A5039288943- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Advanced biosensing and bioanalysis techniques
- Click Chemistry and Applications
- RNA Interference and Gene Delivery
- Radio Frequency Integrated Circuit Design
- Carbohydrate Chemistry and Synthesis
- Protein Degradation and Inhibitors
- Traditional and Medicinal Uses of Annonaceae
- Cocoa and Sweet Potato Agronomy
- Quantum Dots Synthesis And Properties
- Luminescence and Fluorescent Materials
- Cancer therapeutics and mechanisms
- Electromagnetic Compatibility and Noise Suppression
- Nanoparticle-Based Drug Delivery
- Sulfur Compounds in Biology
- Radical Photochemical Reactions
- Molecular Sensors and Ion Detection
- Chemical Synthesis and Analysis
- Silicon Carbide Semiconductor Technologies
- Advanced Nanomaterials in Catalysis
- Advanced Power Amplifier Design
- Advanced Thermoelectric Materials and Devices
- Antibiotic Resistance in Bacteria
- Inflammasome and immune disorders
Sun Yat-sen University
2019-2024
Guangxi Medical University
2023-2024
National University of Singapore
2000-2022
Chinese University of Hong Kong
2014-2021
Tianjin University
2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
Central South University
2021
Xiangya Hospital Central South University
2021
Guangzhou Institutes of Biomedicine and Health
2010-2014
Chinese Academy of Sciences
2010-2014
Rapid emergence of multidrug resistant (MDR) "superbugs" poses a severe threat to global health. Notably, undeveloped diagnosis and concomitant treatment failure remain highly challenging. Herein, we report sonotheranostic strategy achieve bacteria-specific labeling visualized sonodynamic therapy (SDT). Using maltohexaose-decorated cholesterol bacteria-responsive lipid compositions, smart nanoliposomes platform (MLP18) was developed for precise delivery purpurin 18, potent sonosensitizer...
Abstract Advances in targeted covalent inhibitors (TCIs) have been made by using lysine‐reactive chemistries. Few aminophiles possessing balanced reactivity/stability for the development of cell‐active TCIs are however available. We report herein activity‐based probes (ABPs; 2–14 ) based on chemistry aryl fluorosulfates (ArOSO 2 F) capable global reactivity profiling catalytic lysine human kinome from mammalian cells. concurrently developed reversible ABPs ( 15 / 16 installing...
Development of new photosensitizers (PSs) with high photodynamic efficacy and minimal side effects is great interest in therapy (PDT). In this work, we reported several pyridine-embedded phenothiazinium (pyridophenothiazinium) dyes, which could be conveniently synthesized a few short steps acted as highly efficient potent PSs to selectively localize lysosomes photosensitively kill cancer cells. Among them, compound 5, possessed the ability promoting intracellular reactive oxygen species...
Increasing threats from both pathogenic infections and antibiotic resistance highlight the pressing demand for nonantibiotic agents alternative therapies. Herein, we report several new phenothiazinium-based derivatives, which could be readily synthesized via fragment-based assembly, exhibited remarkable bactericidal activities in vitro vivo. Importantly, contrast to numerous clinically preclinically used antibacterial photosensitizers, these compounds were able eliminate various types of...
Photodynamic therapy (PDT) is a minimally invasive treatment for many diseases, including infections and tumors. Nevertheless, clinical utilization of PDT severely restricted due to the shortcomings photosensitizers, especially their low water solubility poor tumor selectivity. iRGD (internalizing RGD, CRGDKGPDC), nine-unit cyclic peptide, was applied as an active ligand realize homing tissue penetration. Herein, we innovatively fabricated novel OFF-ON mode iRGD-based peptide amphiphile (PA)...
Nitroreductase (NTR), a common enzymatic biomarker of hypoxia, is widely used to evaluate tumor microenvironments. To date, numerous optical probes have been reported for NTRs detection. Approaches capable concisely guiding the probe design suitable deep-tissue imaging, however, are still lacking. As such, direct imaging endogenous NTR activities from tumors derived cancer patients thus far not possible. Herein, aided by computational calculations, authors successfully developed series...
Cancer therapies based on energy conversion, such as photothermal therapy (PTT, light-to-thermal conversion) and photodynamic (PDT, light-to-chemical have attracted extensive attention in preclinical research. However, the PTT-related hyperthermia damage to surrounding tissues shallow penetration of PDT-applied light prevent further advanced clinical practices. Here, we developed a thermoelectric (TET) materials constructed p-n heterojunction (SrTiO3/Cu2Se nanoplates) principle...
Annonaceous acetogenins, a large family of naturally occurring polyketides isolated from various species the plant genus Annonaceae, have been found to exhibit significant cytotoxicity against variety cancer cells. Previous studies showed that these compounds could act on mitochondria complex-I and block corresponding electron transport chain terminate ATP production. However, more details mechanisms action remain ambiguous. In this study we tested effects set mimetics annonaceous acetogenin...
Mitochondrion is a promising target in cancer therapy. However, gaining access to this organelle difficult due the obstacles cross complicated mitochondrial membrane. Cell-penetrating peptides (CPPs) with mitochondrion-targeting ability, named (MTPs), are efficient tools deliver exogenous therapeutics into mitochondria. Herein, we report several new MTPs, which can be readily synthesized via resin-based solid-phase peptide synthesis. In particular, MTP3 (compound 5), consisting of three...
Since Hydrogen Sulfide (H2S) was recognized as a gas transmitter, its detection and quantification have become hot research topic among chemists biologists. In this area, fluorescent probes shown great advantages: fast strong response, low limit easy manipulation. Here we developed new probe that detected H2S selectively various bioactive inorganic salts. This based on the core structure of fluorescein reacted with through azide-reduction. Great linearity achieved correlating fluorescence...
Abstract Sepsis is a leading cause of death worldwide. This syndrome commonly accompanied by overactivation coagulation, excessive reactive oxygen species (ROS), and inflammatory cytokine storm. Notably, disseminated intravascular coagulation (DIC) accounts for around 40% sepsis‐associated deaths. However, anticoagulant therapy still difficult sepsis treatment because the lethal bleeding side effects. Although relationship between ROS storm has been described clearly, pathogenic role in DIC,...
Abstract Sepsis is a life-threatening syndrome with disturbed host responses to severe infections, accounting for the majority of death in hospitalized patients. However, effective medicines are currently scant clinics due poor understanding exact underlying mechanism. We previously found that blocking caspase-11 pathway (human orthologs caspase-4/5) rescue coagulation-induced organ dysfunction and lethality sepsis models. Herein, we screened our existing chemical pools established lab using...
Annonaceous acetogenins are a large family of naturally occurring polyketides exhibiting remarkable anticancer activities. The first generation annonaceous acetogenin mimetic (1, AA005) exhibits comparable activity as that natural products and presents much higher selectivity between cancer normal cells. In this work, we report the design, synthesis, evaluation new series compound 1 analogues in which variety conformation-constrained fragments were embedded left hydrocarbon chain part....