A5089330168- Zebrafish Biomedical Research Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Adipose Tissue and Metabolism
- Cancer, Hypoxia, and Metabolism
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Eicosanoids and Hypertension Pharmacology
- Mitochondrial Function and Pathology
- RNA Interference and Gene Delivery
- Peroxisome Proliferator-Activated Receptors
- Signaling Pathways in Disease
- Histone Deacetylase Inhibitors Research
- Inflammasome and immune disorders
- Stress Responses and Cortisol
- Lipid metabolism and biosynthesis
- Extracellular vesicles in disease
- Adenosine and Purinergic Signaling
- Tryptophan and brain disorders
Academy of Scientific and Innovative Research
2019-2024
Indian Institute of Chemical Technology
2013-2022
Brown University
2022
Anxiety and depression are major chronic mood disorders, the etiopathology for each appears to be repeated exposure diverse unpredictable stress factors. Most of studies on anxiety related disorders performed in rodents, a good model is (CUS). In this study, we have attempted understand molecular basis neuroglial behavioral changes underlying CUS-induced simplest vertebrate model, zebrafish, Danio rerio. Zebrafish were subjected CUS paradigm which two different stressors used daily 15 days,...
Neuritogenesis, a complex process of the sprouting neurites, plays vital role in structural and functional restoration cerebral ischemia-injured neuronal tissue. Practically, there is no effective long-term treatment strategy for ischemia clinical practice to date due several limitations conventional therapies, facilitating urgency develop new alternative therapeutic approaches. Herein, first time we report that pro-angiogenic nanomaterials, zinc oxide nanoflowers (ZONF), exhibit...
Abstract In search for drugs to treat neuropsychiatric disorders wherein neurotrophic and neurogenic properties are affected, two neurotrophically active small molecules specially crafted following natural product leads based on 2-oxa-spiro[5.5]-undecane scaffold, have been thoroughly evaluated their neurotrophic, neuroprotective potential in ex vivo primary culture zebrafish mouse models. The outcome of investigations suggest that one these is more than while the other former exhibits...
Abstract Following our recent discovery of a new scaffold exhibiting significant neurotrophic and neurogenic activities, structurally tweaked analogue, embodying 2-oxa-spiro [5.4]decane framework, has been conceptualised found to be more potent versatile. It exhibits enhanced action in vitro , ex vivo models also shows robust neuroprotection mouse acute cerebral stroke model. The observed attributes are traceable the predominant activation TrkB-PI3K-AKT-CREB pathway. In addition, it...
Brown adipose tissue (BAT) is a specialized metabolic organ responsible for non-shivering thermogenesis. Recently, its activity has been shown to be critical in systemic health through utilization and consumption of macronutrients. In the face energetically demanding states, flexibility coordination nutrient partitioning requisite survival. this study, we elucidate BAT's differential transcriptional adaptations response multiple challenges demonstrate context-dependent prioritization lipid,...
Understanding the molecular basis of sex differences in neural response to acute hypoxic insult has profound implications for effective prevention and treatment ischemic stroke. Global hypoxic-ischemic induced damage been studied recently under well-controlled, non-invasive, reproducible conditions using a zebrafish model. Our earlier report on difference global hypoxia-induced recovery prompted us conduct comprehensive study mechanisms underlying recovery. An omics approach studying...
Chronic hypoxic exposure triggers the onset and progression of cognitive dysfunction; however, mechanisms underlying chronic hypoxia-induced neuroinflammation its contribution to dysfunction remain poorly understood. Although inflammation hypoxia are interdependent, numerous recent studies have linked development various human diseases inflammation. In this study, we focused on NLRP3 inflammasome with novel analogues cytokine release inhibitory drug 3 (CRID3), a class small molecule...
ABSTRACT Understanding the molecular basis of sex differences in neural response to acute hypoxic insult has profound implications for effective prevention and treatment ischemic stroke. Global hypoxic-ischemic induced damage been studied recently under well-controlled, non-invasive, reproducible conditions using zebrafish model. Our earlier report on difference global hypoxia recovery prompted us comprehensive study mechanisms underlying recovery. An omics approach studying quantitative...
ABSTRACT Hypoxia, the major cause of ischemia, leads to debilitating disease in infants via birth asphyxia and cerebral palsy, whereas adults heart attack stroke. A widespread, natural protective phenomenon termed ‘Hypoxic Preconditioning’ occurs when prior exposures hypoxia eventually results robust resistance. Accordingly, we have developed a novel model sex-specific hypoxic preconditioning adult zebrafish mimic tolerance mini stroke(s) human, which appears protect against severe damage...