A5010497090- Geomechanics and Mining Engineering
- Nanoplatforms for cancer theranostics
- Geoscience and Mining Technology
- Nanoparticle-Based Drug Delivery
- Membrane Separation Technologies
- Phase Change Materials Research
- Metallurgical Processes and Thermodynamics
- Membrane-based Ion Separation Techniques
- Molten salt chemistry and electrochemical processes
- Adsorption and Cooling Systems
- Graphene research and applications
- Advanced Nanomaterials in Catalysis
- Membrane Separation and Gas Transport
- Thermal Expansion and Ionic Conductivity
- Cancer Research and Treatments
- Nuclear Materials and Properties
- Natural product bioactivities and synthesis
- Rock Mechanics and Modeling
- Advanced biosensing and bioanalysis techniques
- Ginseng Biological Effects and Applications
- Blasting Impact and Analysis
- Immune cells in cancer
- Ziziphus Jujuba Studies and Applications
- Extracellular vesicles in disease
- CO2 Sequestration and Geologic Interactions
Tongren Hospital
2019-2025
Shanghai Jiao Tong University
2019-2025
Integrated Chinese Medicine (China)
2025
Shanghai University of Engineering Science
2022-2024
Fuzhou University
2024
Chinese Academy of Sciences
2021-2023
Shanghai Institute of Applied Physics
2021-2023
University of Chinese Academy of Sciences
2023
State Key Laboratory of Oncogene and Related Genes
2020-2022
Qinghai University
2021-2022
Delivery of therapeutics into the solid tumor microenvironment is a major challenge for cancer nanomedicine. Administration certain exogenous enzymes which deplete stromal components has been proposed as method to improve drug delivery. Here we present protein-free collagen depletion strategy delivery tumors, based on activating endogenous matrix metalloproteinases (MMP-1 and -2) using nitric oxide (NO). Mesoporous silica nanoparticles (MSN) were loaded with chemotherapeutic agent,...
Photodynamic therapy (PDT) of cancer is limited by tumor hypoxia. Platinum nanoparticles (nano-Pt) as a catalase-like nanoenzyme can enhance PDT through catalytic oxygen supply. However, the cytotoxic activity nano-Pt not comprehensively considered in existing methods to exert their multifunctional antitumor effects. Here, are loaded into liposomes via reverse phase evaporation. The clinical photosensitizer verteporfin (VP) lipid bilayer confer activity. Murine macrophage cell membranes...
Liposomal drug delivery for cancer therapy can be limited due to leakage in circulation. Here, we develop a new method enhance the stability of actively loaded liposomal doxorubicin (DOX) through embedding stiff nanobowl water cavity. Nanobowl-supported DOX (DOX@NbLipo) resists influence plasma protein and blood flow shear force prevent leakage. This approach yields improved tumor sites enhanced antitumor efficacy. Compared alternative methods modifying liposome surface composition...
In view of the multiple pathological hallmarks tumors, nanosystems for sequential delivery various drugs whose targets are separately located inside and outside tumor cells desired improved cancer therapy. However, current is mainly achieved through enzyme- or acid-dependent degradation nanocarrier, which would be influenced by heterogeneous microenvironment, unloading efficiency drug acting on target usually unsatisfactory. Here, a light-triggered strategy based liposomal formulation...
Abstract Living cell‐based drug delivery systems (LC‐DDSs) are limited by adverse interactions between drugs and carrier cells, typically drug‐induced toxicity to cells restriction of on release. Here, a method is established adsorb nanocarriers externally living thereby reducing cytotoxicity caused uptake realizing improved release at the disease site. It found that divalent metal ion‐phenolic network (MPN) affords adhesion poly (lactic‐co‐glycolic acid) nanoparticles onto macrophage (Mφ)...
Abstract Chemoresistance conferred by leukemia propagating cells (LPCs) in a therapy‐induced niche (TI‐niche) within the bone marrow is one of main obstacles treatment. Effective approaches to circumvent TI‐niche protection and eliminate resident LPCs remain be exploited. Here, developed niche‐targeted nanosystem using leukemic cell membrane‐coated mesoporous silica nanoparticles (DA azo @CMSN) for co‐delivering daunorubicin chemotherapy TGFβRII neutralizing antibody (aTGFβRII) block...
The presence of lymph node (LN) metastases guides cancer staging and worsens prognoses. Incomplete lymphadenectomy metastatic LNs may end up with disease recurrence, while excessive resection can result in increased postoperative complications even no survival benefit. Thus, effective non-invasive methods to treat would be highly desirable. Here, we develop an enzyme-responsive formulation small-sized doxorubicin-loaded mesoporous silica nanoparticles (DMSN, 40 nm) encapsulated nanoliposomes...
Abstract Metal‐phenolic networks (MPNs) are an emerging class of supramolecular surface modifiers with potential use in various fields including drug delivery. Here, the development a unique MPN‐integrated core‐satellite nanosystem (CS‐NS) is reported. The “core” component CS‐NS comprises liposome loaded EDTA (a metal ion chelator) aqueous core and DiR near‐infrared photothermal transducer) bilayer. “satellite” mesoporous silica nanoparticles (MSNs) encapsulating doxorubicin coated Cu 2+...
Tumor lymph node (LN) metastasis seriously affects the treatment prognosis. Studies have shown that nanoparticles with size of sub-50 nm can directly penetrate into LN metastases after intravenous administration. Here, we speculate through introducing targeting capacity, nanoparticle accumulation in would be further enhanced for improved local such as photothermal therapy. Trastuzumab-targeted micelles (< 50 nm) were formulated using a unique surfactant-stripping approach yielded...
Corrosion behavior of 304 stainless steel in molten NaNO3-NaCl-NaF salt and vapor has been studied at 450 °C. The results showed that the samples suffered weight loss, surface oxides, i.e. Fe2O3 FeCr2O4 characterized by XRD, were formed after corrosion. oxide layer was about 1.1 μm thickness corrosion salt, which relatively homogeneous dense. Whereas, distribution oxides not even, a shedding phenomenon observed vapor. This is mainly attributed to existence NO2 NO determined thermogravimetric...
Saikosaponin A (SSA), a main triterpenoid saponin component from Radix Bupleurum , has been revealed to have variety of pharmacological activities. However, whether SSA can inhibit angiogenesis, key step in solid tumor progression, remains unknown. In this study, we demonstrated that could powerfully suppress the proliferation, migration, and tube formation human umbilical vein endothelial cells. also significantly inhibited angiogenesis models chick embryo chorioallantoic membrane Matrigel...
Macrophages In article number 2214842, Chao Fang and co-workers develop a macrophage-drug delivery system (Mφ-DDS) with doxorubicin (DOX)-loaded polymeric nanoparticles (NPs) on cell surface, named as [email protected]φ. At the tumor site, photothermal effect can disintegrate cell-nanoparticle composites liberate DOX-NP for improved cellular uptake chemotherapy.
In this study, polyelectrolyte multilayers were fabricated on a polystyrene (PS) plate using Layer-by-Layer (LbL) self-assembly technique. The resulting functional platform showed improved performance compared with conventional enzyme-linked immunosorbent assay (ELISA) systems. Poly(diallyldimethylammonium chloride) (PDDA) and poly(acrylic acid) (PAA) used as cationic anionic polyelectrolytes. On the negatively-charged (PDDA/PAA)₃ hydrophilic PAA surface could efficiently decrease magnitude...