A5033662452- Synthetic Organic Chemistry Methods
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Chemical synthesis and alkaloids
- Carbohydrate Chemistry and Synthesis
- Chemical Synthesis and Reactions
- Asymmetric Synthesis and Catalysis
- Marine Sponges and Natural Products
- Microbial Natural Products and Biosynthesis
- Chemical Synthesis and Analysis
- Catalytic Alkyne Reactions
- Catalytic C–H Functionalization Methods
- Oxidative Organic Chemistry Reactions
- Innovative Microfluidic and Catalytic Techniques Innovation
- Sulfur-Based Synthesis Techniques
- Synthesis and Catalytic Reactions
- Traditional and Medicinal Uses of Annonaceae
- Multicomponent Synthesis of Heterocycles
- Synthesis and Biological Evaluation
- Synthesis and biological activity
- Asymmetric Hydrogenation and Catalysis
- Alkaloids: synthesis and pharmacology
- Sesquiterpenes and Asteraceae Studies
- Cyclization and Aryne Chemistry
- Axial and Atropisomeric Chirality Synthesis
Indian Institute of Chemical Technology
2016-2025
Academy of Scientific and Innovative Research
2016-2025
Defence Food Research Laboratory
2024
Royal Society of Chemistry
2023
Cambridge Consultants (United Kingdom)
2023
University of Hyderabad
2015-2020
Division of Chemistry
2016
Council of Scientific and Industrial Research
2010
Université de Rennes
2009
Centre National de la Recherche Scientifique
2009
A general approach involving the insertion of in situ generated aryne into C–C bond cyclic 1,3-diketones for rapidly assembling functionalized benzo-fused medium ring carbocycles is delineated. The efficacy methodology has been demonstrated through a concise total synthesis pentacyclic natural product radermachol.
A new, one-pot domino benzannulation reaction between indole-3-ynones and various nitromethane derivatives has been explored for a general entry to diversely functionalized carbazole frameworks (28 examples). The scope of this new extended variants like 2-chloroindole-3-ynones eventuate in chemo-differentiated 1,2,3,4-tetrasubstituted carbazoles with retention the nitro group. efficacy strategy demonstrated through concise total synthesis natural products, viz. carbazomycin A, calothrixin B,...
Abstract A one‐pot, transition‐metal‐free, domino Michael/S N Ar protocol of general applicability has been devised for the regioselective synthesis polyfunctional naphthalenes by employing nitromethane and ortho ‐haloaryl ynones. Utilization as a one carbon carbanion source that is incorporated into variety ynones, ends up an aromatic nitro substituent. The application this process towards total polycyclic alkaloid macarpine demonstrate efficacy methodology. conceptually simple approach to...
A linear 10-step approach for the stereoselective total synthesis of (3S,5R,6S)-6-isopropyl-3,5-dimethyltetrahydro-2H-pyran-2-one, sex pheromone component Macrocentrus grandii is presented. The key steps involve an enantioselective cross Aldol reaction between isobutyraldehyde and propionaldehyde, a chiral auxiliary mediated diastereoselective methylation reaction, chemoselective reduction α,β-unsaturated ester oxidation to get lactone. similar strategy has been applied prelactone B.
A flexible, regioselective, benzannulation strategy toward multifunctional carbazoles from 2-(2-oxo-2-arylethyl)indole-3-carbaldehydes, employing either ynones or alkynoates as reaction partners, has been envisaged and implemented. This enabling access to variegated in one-flask operation leads strategic substituent diversification via partner variation. The efficacy applications of this methodology are demonstrated through 23 examples concise syntheses bioactive clauolenzole A, calothrixin...
A new general strategy for accessing pyrano[3,2-b]indol-2-ones, a promising fused hybrid heterocyclic system, has been devised from o-nitroynones and β-ketoesters through one-flask cascade process involving tandem Michael addition, intramolecular cyclization, Cadogan-Sundberg reductive cyclization. The utility of this approach further amplified by leveraging the cycloaddition proclivity α-pyrone moiety in pyrano[3,2-b]indol-2-ones toward concise entry to carbazoles. Illustrative synthesis...
ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTFormal Total Synthesis of Cyanolide ASrihari Pabbaraja*, K. Satyanarayana, B. Ganganna, and J. S. YadavView Author Information Organic Division-I, Indian Institute Chemical Technology, CSIR, Hyderabad -500607, India[email protected]Cite this: Org. Chem. 2011, 76, 6, 1922–1925Publication Date (Web):January 31, 2011Publication History Received4 December 2010Published online31 January 2011Published inissue 18 March...
Abstract The stereoselective total syntheses of (+)‐aspergillide B and (+)‐7‐epi‐aspergillide A were achieved. key reactions include Noyori's asymmetric transfer hydrogenation, an Achmatowicz rearrangement, a Ferrier‐type alkynylation, hydrosilylation–protodesilylation, CBS (Corey–Bakshi–Shibata) oxazaborolidine reduction, Yamaguchi macrolactonization, Mitsunobu macrolactonization.
An aryne insertion cascade reaction on oxindoles has been observed and constitutes a convenient "one pot" preparation of bioactive di- triarylated in good yields under mild conditions. A temperature controlled "reaction switch" enables ready access to dibenzo[b,e]azepin-6-one derivatives employing the same regime. This tactic extended short synthesis potent antiulcer agent darenzepine.
The stereoselective synthesis of C1–C17 fragment salinomycin is achieved. strategy employs a desymmetrization approach and utilizes an intramolecular oxetane opening reaction with O-nucleophile to result in the tetrahydropyran skeleton as key step.
A “product control via substrate design” strategy has been conceptualized and implemented to harness the potential of aryne activated alkyne insertions into oxindoles readily efficiently furnish pharmacophoric indano- cyclopentannulated spirooxindole scaffolds in an operationally straightforward, one-pot, transition-metal-free protocol.
An efficient one-pot synthesis of 4-(1H)-quinolones through an orthogonal engagement diverse o-haloaryl ynones with ammonia in the presence Cu(I), involving tandem Michael addition and ArCsp2-N coupling, is presented. The substrate scope this convenient protocol, wherein ammonium carbonate acts as both situ source a base toward 2-substituted 4-(1H)-quinolones, has been mapped its efficacy validated concise total bioactive natural products pseudanes (IV, VII, VIII, XII), graveoline,...
The discovery of reaction regime controlled product diversification in a one-pot between diynones and dimethyl-1,3-acetonedicarboxylate (DMAD) to selectively furnish either functionally unique pentasubstituted o-alkynylbenzoates or fully substituted furan-3(2H)-ones is delineated. potential these two versatile platforms enter new utilitarian chemical space has also been explored.
Abstract A facile approach to the total synthesis of both enantiomers 14‐membered macrolactone aspergillide C is described. The strategy employed was also utilized for C4‐epimers C. key reactions include Sharpless kinetic resolution, Achmatowicz reaction, Ferrier type alkynylation, hydrosilylation‐protodesilylation, Corey–Bakshi–Shibata (CBS) mediated reduction, and Yamaguchi macrolactonization.