A5091841056- Nanoplatforms for cancer theranostics
- Luminescence Properties of Advanced Materials
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- Electrospun Nanofibers in Biomedical Applications
- Luminescence and Fluorescent Materials
- Bone Tissue Engineering Materials
- Advanced Photocatalysis Techniques
- Cancer Research and Treatments
- Layered Double Hydroxides Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- Neurotransmitter Receptor Influence on Behavior
- Graphene and Nanomaterials Applications
- Neuroscience and Neuropharmacology Research
- Photodynamic Therapy Research Studies
- RNA Interference and Gene Delivery
- Memory and Neural Mechanisms
- 3D Printing in Biomedical Research
- Nicotinic Acetylcholine Receptors Study
- Ion channel regulation and function
- Protist diversity and phylogeny
- Amyloidosis: Diagnosis, Treatment, Outcomes
- High-Velocity Impact and Material Behavior
- Fluid Dynamics Simulations and Interactions
- MXene and MAX Phase Materials
Zhejiang University of Science and Technology
2023-2025
Zhejiang University
2015-2025
University of Tennessee Medical Center
2020
University of Tennessee at Knoxville
2020
Hangzhou Xixi hospital
2020
Hangzhou Academy of Agricultural Sciences
2014-2018
State Council of the People's Republic of China
2018
Hunan University
2013
University of Tennessee Health Science Center
2000-2003
Chinese Preventive Medicine Association
1995
Intrinsic characteristics of microorganisms, including non-specific metabolism sites, toxic byproducts, and uncontrolled proliferation constrain their exploitation in medical applications such as tumor therapy. Here, the authors report an engineered biohybrid that can efficiently target cancerous sites through a pre-determined metabolic pathway to enable precise ablation. In this system, DH5α Escherichia coli is by introduction hypoxia-inducible promoters lactate oxidase genes, further...
Orexins are two recently discovered neuropeptides that can stimulate food intake. As the chronic use of tobacco typically leads to a reduction in body weight, it is interest determine whether nicotine, major biologically active ingredient, has an effect on orexin metabolism brain. Using semiquantitative RT-PCR technique, levels messenger RNA (mRNA) for prepro-orexin, A (OX1-R) and B (OX2-R) receptors were 20–50% higher rats receiving nicotine 14 days at level 2–4 mg/kg·day compared with...
Implantable localized drug delivery systems (LDDSs) with intelligent functionalities have emerged as a powerful chemotherapeutic platform in curing cancer. Developing LDDSs rationally controlled release and real-time monitoring holds promise for personalized therapeutic protocols but suffers daunting challenges. To overcome such challenges, series of porous Yb3+/Er3+ codoped CaTiO3 (CTO:Yb,Er) nanofibers, specifically designed surface functionalization, were synthesized doxorubicin (DOX)...
Tumor microbiomes are increasingly associated with the growth and metastasis of tumors. Exploring regulation tumor microbiome through therapeutics is an area interest in cancer therapy. In this study, authors have investigated a biohybrid 1550 nm light-excited photosynthetic ability to regulate microbiome. This system utilizes Er-based core–shell upconversion nanoparticles arm microalga Chlorella, enabling rapid evolution Chlorella perform oxygenic photosynthesis under light excitation. may...
We have fabricated a flexible membrane, consisting of SiO2 nanofibres armoured with upconversion nanoparticles, exhibiting intense photoluminescence. These assemblies were subsequently grafted molecular beacons to produce biosensor suitable for the detection specific microRNA and applications in early cancer point-of-care diagnosis.
Sonodynamic therapy (SDT), presenting spatial and temporal control of ROS generation triggered by ultrasound field, has attracted considerable attention in tumor treatment. However, its therapeutic efficacy is severely hindered the intrinsic hypoxia solid lack smart design material band structure. Here study, fine α-Fe2O3 nanoparticles armored with Pt nanocrystals (α-Fe2O3@Pt) was investigated as an alternative SDT agent ingenious bandgap structural design. The Schottky barrier, due to...
As a result of their radiation-free nature and deep-penetration ability, tumor theranostics mediated by ultrasound have become increasingly recognized as modality with high potential for translation into clinical cancer treatment. The effective integration imaging sonodynamic therapy (SDT) one nanoplatform remains an enormous challenge yet to be fully resolved. Here, novel theranostic system, consisting rattle-type SiO2 (r-SiO2) loaded Mn-doped In2S3/InOOH (SMISO), was designed synthesized...
CaTiO<sub>3</sub>:Yb,Er nanofibers, co-conjugated with Rose Bengal and gold nanorods, enable a synergistic photodynamic/photothermal phenomenon for superior cancer cell killing effect.
HFe-TA nanoparticles, with a fine hollow microstructure, are synthesized and incorporated ICG for synergistic photo/chemodynamic therapy enhanced efficacy.
Treatments of osteolytic lesions due to malignant metastasis remain one the major clinical challenges. The residual tumor cells after surgical resections and an acidic microenvironment are unfavorable for osteogenic induction. Bortezomib (BTZ), a proteasome inhibitor used in chemotherapy, also has potential concentration- Ca2+-dependent manners. In this study, controlled delivery BTZ novel bifunctional scaffold based on nano-hydroxyapatite (nHA) sodium alginate (SA) nanocomposite, namely...
A FRET biosensor, based on rare earth-doped calcium fluoride particles incorporated into silica nanofibers (CaF<sub>2</sub>:Yb,Ho@SiO<sub>2</sub>) and gold nanoparticles (AuNPs), offers a simple quantitative methodology for miRNA-195 detection.
Implantable localized drug delivery systems (LDDSs) have been intensively investigated for cancer therapy. However, the anticancer agent release behavior as well local therapeutic process in complex physiological environment remains a dark zone and consequently hinders their clinical applications. Herein, series of Er3+-doped electrospun strontium titanate (SrTiO3, STO) nanofibers with refined microstructural characteristics were exploited carrier doxorubicin (DOX) due to its...
Nanoparticles, presenting catalytic activity to induce intracellular oxidative species, have been extensively explored for tumor treatment, but suffer daunting challenges in the limited H2O2 and thus suppressed therapeutic efficacy. Here this study, a type of composite nanoparticles, consisting CaO2 core Co-ferrocene shell, is designed synthesized combinational treatment. The findings indicate that can be hydrolyzed produce large amounts calcium ions at acidic sites. Meanwhile, shell acts as...
The design of multifunctional localized drug delivery systems (LDDSs) has been endeavored in the past decades worldwide. matrix material LDDSs is known as a crucial factor for success its transformation from laboratory to clinical practices. Herein, biocompatible ceramic, strontium titanate (SrTiO3, STO), was utilized matrix. A variety fine Er doped SrTiO3 (STO:Er) nanofibers were fabricated via electrospinning. After surface functionalization with amino groups, loading capacity STO:Er...
Abstract Developing novel substances to synergize with nanozymes is a challenging yet indispensable task enable the nanozyme‐based therapeutics tackle individual variations in tumor physicochemical properties. The advancement of machine learning (ML) has provided useful tool enhance accuracy and efficiency developing synergistic substances. In this study, ML models mine low‐cytotoxicity oncolytic peptides are applied. filtering Pipeline constructed using traversal design Autogluon framework....
CaCO 3 -mineralized cobalt-based nanocatalysts were synthesized and loaded with curcumin for synergistic nanocatalytic therapy/chemotherapy combined calcium overload. Curcumin acts as a ligand an electron donor to enhance the efficacy of therapy.
Spectral tunable Er doped PZT nanofibers are fabricated by controlling crystallization and doping conditions using electrospinning for electro-mechano-optical microdevices.