A5100369086- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Organ Transplantation Techniques and Outcomes
- Diet, Metabolism, and Disease
- Liver physiology and pathology
- Liver Diseases and Immunity
- MicroRNA in disease regulation
- Advanced Proteomics Techniques and Applications
- Lipid metabolism and biosynthesis
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis C virus research
- Endoplasmic Reticulum Stress and Disease
- Metabolism, Diabetes, and Cancer
- Lipid metabolism and disorders
- Biological Research and Disease Studies
- Peroxisome Proliferator-Activated Receptors
- Diet and metabolism studies
- Cerebrovascular and Carotid Artery Diseases
- Metabolomics and Mass Spectrometry Studies
- Eicosanoids and Hypertension Pharmacology
- Cardiovascular Disease and Adiposity
- Inflammasome and immune disorders
- Adipose Tissue and Metabolism
- Iron Metabolism and Disorders
First Affiliated Hospital of Henan University
2023
China Pharmaceutical University
2021-2023
Harbin Medical University
2023
Second Affiliated Hospital of Harbin Medical University
2023
Lanzhou University
2022
Liaoning Shihua University
2022
Jiangxi Agricultural University
2022
China Agricultural University
2021
First Hospital of Shanxi Medical University
2020
Shanxi Medical University
2020
Upregulated de novo lipogenesis (DNL) plays a pivotal role in the progress of nonalcoholic fatty liver disease (NAFLD). Cytoplasmic citrate flux, mediated by plasma membrane transporter (SLC13A5), mitochondrial carrier (SLC25A1), and ATP-dependent lyase (ACLY), determines central carbon source for acetyl-CoA required DNL. Curcumin, widely accepted dietary polyphenol, can attenuate lipid accumulation NAFLD. Here, we first investigated lipid-lowering effect curcumin against NAFLD oleic...
The purpose of this study was to develop and evaluate a scoring system for assessing reperfusion status based on arterial spin labeled (ASL) perfusion MRI in acute ischemic stroke (AIS) patients receiving thrombolysis and/or endovascular treatment. Pseudo-continuous ASL with background suppressed 3D GRASE acquired along DWI 90 within 24 h post-treatment. An automatic (auto-RPS) devised the Alberta Stroke Program Early CT Score (ASPECTS) template, compared manual RPS DWI-ASPECTS. TICI...
Nonalcoholic steatohepatitis (NASH) is a global public health challenge. Overwhelmed oxidative stress and impaired autophagy play an important role in the progression of NASH. Chemerin adipokine that has attracted much attention inflammation metabolic diseases. This study aimed to examine effects chemerin NASH its association with autophagy. In this study, was found significantly ameliorate high-fat diet (HFD) induced NASH, marked by decreased serum levels alanine aminotransferase (ALT),...
Metabolism-associated fatty liver disease (MAFLD) is one of the most common causes disease; however, underlying processes remain unknown. This study aimed to investigate changes free acids (FFA) on expression genes related AMP-activated protein kinase (AMPK) signaling pathway in primary hepatocytes laying hens. The hens were treated with FFA (containing a 2:1 ratio oleic and palmitic acids) for 24 h. significantly increased lipid droplet accumulation, decreased glycogen synthesis, levels...
The hepatic SLC13A5/SLC25A1-ACLY signaling pathway, responsible for maintaining the citrate homeostasis, plays a crucial role in pathogenesis of non-alcoholic fatty liver disease (NAFLD). Bempedoic acid (BA), an ACLY inhibitor commonly used managing hypercholesterolemia, has shown promising results addressing steatosis. This study aimed to elucidate intricate relationships processes lipogenesis among SLC13A5, SLC25A1 and ACLY, examine therapeutic potential BA NAFLD, providing insights into...
Risk adjustment is essential for valid comparison of patients' health outcomes or performances care providers. Several risk methods liver diseases are commonly used but the optimal approach unknown. This study aimed to compare common predicting in-hospital mortality in cirrhosis patients using electronic medical record (EMR) data. The sample was derived from Beijing YouAn hospital between 2010 and 2014. Previously validated EMR extraction were applied define disease conditions, Charlson...
Chronic viral hepatitis (CVH) is the root cause of liver fibrosis and subsequent hepatocellular carcinoma (HCC). We conducted a cross-sectional, observational study based on medical records primary data collection from patients with CVH who were admitted in five hospitals across China between February September 2013 to determine prevalence elevated cholestatic enzymes (ALP and/or GGT above ULN) discharged Chinese as outcome secondarily evaluated relationship these disease severity. Majority...
Researchers have shown that bone mesenchymal stem cells (BMSCs) can alleviate the progression of liver cirrhosis; however, it is unclear how exactly BMSCs function to cure disease. In this study, we used bioinformatics methods assess differentially expressed genes (DEGs) in cirrhosis and found a significantly upregulated gene, Fstl1, cirrhosis. vivo vitro experiments showed compared with those disease model group, mRNA, protein expression levels Fstl1 were reduced after treatment, β-Catenin...
This study was performed to evaluate the efficacy of metformin on liver fat content (LFC) in first episode schizophrenia patients with olanzapine-induced weight gain, and relationship between change LFC other metabolic indices.In a double-blind study, clinically stable inpatients first-episode under olanzapine monotherapy who gained more than 7% their baseline were randomly assigned two groups; one plus (1,000 mg/day) (metformin group) placebo (placebo for 16 weeks. All continued maintain...
Objective The incidence of metabolic syndrome (MS) increases after liver transplantation. This study was performed to evaluate the impact MS on patients' quality life Methods We collected medical records 152 patients during their post-liver transplantation outpatient follow-up. Quality assessed using Medical Outcomes Study 36-Item Short Form Health Survey. Data general condition as well MS-related indicators were in all patients. Based diagnostic criteria proposed by International Diabetes...
Purpose: This study utilized network pharmacology, molecular docking, dynamics simulation, and in vitro experimental verification to explore the mechanisms of action by which asiatic acid (AA) inhibits acetaldehyde-induced activation hepatic stellate cells (HSCs). Methods: Databases were screened identify intersections between AA alcoholic liver fibrosis. Gene ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) Enrichment analysis performed, followed docking simulation predict further...
Abstract Liver fibrosis occurs during chronic liver disease. Advanced results in cirrhosis, failure and often requires transplantation. However, due to the lack of human models, mechanisms underlining pathogenesis remain unclear. Recent studies implicated a central role deranged lipid metabolism its pathogenesis. In this study, we generated LEPTIN-deficient ( LEPTIN -/- ) pigs using zinc finger nuclease technology investigate associated with obesity. The showed increased body fat significant...
Abstract Both pathogenesis and detection of liver fibrosis early cirrhosis are elusive. Our study focused on role microRNAs (miRNAs) as predictive biomarkers cirrhosis. Methods: We recruited patients with chronic hepatitis B background divided them into three subgroups according to the pathological staging results: no group (CHB 11, 12.0%), but without (LF 41, 44.6%), (LC 40, 43.4%). Results: Levels miR-122 in CHB LF were significantly elevated compared LC group. Meanwhile, upregulation...