A5085821052- Immune Cell Function and Interaction
- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- Cancer, Lipids, and Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Chemokine receptors and signaling
- Angiogenesis and VEGF in Cancer
- Metabolism, Diabetes, and Cancer
- Galectins and Cancer Biology
- Cancer Cells and Metastasis
- Cytokine Signaling Pathways and Interactions
- Cancer-related molecular mechanisms research
- Cell Adhesion Molecules Research
- Caveolin-1 and cellular processes
Bose Institute
2018-2024
Infiltrating T-regulatory cells in the tumor microenvironment is a key impediment to immunotherapy and linked poor prognosis. We found that tumor-infiltrating Tregs express higher expression of chemokine receptor CCR4 than peripheral breast cancer patients. CCL22 CCL17 are released by tumor-associated macrophages, attracting + site. The Treg lineage-specific transcription factor FOXP3 changes promoter epigenetically conjunction with HAT1 provide space for binding activation gene. To increase...
Cancer stem cells (CSCs) are a small subpopulation of that drive the formation and progression tumors. However, during tumor initiation, how CSCs communicate with neighbouring immune to overcome powerful surveillance barrier in order form, spread, maintain tumor, remains poorly understood. It is, therefore, absolutely necessary understand number tumor-initiating (TICs) survive attack (a) “elimination phase” “tumor immune-editing”, (b) establishment regional or distant after metastasis, (c)...
For more than a decade, the nuclear factor kappa-B (NFκB) family and their signaling pathways have proved crucial to immune system's functioning. According research, this is implicated in almost every system event, including cell development function, activation, pathogen-activated death. A considerable body of evidence suggests idea that, addition being possible transcription factor, it plays very significant role establishment inflammation-associated immunological responses host cells....
The host immune system is adapted in a variety of ways by tumour microenvironment and growing interacts to promote escape. One these adaptations manipulating the metabolic processes cells microenvironment. aggressively utilise glucose, its primary energy source available site, produce lactate Warburg effect. In such hostile environment, tumour-infiltrating are unable survive metabolically. Tumour-infiltrating CD4
The tumor microenvironment is composed of a diverse milieu cells such as the stromal cells, various types immune well neoplastic cells. Substantial research in last few decades has provided detailed picture nature and content microenvironment. Apart from composition, recent focus been on altered state metabolism seen Cancer show increased uptake available nutrients, they are also highly active generating metabolic by-products, which creates unique Such aggressive cancer affects viability...