A5079524009- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Cancer-related molecular mechanisms research
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Circular RNAs in diseases
- RNA modifications and cancer
- Advanced Nanomaterials in Catalysis
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Supramolecular Self-Assembly in Materials
- Cancer Research and Treatments
- Epigenetics and DNA Methylation
- Luminescence and Fluorescent Materials
- Cancer, Lipids, and Metabolism
- Immune cells in cancer
- DNA and Nucleic Acid Chemistry
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
- Extracellular vesicles in disease
- Photoacoustic and Ultrasonic Imaging
- Angiogenesis and VEGF in Cancer
- Protein Structure and Dynamics
- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
Southern Medical University
2025
First Affiliated Hospital of Wenzhou Medical University
2025
Wenzhou Medical University
2025
Shanghai University
2022-2024
Hanzhong People's Hospital
2024
China Medical University
2014-2023
National University of Singapore
2021-2023
First Hospital of China Medical University
2016-2023
Jilin University
2019-2022
Tongren Hospital
2014-2022
Delivery of therapeutics into the solid tumor microenvironment is a major challenge for cancer nanomedicine. Administration certain exogenous enzymes which deplete stromal components has been proposed as method to improve drug delivery. Here we present protein-free collagen depletion strategy delivery tumors, based on activating endogenous matrix metalloproteinases (MMP-1 and -2) using nitric oxide (NO). Mesoporous silica nanoparticles (MSN) were loaded with chemotherapeutic agent,...
Photodynamic therapy (PDT) of cancer is limited by tumor hypoxia. Platinum nanoparticles (nano-Pt) as a catalase-like nanoenzyme can enhance PDT through catalytic oxygen supply. However, the cytotoxic activity nano-Pt not comprehensively considered in existing methods to exert their multifunctional antitumor effects. Here, are loaded into liposomes via reverse phase evaporation. The clinical photosensitizer verteporfin (VP) lipid bilayer confer activity. Murine macrophage cell membranes...
A novel pH- and redox- dual-responsive tumor-triggered targeting mesoporous silica nanoparticle (TTTMSN) is designed as a drug carrier. The peptide RGDFFFFC anchored on the surface of nanoparticles via disulfide bonds, which are redox-responsive, gatekeeper well tumor-targeting ligand. PEGylated technology employed to protect ligands. monomethoxypolyethylene glycol (MPEG) with benzoic-imine bond, pH-sensitive, then connected "click" chemistry obtain TTTMSN. In vitro cell research...
During the last decade, using versatile, promising, and fascinating mesoporous silica nanoparticles (MSNs) as site-specific stimuli-responsive drug delivery systems (DDSs) has received concentrated research interest. As one of most attractive surface modification units, peptides have inherent bioactivity, biodegradability biocompatibility. Recent progresses in utilization versatile for functionalization MSNs to achieve cell-specific targeting, fluorescence imaging, intracellular diagnosis...
Liposomal drug delivery for cancer therapy can be limited due to leakage in circulation. Here, we develop a new method enhance the stability of actively loaded liposomal doxorubicin (DOX) through embedding stiff nanobowl water cavity. Nanobowl-supported DOX (DOX@NbLipo) resists influence plasma protein and blood flow shear force prevent leakage. This approach yields improved tumor sites enhanced antitumor efficacy. Compared alternative methods modifying liposome surface composition...
A redox-responsive mesoporous silica nanoparticle (RRMSN) was developed as a drug nanocarrier by noncovalent functionalization of MSNs with amphiphilic peptides containing the RGD ligand. The alkyl chain stearic acid (C18) thiol terminal group anchored on surface via disulfide bond, and peptide (AP) C18-DSDSDSDSRGDS coated self-assembly through hydrophobic interactions between octadecyl groups chains AP, which played role gatekeeper collectively. In vitro release profiles demonstrated that...
In view of the multiple pathological hallmarks tumors, nanosystems for sequential delivery various drugs whose targets are separately located inside and outside tumor cells desired improved cancer therapy. However, current is mainly achieved through enzyme- or acid-dependent degradation nanocarrier, which would be influenced by heterogeneous microenvironment, unloading efficiency drug acting on target usually unsatisfactory. Here, a light-triggered strategy based liposomal formulation...
Abstract Mesoporous silica nanoparticles (MSN) can load and deliver potentially synergistic anticancer agents such as small molecule cytotoxics (like doxorubicin, DOX) nucleic acids microRNA, miRNA). However, these cargos have different underlying chemical properties so overcoming respective intracellular delivery barriers is a key consideration. Strategies to DOX from MSN frequently employ pH‐driven mechanisms that are restricted the acidic environment of lysosomes. Conversely, strategies...
In this study, we report a novel redox-responsive mesoporous silica nanoparticle (MSN)-based nanocarrier, capping with therapeutic peptide ((RGDWWW)2KC) containing RGD target motif, for tumor targeting synergistic therapy, which is designated as TTSTMSN. The MSN was decorated tumor-targeting potential gatekeeper. two branched peptides rich tryptophans allowed the pores to be blocked via π–π stacking and hydrophobic interactions. Once drug loaded nanoparticles were taken up by cancer cells...
Abstract Chemoresistance conferred by leukemia propagating cells (LPCs) in a therapy‐induced niche (TI‐niche) within the bone marrow is one of main obstacles treatment. Effective approaches to circumvent TI‐niche protection and eliminate resident LPCs remain be exploited. Here, developed niche‐targeted nanosystem using leukemic cell membrane‐coated mesoporous silica nanoparticles (DA azo @CMSN) for co‐delivering daunorubicin chemotherapy TGFβRII neutralizing antibody (aTGFβRII) block...
The concept of immunogenic cell death (ICD) induced by chemotherapy as a potential synergistic modality for cancer immunotherapy has been widely discussed. Unfortunately, most chemotherapeutic agents failed to dictate effective ICD responses due their defects in inducing potent signaling. Here, we report dual-enzyme-instructed peptide self-assembly platform CPMC (CPT-GFFpY-PLGVRK-Caps) that cooperatively utilizes camptothecin (CPT) and capsaicin (Caps) promote engage systemic adaptive...
Aurora kinase A (AURKA) has been implicated in promoting myeloid and renal fibrosis. This study aimed to investigate the impact underlying mechanism of AURKA on liver fibrosis assess therapeutic potential MLN8237, a small-molecule inhibitor, preventing mice. The research used bioinformatics analysis immunohistochemistry staining fibrotic tissues from human mouse models expression. cellular localization was determined through double immunofluorescence primary hepatic stellate cells. RNA...
In this paper, we present WonderHuman to reconstruct dynamic human avatars from a monocular video for high-fidelity novel view synthesis. Previous avatar reconstruction methods typically require the input have full coverage of observed body. However, in daily practice, one has access limited viewpoints, such as front-view videos, making it cumbersome task previous unseen parts avatar. To tackle issue, WonderHuman, which leverages 2D generative diffusion model priors achieve high-quality,...
Tumor lymph node (LN) metastasis seriously affects the treatment prognosis. Studies have shown that nanoparticles with size of sub-50 nm can directly penetrate into LN metastases after intravenous administration. Here, we speculate through introducing targeting capacity, nanoparticle accumulation in would be further enhanced for improved local such as photothermal therapy. Trastuzumab-targeted micelles (< 50 nm) were formulated using a unique surfactant-stripping approach yielded...
Mitochondrion is a promising target in cancer therapy. However, gaining access to this organelle difficult due the obstacles cross complicated mitochondrial membrane. Cell-penetrating peptides (CPPs) with mitochondrion-targeting ability, named (MTPs), are efficient tools deliver exogenous therapeutics into mitochondria. Herein, we report several new MTPs, which can be readily synthesized via resin-based solid-phase peptide synthesis. In particular, MTP3 (compound 5), consisting of three...
Abstract The incidence of bladder cancer has increased in the last few decades, thus novel markers for early diagnosis and more efficacious treatment are urgently needed. It found that METTTL13 protein is aberrant expression variety human cancers METTL13 was involved oncogenic pathways. However, role been unexplored to date. Here, lower tissue samples cell lines than normal lines. downregulated late stages disease maintained at low level throughout tumor progression process based on node...