A5087189865- Synthesis and biological activity
- Click Chemistry and Applications
- Cancer therapeutics and mechanisms
- Synthesis and Biological Evaluation
- Synthesis and Characterization of Heterocyclic Compounds
- Tuberculosis Research and Epidemiology
- Neurogenetic and Muscular Disorders Research
- Quinazolinone synthesis and applications
- Multicomponent Synthesis of Heterocycles
- Mast cells and histamine
- Signaling Pathways in Disease
- Obstructive Sleep Apnea Research
- Cardiac Structural Anomalies and Repair
- RNA modifications and cancer
- Phenothiazines and Benzothiazines Synthesis and Activities
- HIV/AIDS drug development and treatment
- Cancer-related gene regulation
- Sulfur Compounds in Biology
- Mycobacterium research and diagnosis
Soochow University
2019-2022
Indian Institute of Chemical Technology
2019
National Institute of Technology Karnataka
2015-2016
Abstract Survival of motor neuron (SMN) functions in diverse biological pathways via recognition symmetric dimethylarginine (Rme2s) on proteins by its Tudor domain, and deficiency SMN leads to spinal muscular atrophy. Here we report a potent selective antagonist with 4-iminopyridine scaffold targeting the domain SMN. Our structural mutagenesis studies indicate that both aromatic ring imino groups compound 1 contribute binding Various on-target engagement assays support specifically...
The anti-TB activity of new thiazole–imidazo[2,1-<italic>b</italic>][1,3,4]thiadiazoles, which are synthesized <italic>via</italic> one-pot synthesis, is comparable with that standard drugs.
The hydrolysis of carbonyl sulfide (COS) to form H2S by carbonic anhydrase has been demonstrated be a viable strategy deliver in biological system. Herein, we describe N-dithiasuccinoyl amines as thiol-triggered COS/H2S donors. Notably, thiol species especially GSH and homocysteine can trigger the release both COS directly from several specific analogues via an unexpected mechanism. Importantly, two representative Dts-1 Dts-5 show intracellular release, imparts potent anti-inflammatory...
The article describes the design, synthesis, and characterization of a new series 8‐trifluoromethylquinoline substituted pyrazole‐3‐carboxamides ( 9a , 9b 9c 9d 9e 9f 9g 9h 9i 9j 9k 9l 9m 9n 9o 9p 9q 9r 9s 9t ) derived from different primary secondary amines. intermediate target compounds were characterized using spectroscopic methods. structures 7 molecule evidenced by single crystal X‐ray study. All synthesized three intermediates 6 8 screened for their in vitro antitubercular activity...
Abstract Survival of motor neuron (SMN), a Tudor-domain-containing protein, plays an important role in diverse biological pathways via recognition symmetrically dimethylated arginine (Rme2s) on proteins by its Tudor domain, and deficiency SMN leads to the degenerative disease spinal muscular atrophy (SMA). Here we report potent selective antagonist with 4-iminopyridine scaffold targeting domain SMN. Our structural mutagenesis studies indicate that sandwich stacking interactions compound 1...
Abstract Title compounds (III) are synthesized via one‐pot click chemistry protocol.