A5020760027- Synthetic Organic Chemistry Methods
- Marine Sponges and Natural Products
- Chemical synthesis and alkaloids
- Microbial Natural Products and Biosynthesis
- Catalytic C–H Functionalization Methods
- Cyclopropane Reaction Mechanisms
- Chemical Synthesis and Analysis
Indian Institute of Chemical Technology
2018-2025
Academy of Scientific and Innovative Research
2018-2025
University of Minnesota
2025
A linear 10-step approach for the stereoselective total synthesis of (3S,5R,6S)-6-isopropyl-3,5-dimethyltetrahydro-2H-pyran-2-one, sex pheromone component Macrocentrus grandii is presented. The key steps involve an enantioselective cross Aldol reaction between isobutyraldehyde and propionaldehyde, a chiral auxiliary mediated diastereoselective methylation reaction, chemoselective reduction α,β-unsaturated ester oxidation to get lactone. similar strategy has been applied prelactone B.
The stereoselective total synthesis of the non‐contiguous polypropionate dolabriferol has been accomplished in 17 steps, by an approach that is both divergent and convergent. key reactions involved are enantioselective cross‐aldol coupling, aldol dimerisation propionaldehyde, Sharpless asymmetric epoxidation, regioselective epoxide opening Yamaguchi esterification. effects protecting groups on alcohol substrate differential reactivity esterification were noteworthy.
A novel approach to build 2-spiropiperidine moieties starting from dihydropyridones was developed. The triflic anhydride-promoted conjugate addition of allyltributylstannane onto allowed for the formation gem bis-alkenyl intermediates that were converted corresponding spirocarbocycles with excellent yields via ring closing metathesis. vinyl triflate group generated on these 2-spiro-dihydropyridine could be successfully used as a chemical expansion vector further transformations namely...