, dichloroacetate (DCA) was proven to produce significant cytotoxic effects certain cells through this distinct mechanism. In study, effect DCA on metabolism cervical HeLa explored and its synergistic growth inhibition with cisplatin also evaluated. intracellular changes...