A5000170594- Nanoplatforms for cancer theranostics
- Magnesium Alloys: Properties and Applications
- Electrophoretic Deposition in Materials Science
- Nanoparticle-Based Drug Delivery
- Advanced Photocatalysis Techniques
- Aluminum Alloys Composites Properties
- Photodynamic Therapy Research Studies
- Supercapacitor Materials and Fabrication
- Multiferroics and related materials
- Conducting polymers and applications
- Advancements in Battery Materials
- MXene and MAX Phase Materials
- Corrosion Behavior and Inhibition
- Photoacoustic and Ultrasonic Imaging
- Quantum Dots Synthesis And Properties
- Bone Tissue Engineering Materials
- RNA Interference and Gene Delivery
- Magnetic and transport properties of perovskites and related materials
- Advanced Sensor and Energy Harvesting Materials
- Electrocatalysts for Energy Conversion
- Ferroelectric and Piezoelectric Materials
- Tendon Structure and Treatment
- Luminescence and Fluorescent Materials
- 2D Materials and Applications
- Ultrasound and Cavitation Phenomena
Henan Academy of Sciences
2025
First Affiliated Hospital of Henan University
2023-2025
Natural Resources Canada
2014-2024
Shanghai Institute of Ceramics
2020-2024
Chinese Academy of Sciences
2021-2024
Guilin University of Electronic Technology
2024
South China Normal University
2024
First Affiliated Hospital of Zhengzhou University
2019-2023
China University of Petroleum, East China
2023
University of Chinese Academy of Sciences
2020-2023
Antibiotic-free methods hold particular promise for preventing and controlling multidrug-resistant (MDR) bacterial infection via eradiation of bacteria their pathogenic virulence. A facile bioinspired strategy is presented bridging antibacterial sonodynamic therapy antivirulence immunotherapy. As a proof-of-concept, an antibody which neutralizes alpha-toxin methicillin-resistant Staphylococcus aureus (MRSA) genetically engineered on to the surface cell membrane nanovesicles, then undergo...
Micro/nanorobots have been extensively explored as a tetherless small-scale robotic biodevice to perform minimally invasive interventions in hard-to-reach regions. Despite the emergence of versatile micro/nanorobots recent years, matched vivo development remains challenging, limited by unsatisfactory integration core functions. Herein, we report polydopamine (PDA)-coated magnetic microswimmer consisting magnetized Spirulina (MSP) matrix and PDA surface. Apart from properties existing MSP...
Rapid emergence of multidrug resistant (MDR) "superbugs" poses a severe threat to global health. Notably, undeveloped diagnosis and concomitant treatment failure remain highly challenging. Herein, we report sonotheranostic strategy achieve bacteria-specific labeling visualized sonodynamic therapy (SDT). Using maltohexaose-decorated cholesterol bacteria-responsive lipid compositions, smart nanoliposomes platform (MLP18) was developed for precise delivery purpurin 18, potent sonosensitizer...
Abstract To address the urgent need for effective sonodynamic therapy (SDT), a facile and efficient strategy is developed fabricating new class of sonotheranostics. Herein, Fe(III)‐porphyrin nano‐sonosensitizer prepared by one‐step coordination synthesis, then anchored with Bis(DPA‐Zn)‐RGD manganese superoxide dismutase (SOD2) siRNA. Benefiting from delicate interactions Fe(III)‐coordinated nanoformulations, highly potent sono/gene combinational guided fluorescence/magnetic resonance imaging...
Abstract The clinical applications of magnetic hyperthermia therapy (MHT) have been largely hindered by the poor magnetic-to-thermal conversion efficiency MHT agents. Herein, we develop a facile and efficient strategy for engineering encapsulin-produced iron oxide nanocomposites (eMIONs) via green biomineralization procedure. We demonstrate that eMIONs excellent saturation remnant magnetization properties, featuring superior with an ultrahigh specific absorption rate 2390 W/g to overcome...
We report the rational design of coordination-driven self-assembly metal-organic nanostructures for multifunctional nanotheranostics. Zinc(II) coordination-based nano-formulations capable loading indocyanine green (ICG) and therapeutic genes were prepared to achieve a fluorescence/photoacoustic imaging-guided combination photo/gene therapy strategy. showed enhanced theranostic capability zinc(II)-dipicolylamine-assisted assembly ICG, as well simultaneous targeted gene delivery in an...
Abstract Although ultrasound‐based therapeutic strategies have achieved great success in the battle against antibiotic‐resistant bacterial infections, various sonodynamic treatments still suffer from poor efficiency, failing to completely eradicate infections. Thus, more potent are urgently required. Herein, a novel ultrasound‐driven treatment modality, sonoactivated chemodynamic therapy (SCDT), is proposed, which shows robust generation of superoxide anion and destructive hydroxyl radical...
Pure aluminum powder was successfully sprayed on AZ31B extrusion flat and round coupons at low temperature. The corrosion fatigue behavior of the coated uncoated samples were examined by performing accelerated tests. resistance with without coating investigated based ASTM B117 standard salt spray a concentration 5% NaCl 36 °C, 100% relative humidity. bare producing thin film 3.5% solution surface via integrating chamber into rotating bending testing machine. Al provided significant...
A multi-level supramolecular system produced by single-step Fe<sup>3+</sup>-mediated ionic crosslinking self-assembly can overcome the critical issues of current sonodynamic therapy (SDT) and address need to monitor therapeutic effects<italic>in vivo</italic>with a non-invasive approach.
Abstract Rapid emergence of antibiotic resistance facilitates the development a number novel‐acting alternatives. Among these emerging approaches, metal oxide nanoparticles receive great attention due to their distinctive performance in antimicrobial stewardship. These can not only target cell wall, membrane, and cytoplasmic contents disrupt cellular homeostasis, but also generate reactive oxygen species highly cytotoxic for virtually all microorganisms without concern. By taking advantage...
The ability to selectively kill cancerous cell populations while leaving healthy cells unaffected is a key goal in oncology. use of nanovesicles (NVs) as chemotherapeutic delivery vehicles has been recently proven successful, yet monotherapy with monomodalities remains significant limitation for solid tumor treatment. Here, proof principle, novel cell-membrane-derived NVs that can display full-length monoclonal antibodies (mAbs) engineered. high affinity and specificity mAb tumor-specific...
Abstract In this study, porous chitosan/collagen scaffolds were prepared through a freeze‐drying process, and loaded with the plasmid vector encoding human bone morphogenetic protein‐7 (BMP‐7) gene. To investigate feasibility efficacy of gene‐activated scaffold on dental tissue engineering, pulp stem cells (DPSCs) seeded in for vitro vivo study. results indicated that can be transfected successfully by secrete BMP‐7 until day 24. Evaluation DNA content, ALP activity, calcium SEM, real‐time...
Development of new photosensitizers (PSs) with high photodynamic efficacy and minimal side effects is great interest in therapy (PDT). In this work, we reported several pyridine-embedded phenothiazinium (pyridophenothiazinium) dyes, which could be conveniently synthesized a few short steps acted as highly efficient potent PSs to selectively localize lysosomes photosensitively kill cancer cells. Among them, compound 5, possessed the ability promoting intracellular reactive oxygen species...