A5077577268- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Estrogen and related hormone effects
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Lipid Membrane Structure and Behavior
- SARS-CoV-2 and COVID-19 Research
- CRISPR and Genetic Engineering
- Advanced Nanomaterials in Catalysis
- MicroRNA in disease regulation
- Virus-based gene therapy research
- Curcumin's Biomedical Applications
- Cancer, Hypoxia, and Metabolism
- Bioactive Compounds and Antitumor Agents
- Cancer Cells and Metastasis
- Cancer, Stress, Anesthesia, and Immune Response
- Advanced Breast Cancer Therapies
- Psoriasis: Treatment and Pathogenesis
- Nigella sativa pharmacological applications
- Bacteriophages and microbial interactions
- Signaling Pathways in Disease
- Bacterial biofilms and quorum sensing
- Histone Deacetylase Inhibitors Research
- RNA regulation and disease
- Coconut Research and Applications
Indian Institute of Chemical Technology
2015-2024
Academy of Scientific and Innovative Research
2015-2024
Mayo Clinic in Florida
2021-2024
Jacksonville College
2021-2024
Mayo Clinic
2024
WinnMed
2023
University of Hyderabad
2016-2018
Breast cancer is the most common in women globally, and diagnosing it early finding potential drug candidates against multi-drug resistant metastatic breast cancers provide possibilities of better treatment extending life.The current study aimed to evaluate synergistic anti-metastatic activity Curcumin (Cur) Paclitaxel (Pacli) individually, combination Curcumin-Paclitaxel (CP), also conjugation with gold nanoparticles (AuNP-Curcumin (Au-C), AuNP-Paclitaxel (Au-P), AuNP-Curcumin-Paclitaxel...
Silver nanoparticles were green synthesized (Ag-PTs) employing the crude extract of Padina tetrastromatica, a marine alga, and their anticancer safety profile compared with those chemically silver (Ag-NPs) by in vitro vivo models. Ag-PT exhibited potent cytotoxicity against B16-F10 (IC50 = 3.29), MCF-7 4.36), HEPG2 =3.89), HeLa 4.97) cancer cell lines, whereas they lower toxicity on normal CHO-K1 cells 5.16). The activity Ag-PTs is due to liberation ions from nanoparticles. Increased ion...
Cationic lipid-guided nucleic acid delivery holds great promise in gene therapy and genome-editing applications for treating genetic diseases. However, the major challenge lies achieving therapeutically relevant efficiencies. Prior findings, including our own, demonstrated that asymmetry hydrophobic core of cationic lipids imparted superior transfection To this end, we have developed a lipid nanocarrier system with an asymmetric (PS-Lips) derived from mixture fatty acids food-grade...
Cationic lipids have been extensively studied for their ability to complex with nucleic acids condense and consequently deliver them into the cells.
Long-term application of topical therapeutics for psoriasis has a plethora side effects. Additionally, skin-permeating agents used in their formulations deeper dermal delivery damage the skin. To address these limitations, we developed novel lithocholic acid analogues that could form lipid nanoparticles (nano-LCs) spontaneously aqueous milieu, permeate through skin, penetrate layers, and exert anti-inflammatory effects against psoriasis-like chronic skin inflammations. Prior findings...
Endosomal escape is one of the barriers for efficient liposomal gene delivery.
Cationic lipids are well-known excipients for nanometric liposomal gene delivery systems. However, because of the suspected, collateral toxicity in normal cells, use cationic treatment human tumor is largely limited. Recently, we developed a glucocorticoid receptor (GR)-targeted liposomal, anticancer system (DXE nano-lipoplex), which carried lipid saturated twin aliphatic chains. It exhibited efficient anti-tumor effect aggressive and drug-resistant models. Toward exploring lipoplex's...
High mortality rate in colon cancer patients is often attributed to late diagnosis. To overcome the conventional chemotherapy associated challenges, chemotherapeutic drugs (single or combination) genetic are delivered using ligand-modified delivery systems that selectively target over expressed receptors particular act abnormally cells. In current investigation, first we assessed anti-colon effect of a cationic estrogenic molecule, ESC8 which was earlier shown against estrogen receptor (ER)...
Due to the fast mutating nature of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), development novel therapeutics, vaccines, and evaluating efficacies existing one’s against mutated strains is critical for containing virus. Pseudotyped SARS-CoV-2 viruses are proven be instrumental in efficiencies owing their ease application safety when compared handling live However, a comprehensive protocol that includes selecting transfection reagents, validating different packaging systems...
Function of steroid hormone oestrogen that transactivates receptor (ER) is expressed in multiple organs. Except for malignancies gynaecological organs, ER remains largely unutilised as a target to treat cancers ER-expressing brain, prostate, skin etc. We have previously developed targeting cationic lipid molecule (ES-C10), which showed targeted killing + breast and cancer cells. In this study, we explored the ability ES-C10 ligand well its additive effect (if any), when incorporated two...
Delivering nucleic acids into the endothelium has great potential in treating vascular diseases. However, endothelial cells, which line vasculature, are considered as sensitive nature and hard to transfect. Low transfection efficacies cells limit their therapeutic applications. Towards improving efficiency, we made an effort understand internalization of lipoplexes is first most critical step acid transfections. In this study, demonstrated that transient modulation caveolae/lipid rafts...
To assess the chemo-immunomodulatory effects of doxorubicin-loaded cerium oxide nanoparticles coated with oleyl amine-linked cyclic RGDfK peptide (CeNP+Dox+RGD) to target both gliomas and its tumor microenvironment (TME) via integrin receptors.
Hydrocortisone, a natural glucocorticoid secreted by adrenal and extra-adrenal tissues, locally governs the transcription of genes involved in inflammation, immune response, metabolism, energy homeostasis via binding to its cognate receptor (GR). In this study, we show that modified hydrocortisone (HC16), cancer-selective cytotoxic molecule, showed synergism combination with drugs like Doxorubicin docetaxel, self-assembled into vesicles, entrapped docetaxel complexed anti-cancer plasmid DNA...
Abstract Breast cancer (BC) remains one of the deadliest and frequently diagnosed metastatic cancers worldwide. Cancer stem cells (CSCs) are cell population within tumor niche, having an epithelial to mesenchymal (EMT) transition phenotype, high self‐renewal, vigorous capacity, drug resistance, relapse. Identification targets for induction apoptosis is essential provide novel therapeutic approaches in BC. Our earlier studies showed that Vitamin C induces apoptotic death by losing redox...
Targeted drug delivery remains an active area of investigation in hematologic cancers. We have previously reported on a novel nanoparticle formulation (D1X) that can encapsulate drugs within liposome whose lipid bilayer contains dexamethasone, which serves as targeting ligand for to tumor cells express glucocorticoid receptors. tested the activity D1X-encapsulated bortezomib (D1XB) combination with nutlin (D1XN) B-lymphoma/Waldenstrom macroglobulinemia (WM) cells. WM treated D1XB + D1XN...