A5101133932- Biofuel production and bioconversion
- RNA Interference and Gene Delivery
- Catalysis for Biomass Conversion
- Anaerobic Digestion and Biogas Production
- Viral Infectious Diseases and Gene Expression in Insects
- Neurobiology and Insect Physiology Research
- Phytochemical Studies and Bioactivities
- Ferroptosis and cancer prognosis
- Biochemical and Molecular Research
- Extracellular vesicles in disease
- RNA and protein synthesis mechanisms
- Immune Cell Function and Interaction
- Immune cells in cancer
- Microbial Metabolic Engineering and Bioproduction
- Enzyme-mediated dye degradation
- Photosynthetic Processes and Mechanisms
- Polysaccharides and Plant Cell Walls
- Meat and Animal Product Quality
- Protein Hydrolysis and Bioactive Peptides
- Cancer-related molecular mechanisms research
- Sirtuins and Resveratrol in Medicine
- Acute Myeloid Leukemia Research
- Pancreatic and Hepatic Oncology Research
- Lipid Membrane Structure and Behavior
- Microbial Metabolism and Applications
City University of Hong Kong
2025
University of Electronic Science and Technology of China
2020-2025
Tianjin Medical University General Hospital
2020-2024
Nanjing Agricultural University
2023-2024
Hebei University of Technology
2024
Beijing Institute of Technology
2024
Duke University
2021
Henan Agricultural University
2017-2020
Northwest A&F University
2019-2020
Tang Du Hospital
2019
Abstract Evidences of oxidative stress and mitochondrial dysfunction have been recognized in most clinical experimental liver diseases. SIRT3, a member NAD + -dependent deacetylases, is mainly localized mitochondria. So far, the role SIRT3 protecting hepatocytes against remains elusive. Herein, we found protein expression decreased tert -butyl hydroperoxide ( t -BHP)-treated AML12 cells vitro primary from CCl 4 -injured mice vivo . To further verify -BHP-induced injury, overexpressed cell...
Populus (poplar) tree species including hybrid varieties are considered as promising biomass feedstock for biofuels and biochemicals production due to their fast growing, short vegetative cycle, widely distribution. In this work, poplar was pretreated with acetic acid (AC) produce xylooligosaccharides (XOS), hydrogen peroxide-acetic (HPAC) used remove residual lignin in AC-pretreated enzymatic hydrolysis. The aim of work is XOS monosaccharides from by a two-step pretreatment method.The...
Nucleic acid therapeutics offer tremendous promise for addressing a wide range of common public health conditions. However, the
Ascorbic acid, also referred to as vitamin C (Vc), is an important nutrient found in fruits and vegetables that promotes produce quality human health. Rosa roxburghii underutilized natural fruit contains very high levels of Vc. However, the Vc content R. varies considerably during plant development ripening. To better understand molecular mechanisms underlie fluctuations at different developmental stages, we performed transcriptomic metabolomic analyses identified two significant gene...
ABSTRACT Background Glioblastoma multiforme (GBM) is a common and highly aggressive brain tumor with poor prognosis. However, the prognostic value of ferroptosis‐related genes (FRGs) their classification remains insufficiently studied. Objective This study aims to explore significance ferroptosis its risk model in GBM using multi‐omics approaches evaluate potential assessment. Methods Ferroptosis‐related were retrieved from databases such as FerrDB. The TCGA‐GBM CGGA‐GBM datasets used...
MDSCs, which are defined as a kind of negatively regulatory cells, could suppress T cell immune response in many tumor-bearing animal models and cancer patients. We supposed that MDSCs also contributed to the impaired antitumor immunity MDS. Here we demonstrated STAT3-ARG1 pathway be critical signal transduction regulated MDSCs-mediated immunosuppression. Increased was revealed MDS patients when compared healthy controls. Especially, performed higher activated STAT3 CCR2 expression high-risk...
Sugars and organic acids significantly impact fruit sensory quality, but their accumulation patterns regulatory mechanisms during the development of Rosa roxburghii are still unclear. We utilized transcriptomics metabolomics to investigate genes related sugar acid metabolism in roxburghii. Metabolomics data revealed that sucrose, glucose fructose were primary sugars, whereas citric malic fruit. constructed metabolic pathways major sugars identified five key involved synthesis. In addition,...
Abstract Background The plant hormone auxin is widely involved in growth, development, and morphogenesis, the TIR1/AFB AUX/IAA proteins are closely linked to rapid response signal transmission. However, their evolutionary history, historical patterns of expansion contraction, changes interaction relationships still unknown. Results Here, we analyzed gene duplications, interactions, expression TIR1/AFBs AUX/IAAs understand underlying mechanisms evolution. ratios range from 4:2 Physcomitrium...
Colorectal cancer (CRC) ranks as the third most prevalent global malignancy, marked by significant metastasis and post-surgical recurrence, posing formidable challenges to treatment efficacy. The integration of oligonucleotides with chemotherapeutic drugs emerges a promising strategy for synergistic CRC therapy. nanoformulation, lipid nanoparticle (LNP), presents capability achieve co-delivery In this study, we constructed nanoparticles, termed LNP-I-V microfluidics co-deliver miR159 mimics...
Abstract The single frequency ultrasound mode is difficult to achieve an higher enzymolysis efficiency. cost of protein enzymatic hydrolysis, using free enzyme because the cannot be used repeatedly. Therefore, effects triple-frequency (TFU) treatment on performance, kinetics, and thermodynamics immobilized Alcalase corn gluten meal (CGM) were investigated in this research. results showed that degree hydrolysis (DH), peptide concentration, ACE inhibitory activity, relative activity increased...
Increasing amounts of long noncoding RNAs (lncRNAs) have been shown to be involved in the development cancer. Recently, aberrant expression lncRNA forkhead box D2 adjacent opposite strand RNA1 (FOXD2‑AS1) has reported progression several types human However, function and mechanism FOXD2‑AS1 osteosarcoma (OS) are currently unclear. The present study aimed investigate OS. Firstly, it was revealed that levels were significantly upregulated OS tissues cells, compared with normal as determined...