A5101760023- Educational Technology and Assessment
- Liver Disease Diagnosis and Treatment
- Computational Drug Discovery Methods
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis C virus research
- Functional Brain Connectivity Studies
- Angiogenesis and VEGF in Cancer
- Cancer-related gene regulation
- Intracerebral and Subarachnoid Hemorrhage Research
- Peroxisome Proliferator-Activated Receptors
- Fungal Biology and Applications
- Cancer-related Molecular Pathways
- Higher Education and Teaching Methods
- Phytochemistry and Biological Activities
- Eicosanoids and Hypertension Pharmacology
- Advanced Computational Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Neurological Disease Mechanisms and Treatments
- Nuclear Receptors and Signaling
- Inflammatory Biomarkers in Disease Prognosis
- AI and Big Data Applications
- Brain Tumor Detection and Classification
- Educational Technology and Pedagogy
- Advanced Computing and Algorithms
- Library Collection Development and Digital Resources
Shanghai Sixth People's Hospital
2011-2025
Shanghai Jiao Tong University
2022-2025
Hengshui University
2012-2024
Shaanxi Normal University
2019-2024
Guangxi Normal University
2024
Baotou Central Hospital
2022-2023
Kunming Medical University
2014-2023
Anqing City Hospital
2022-2023
Chongqing Medical University
2023
Fujian Agriculture and Forestry University
2023
The aim of this study was to investigate the potential dynamic resistance exercise generate skeletal muscle-derived follistatin like-1 (FSTL1), which may induce cardioprotection in rats following myocardial infarction (MI) by inducing angiogenesis.Male, adult Sprague-Dawley were randomly divided into 5 groups (n = 12 each group): sham group (S), sedentary MI (MI), + (MR), adeno-associated virus (AAV)-FSTL1 injection (MA), and AAV-FSTL1 (MAR). vector prepared molecular biology methods...
Abstract Background Intracerebral hemorrhage (ICH) remains a devastating neurological disorder with limited therapeutic options. Neural stem cell (NSC)‐based therapies have emerged as potential regenerative approach, yet the molecular mechanisms regulating NSC behavior require further elucidation. The role of miR‐21 in differentiation and proliferation during ICH recovery unexplored. Methods In vitro cultures were analyzed for expression dynamics via qPCR. Lentiviral overexpression knockdown...
Asthma is a common inflammatory respiratory disease with increasing incidence worldwide. This study aimed to investigate the mechanism of miR-146a-5p in reducing allergic airway inflammation by inhibiting NLRP3 inflammasome activation macrophages.Allergic mouse models were established ovalbumin stimulation, and mice treated agomir oe-TIRAP 3 h before OVA stimulation. The pathological changes lung tissues observed hematoxylin-eosin staining. hyperresponsiveness examined. level was detected...
As a non-invasive brain imaging technology, functional magnetic resonance (fMRI) provides basic tool for network modeling and disease diagnosis. Problems, such as large number of parameters, low training efficiency, poor interpretability, are encountered in mainstream models because the high complexity fMRI networks. To solve these problems, novel structure feature combined graph neural (SFC-GNN) with parameters is proposed. In particular, SFC-GNN composed 1) convolution layer region...
Chemical investigation of Penicillium sp. GDGJ-N37, a Sophora tonkinensis-associated fungus, yielded two new azaphilone derivatives, N-isoamylsclerotiorinamine (1) and 7-methoxyl-N-isoamylsclerotiorinamine (2), four known azaphilones (3–6), together with chromone penithochromones X Y (7 8). Their structures were elucidated based on spectroscopic data, CD spectrum, semi-synthesis. Sclerotioramine (3) showed significant antibacterial activities against B. subtilis S. dysentery, it also most...
Abstract Autism spectrum disorder (ASD) is a neurodevelopmental characterized by impaired social interactions, communication deficits and repetitive behaviors. A study of autistic human subjects has identified RFWD2 as susceptibility gene for autism, patients have 3 copies the gene. The role an E3 ligase in neuronal functions, its contribution to pathophysiology ASD, remain unknown. We generated knockin mice model condition high dosage . found that heterozygous ( Rfwd2 +/− ) male exhibited...
Background and purpose: Lipopolysaccharide (LPS) is an important factor that induce severe inflammation, resulting in multiple types of diseases. It reported LPS-induced inflammation related to the activation NF-κB signal pathway reactive oxygen species (ROS)-induced oxidative stress. Azilsartan, angiotensin II type 1 (AT1) receptor blocker, has been licensed as a new generation Sartan antihypertensive drugs. However, effects azilsartan have not before. The present study aims investigate...
KRAS and BRAF targets are involved in the epidermal growth factor receptor pathway. most frequent driver mutations cancer.The objective of study was to present recent developments target target.KRAS were analyzed by US patent analysis. All granted documents from January 2002 November 2021 retrieved.The results showed both be attractive for developing anticancer drugs. The technology RNA interference has been developed drug discovery related target. Our indicates that structural screening...
A Gram-negative, non-motile, non-sporulating bacterial strain, designated LYX05(T), was isolated from coastal sediment of Qingdao, China, on the coast Yellow Sea. Strain LYX05(T) aerobic and heterotrophic. The strain grew optimally at 37 °C pH 7.5 in presence 2% (w/v) NaCl. Colonies were 1-2 mm diameter, circular, reddish orange shiny with entire edges marine agar medium. Cells rods (0.3-0.5 µm wide 0.8-1.6 long). dominant fatty acids iso-C(15:0) (40.82%) C(16:0) (10.45%). DNA G+C content...
Metformin (MET) is a well-known anti-diabetic drug that also has anti-cancer effects. However, high therapeutic doses of MET on cancer cells and the low efficacy combinatory approaches limit its clinical application. Recent studies have shown chrysin (CHR) can improve pharmaceutical by suppressing human telomerase reverse transcriptase (hTERT) cyclin D1 gene expression. This study aimed to develop different ratios methoxy poly(ethylene glycol)-b-poly(e-caprolactone) (MPEG-PCL) micelles for...
Abstract With the reform and development of modern education curriculum, focus preschool has changed from focusing on “learning results” to process” young children, deep learning, as a hot trend reform, is an important way implement in pre-school education, which based problem-solving, emphasizing application migration, reflective construction. Deep educational that emphasizes transfer application, focuses reflection construction, education. This study first explores connection between...
Aiming at the high complexity of fMRI data and great spatial dependence existing methods, a whole-brain functional segmentation algorithm with low computational overhead structure is proposed for individual-level in 3-D space. First, information connectivity each voxel are utilized presegmentation to create compact functionally consistent super voxels, then extracts features, such as average coordinates time series level reduce effort algorithm, performs cut-free manner obtain optimal graph...
Background: As antioxidant and anti-inflammatory agents, carbonic anhydrase inhibitors can exert potentially useful therapeutic effects following central nervous system trauma, including intracerebral hemorrhage (ICH). However, the efficacy of ethoxyzolamide (ETZ) as a novel inhibitor for ICH has not yet been determined. Methods: An autologous blood injection method was used to establish models, which were then intraperitoneal ETZ on ICH. Neuronal damage, apoptotic protein expression,...
Objective. The mechanism of action asiatic acid (AA) on alcoholic steatohepatitis (ASH) was investigated using network pharmacology and experiments. Methods. Through data retrieval, construction, enrichment analysis, the potential AA in treatment explored. Animal cell models were established this study. Model. mouse model divided into six groups: normal group; low, medium, high silibinin-positive group. Cell An vitro inflammatory RAW264.7 cells by alcohol stimulation. Results. Compared with...
Eleutherosides are important active ingredients of Acanthopanax senticosus, the method for purification eleutherosides has attracted much attention. In this article, a by macroporous resin and anti-inflammatory antioxidant activity elution fractions from senticosus extract investigated. Choosing syringin eleutheroside E as an indication eleutherosides, adsorption characteristics parameters were investigated various types resins. The results show HPD100 provides higher desorption capacity...
COVID-19 is still soaring, and the new delta variant on rise spreading around world.We conducted a patent analysis to better understand therapeutic strategy developed for antivirals available disorders of respiratory system.European granted patents filed from January 2002 June 2021 were analyzed. We used combination International classification (IPC) "A61p31/12" "A61p11/00" search relevant documents.Our study showed R&D antiviral drugs system be decreasing over past 20 years. Chemical...
Abstract The prevailing education management systems in colleges and universities are antiquated, adversely impacting not only the administrative efficiency but also formulation of faculty teaching plans class schedules, as well student electives credit accrual. This paper presents an innovation optimization existing system, wherein processes categorized into seven distinct modules. It delineates flow integration heterogeneous data sources within leveraging database technology foundational...
Background . Wedelolactone (WEL) has demonstrated anti‐inflammatory properties. However, the therapeutic effect and underlying mechanisms of WEL against alcoholic steatohepatitis (ASH) remain unclear. This study aimed to investigate these aspects using animal cell models. Methods Results The animals were categorized into Pair‐fed, ethanol‐fed, ethanol + low‐dose WEL, high‐dose groups. serum levels tumor necrosis factor‐ α (TNF‐ ), interleukin (IL)‐1 β , IL‐6 in group exhibited a...