A5090802552- Crystallization and Solubility Studies
- Molecular Sensors and Ion Detection
- X-ray Diffraction in Crystallography
- Sperm and Testicular Function
- Cell death mechanisms and regulation
- Metal-Organic Frameworks: Synthesis and Applications
- Luminescence and Fluorescent Materials
- Metal complexes synthesis and properties
- Reproductive Biology and Fertility
- Synthesis and biological activity
- Sulfur Compounds in Biology
- Autophagy in Disease and Therapy
- RNA Interference and Gene Delivery
- Parasitic Diseases Research and Treatment
- Genomics, phytochemicals, and oxidative stress
- Curcumin's Biomedical Applications
- Research on Leishmaniasis Studies
- Nanoparticle-Based Drug Delivery
- Immune Cell Function and Interaction
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- MicroRNA in disease regulation
- Crystal structures of chemical compounds
- RNA modifications and cancer
- Exercise and Physiological Responses
Bose Institute
2016-2025
Centenary Institute
2021
Jadavpur University
2021
Institute of Molecular Medicine
2006-2017
West Bengal University of Animal and Fishery Sciences
2003-2010
Saha Institute of Nuclear Physics
2010
Texas Tech University Health Sciences Center
2008
Institute on Aging
2008
Texas Tech University
2008
Nepal Medical College Teaching Hospital
2008
Inorganic arsenic is a major water pollutant and known human carcinogen that has suppressive influence on spermatogenesis androgenesis in male reproductive system. However, the actual molecular events resulting dysfunctions from exposure to remain unclear. In this context, we evaluated mode of action chronic oral sodium arsenite hypothalamo-pituitary- testicular activities mature albino rats.The effect (5 mg/kg body weight/day) via drinking without or with hCG I.U./kg oestradiol (25...
Mycobacterium tuberculosis (M.tb.) replicates in host macrophages to cause tuberculosis. We have investigated the role of miRNAs M.tb.-infected murine RAW264.7 cells and bone marrow-derived (BMDMs), focusing on miR-155, most highly upregulated miRNA. observed that miR-155 upregulation is directly linked attenuation expression BTB CNC homology 1 (Bach1) SH2-containing inositol 5'-phosphatase (SHIP1). Bach1 a transcriptional repressor haem oxygenase-1 (HO-1), whereas SHIP1 inhibits activation...
For efficient clearance of Mycobacterium tuberculosis (Mtb), macrophages tilt towards M1 polarization leading to the activation transcription factors associated with production antibacterial effector molecules such as nitric oxide (NO) and proinflammatory cytokines interleukin 1 β (IL-1β) tumor necrosis factor α (TNF-α). At same time, resolution inflammation is M2 increased arginase IL-10. The transcriptional post-transcriptional mechanisms that govern balance between polarization,...
Recurrent pregnancy loss (RPL) in polycystic ovary syndrome (PCOS), which occurs ∼50% of total pregnancies is a frequent obstetric complication. Among the several hypotheses, insulin resistance (IR), obesity and hyperhomocysteinemia (HHcy) play significant role/s RPL. This study was conducted to assess link between elevated levels homocysteine IR PCOS-associated women with RPL Kolkata, India. A retrospective one hundred twenty six PCOS (<30 years) who experienced two or more spontaneous...
Autophagy plays a crucial role in the control of bacterial burden during Mycobacterium tuberculosis infection. MicroRNAs (miRNAs) are small non-coding RNAs that regulate immune signalling and inflammation response to challenge by pathogens. Appreciating potential host-directed therapies designed autophagy mycobacterial infection, we focused on miRNAs regulating M. tuberculosis-induced macrophages. Here, demonstrate infection leads downregulation miR-17 concomitant upregulation its targets...
Infiltrating T-regulatory cells in the tumor microenvironment is a key impediment to immunotherapy and linked poor prognosis. We found that tumor-infiltrating Tregs express higher expression of chemokine receptor CCR4 than peripheral breast cancer patients. CCL22 CCL17 are released by tumor-associated macrophages, attracting + site. The Treg lineage-specific transcription factor FOXP3 changes promoter epigenetically conjunction with HAT1 provide space for binding activation gene. To increase...
The present study was done to evaluate the pituitary-testicular activities of rats subjected chronic nicotine treatment. testicular key androgenic enzymes activities, plasma and intratesticular testosterone (ITT) concentrations, concentration gonadotropin were significantly reduced by treatment along with decreased sperm counts disruption spermatogenesis indicated significant reduction in number different generations germ cells at stage VII cycle increased head abnormalities. Western blot...
Eukaryotic DNA is compacted in the form of chromatin, a complex with histones and other non-histone proteins. The intimate association chromatin raises possibility that DNA-interactive small molecules may bind to chromatin-associated proteins such as histones. Employing biophysical biochemical techniques we have characterized interaction classical intercalator, ethidium bromide (EB) its structural analogue propidium iodide (PI) hierarchical genomic components: long chromatosome, core octamer...
Curcumin has shown therapeutic activity against triple-negative breast cancer (TNBC) cells, but it shows low efficacy and bioavailability when administered as a free drug.
Breast cancer is the most common in women globally, and diagnosing it early finding potential drug candidates against multi-drug resistant metastatic breast cancers provide possibilities of better treatment extending life.The current study aimed to evaluate synergistic anti-metastatic activity Curcumin (Cur) Paclitaxel (Pacli) individually, combination Curcumin-Paclitaxel (CP), also conjugation with gold nanoparticles (AuNP-Curcumin (Au-C), AuNP-Paclitaxel (Au-P), AuNP-Curcumin-Paclitaxel...
A 3D coordination polymer of Mn(II), [Mn2(aisp)3(pcih)2(solvent)]n(CP1) (pcih = pyridine-4-carboxaldehyde isonicotinoyl hydrazine and H2aisp 5-aminoisophthalic acid), was constructed by doubly heterobridging ligands characterized single-crystal X-ray diffraction measurements. The noncovalent forces (H-bonding, π···π interactions) bring robustness stability (thermal chemical) to the framework. optical band gap CP1 obtained from Tauc's plot (2.98 eV) is comparable with DFT computation value...
Although it has been well established that spermatogenic cells undergo apoptosis when treated with ethanol, the molecular mechanisms behind remain to be investigated. Adult male mice were given intra-peritoneal injection (IP) of ethanol at a dose 3 g (15%, v/v) per kg body weight day during period 14 days. Testicular androgenesis and apoptotic germ cell death, along different interrelated proteins expression, evaluated. Ethanol treatment induced death decrease in plasma intra-testicular...
Calcium chloride solution is an established injectable sterilant in dogs and other mammals. With cat populations a continuing problem, we sought to explore its first use cats. Six cats per group were injected with 5%, 10% or 20% calcium dihydrate saline lignocaine hydrochloride, local anaesthetic. At the 60th day post-injection, testes collected showed complete testicular necrosis replacement by fibrous tissue; very low sperm counts; reduction of serum testosterone at least 70% dose....
The active fraction and/or compounds of Calendula officinalis responsible for wound healing are not known yet. In this work we studied the molecular target C. hydroethanol extract (CEE) and its (water extract, WCEE) on primary human dermal fibroblasts (HDF). vivo, CEE or WCEE were topically applied excisional wounds BALB/c mice rate contraction immunohistological studies carried out. We found that only significantly stimulated proliferation as well migration HDF cells. Also they up-regulate...
B(a)P (Benzo(a)pyrene) is an environmental toxicant that induces male germ cell apoptosis. Curcumin and resveratrol are phytochemicals with cytoprotective anti-oxidative properties. At the same time also a natural Aryl hydrocarbon Receptor (AhR) antagonist. Our present study in isolated testicular population from adult Wistar rats, highlighted synergistic protective effect of curcumin against induced p53 mediated Curcumin-resveratrol significantly prevented decrease sperm count motility, as...
Abstract Resveratrol, a trans -stilbene polyphenolic compound and its synthetic analogs are widely used bioactive molecules due to their remarkable chemo-preventive potential. Here, we have identified novel compound, Z-DAN-11 ((Z)-3-(3, 4-dimethoxyphenyl)-2-(3, 4, 5-trimethoxyphenyl) acrylonitrile) which shows efficacy in blocking tumor growth progression both vitro vivo. inhibits proliferation of cancer cells through microtubule depolymerization that induced G2/M arrest consequently leads...
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Nowadays, the search for new chemotherapeutic agents with low toxicity and high selectivity is a major concern. In this paper, we report synthesis characterization of hybrid thiosemicarbazone/hydrazone ligand in its neutral form (L1H2) as chloride salt ([L1H3]Cl)-, three diorganotin (IV) complexes, one complex Sn (IV). The compounds have been fully characterized by IR, mass spectra, 1H, 13C, 119Sn NMR, CP/MAS single crystal X-ray diffraction. organotin empirical formula [SnR2L1] (R = Me, Bu,...
During the aging process of males, testosterone biosynthesis declines in testicular Leydig cells resulting decreases various physiological functions. To explore possibility delaying decline using food supplements, we have studied steroidogenic effects a natural flavonoid, chrysin, mouse cells. Chrysin dramatically increased cyclic AMP (cAMP)-induced steroidogenesis MA-10 tumor This result was confirmed isolated from testes. The effect chrysin is not associated with an increase expression...