A5063956274- RNA modifications and cancer
- PI3K/AKT/mTOR signaling in cancer
- Advanced Breast Cancer Therapies
- Biochemical and Molecular Research
- Endoplasmic Reticulum Stress and Disease
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Cancer-related gene regulation
- Microtubule and mitosis dynamics
- Liver physiology and pathology
- Cancer-related molecular mechanisms research
- Genetic and Kidney Cyst Diseases
- Cancer Mechanisms and Therapy
Southern Medical University
2021-2025
Second Affiliated Hospital of Guangzhou Medical University
2024
Guangzhou Medical University
2023-2024
TCM-Intigrated Cancer Center of Southern Medical University
2021
Background:The therapeutic benefits of targeting follicle-stimulating hormone (FSH) receptor in treatment ovarian cancer are significant, whereas the role FSH progresses and underlying mechanism remains to be developed.Methods: Tissue microarray human cancer, tumor xenograft mouse model, vitro cell culture were used investigate carcinogenesis.siRNA, lentivirus inhibitors trigger inactivation genes, plasmids increase transcription genes.Specifically, pathological characteristic was assessed...
Abstract YTH domain family 2 (YTHDF2) is the first identified N6‐methyladenosine (m 6 A) reader that regulates status of mRNA. It has been reported overexpressed YTHDF2 promotes carcinogenesis; yet, its role in hepatocellular carcinoma (HCC) elusive. Herein, it demonstrated upregulated and can predict poor outcomes HCC. Decreased ubiquitination levels contribute to upregulation YTHDF2. Furthermore, heat shock protein 90 beta (HSP90β) STIP1 homology U‐box‐containing 1 (STUB1) physically...
Aurora kinase A (AURKA) has been implicated in promoting myeloid and renal fibrosis. This study aimed to investigate the impact underlying mechanism of AURKA on liver fibrosis assess therapeutic potential MLN8237, a small-molecule inhibitor, preventing mice. The research used bioinformatics analysis immunohistochemistry staining fibrotic tissues from human mouse models expression. cellular localization was determined through double immunofluorescence primary hepatic stellate cells. RNA...
Long noncoding RNAs (lncRNAs) have been substantially reported to critical roles in regulating tumorigenesis recent years. However, the expression pattern and biological function of SNHG17 hepatocellular carcinoma (HCC) remain unclear. Bioinformatics analysis qRT-PCR were performed detect HCC tissues, adjacent nontumorous cell lines. The effect on proliferation, migration, apoptosis was investigated by knockdown overexpressing RNA sequencing utilized explore underlying mechanism. Utilizing...
Hypothyroidism is a common adverse reaction in clinical multi-target tyrosine kinase inhibitor (TKI) and may be used as predictor of efficacy TKI drugs. Studies show that hypothyroidism significantly associated with good prognosis patients renal cell carcinoma treated TKI, which related to inhibition vascular endothelial growth factor receptor pathway, potential off-target effects proliferation. Whereas the hepatocellular who received therapy, an indicator poor prognosis, T3/TR pathway...