Shanooja Shanavas

ORCID: 0000-0003-0820-1651
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About
Contact & Profiles
Research Areas
  • Metal complexes synthesis and properties
  • Cancer Cells and Metastasis
  • Click Chemistry and Applications
  • Cancer, Hypoxia, and Metabolism
  • Synthesis and biological activity
  • Free Radicals and Antioxidants
  • Metabolism, Diabetes, and Cancer
  • Genetic Neurodegenerative Diseases
  • Muscle Physiology and Disorders
  • Ferroptosis and cancer prognosis
  • Bioactive Compounds and Antitumor Agents
  • Cancer Research and Treatments
  • Parkinson's Disease Mechanisms and Treatments
  • Nanocluster Synthesis and Applications
  • Neuroblastoma Research and Treatments
  • Synthesis and Characterization of Heterocyclic Compounds
  • Nanoplatforms for cancer theranostics
  • Ferrocene Chemistry and Applications
  • Genomics, phytochemicals, and oxidative stress
  • Lung Cancer Research Studies
  • Drug Transport and Resistance Mechanisms
  • RNA modifications and cancer
  • Computational Drug Discovery Methods
  • Advanced biosensing and bioanalysis techniques
  • Synthesis of Tetrazole Derivatives

Yenepoya University
2021-2025

The effectiveness of existing systemic and targeted therapies remains limited in triple-negative breast cancer (TNBC) treatment. Much research has been conducted on reactive oxygen species (ROS)-mediated cell death to overcome the shortcomings currently applied chemotherapeutic treatments. Herein, we have developed novel Ru(II)/Ir(III)-mediated triazolylpyridine complexes as ROS inducers. Upon entering TNBC cells, Ru(II) complex effectively accumulated mitochondria triggered creation ROS,...

10.1021/acs.jmedchem.4c02089 article EN Journal of Medicinal Chemistry 2025-02-05

A series of novel Ru(II)/Ir(III)/Re(I)-based organometallic complexes [Ru2L1, Ru2L2, Ir2L1, Ir2L2, Re2L1, and Re2L2] have been synthesized to assess their potency selectivity against multiple cancer cells A549, HCT-116, HCT-116 colon CSCs. The cytotoxic screening the has revealed that complex Ru2L1 Ir2L2 are two proficient among all, but is most potent complex. significant binding constant value was observed for DNA BSA in all complexes. Significant lipophilic properties allow them penetrate...

10.1021/acs.jmedchem.4c00406 article EN Journal of Medicinal Chemistry 2024-05-30

Triple-negative breast cancer (TNBC) is an extremely vicious subtype of human having the worst prognosis along with strong invasive and metastatic competency. Hence, it can easily invade into blood vessels, presently, no targeted therapeutic approach available to annihilate this type cancer. Metal complexes have successfully stepped anticancer research are now being applauded due their potency after discovery cisplatin. Many these metal also well recognized for activity toward As TNBC a very...

10.1021/acsomega.2c08285 article EN cc-by-nc-nd ACS Omega 2023-03-21

Due to a number of unpleasant considerations, marketed drugs have steadily lost their importance in the treatment cancer. In order find viable cancer cell diagnostic agent, we therefore focused on metal complexes that displayed target adequacy, permeability cells, high standard water solubility, cytoselectivity, and luminescent behavior. this aspect, 11-{naphthalen-1-yl} dipyrido [3,2-a:2′,3′-c] phenazine based Ru(II)/Ir(III)/Re(I) been prepared for HCT-116 colorectal stem therapy. Our study...

10.1021/acsabm.2c00556 article EN ACS Applied Bio Materials 2023-01-13

The study investigated the impact of benzodipyridophenazine-based Ru(II) and Ir(III) complexes (Ru1, Ru2, Ir1, Ir2) on their anticancer activity. Metal displayed three significant absorption bands because intra-ligand...

10.1039/d4dt03456b article EN Dalton Transactions 2025-01-01

Mitochondria targeting half-sandwich Iridium( iii )-Cp*-arylimidazophenanthroline complexes have been developed for MDA-MB-468 cell therapy and diagnosis.

10.1039/d2ra01036d article EN cc-by RSC Advances 2022-01-01

Ferroptosis has been recognized as an iron-based nonapoptotic-regulated cell death process. In the quest of resisting unyielding vehemence triple-negative breast cancer (TNBC), herein we have showcased ferroptosis-inducing heteroleptic [LIrcRu], [LIrcIrh], and [LIrcRe] complexes, enabling them to selectively target "sialic acid", overexpressed cell-surface marker. The open-circuit potential (OCP) measurements in live cells revealed specific interaction between TNBC whereas control...

10.1021/acs.langmuir.4c02043 article EN Langmuir 2024-11-18

Abstract Breast cancer (BC) remains one of the deadliest and frequently diagnosed metastatic cancers worldwide. Cancer stem cells (CSCs) are cell population within tumor niche, having an epithelial to mesenchymal (EMT) transition phenotype, high self‐renewal, vigorous capacity, drug resistance, relapse. Identification targets for induction apoptosis is essential provide novel therapeutic approaches in BC. Our earlier studies showed that Vitamin C induces apoptotic death by losing redox...

10.1002/cbin.11978 article EN Cell Biology International 2022-12-27

Herein, we have introduced a series of iridium(III)-Cp*-(imidazo[4,5-f][1,10]phenanthrolin-2-yl)phenol complexes via convenient synthetic methodology, which act as hypoxia active and glutathione-resistant anticancer metallotherapeutics. The [IrIII(Cp*)(L5)(Cl)](PF6) (IrL5) complex exhibited the best cytoselectivity, GSH resistance effectivity in HeLa Caco-2 cells among synthesized complexes. IrL5 also highly cytotoxic effects on HCT-116 CSC cell line. This was localized mitochondria...

10.1039/d2dt00168c article EN Dalton Transactions 2022-01-01

Cancer stem cells (CSCs) are implicated as the underlying cause of tumor recurrence due to their refractoriness conventional therapies. Targeting CSCs through novel approaches can hinder survival and proliferation, potentially reducing challenges associated with relapse. Our previous study demonstrated that colorectal cancer (CR-CSCs) showed sensitivity Vitamin C (Vit C), displaying a dose-responsive effect where low doses (2-10 µM) promoted cell proliferation while high induced death. In...

10.1002/jcb.30686 article EN Journal of Cellular Biochemistry 2024-12-11

Abstract Breast cancer (BC) remains one of the deadliest and frequently diagnosed metastatic cancers worldwide. Cancer stem cells (CSCs) are cell population within tumour niche, having an epithelial to mesenchymal (EMT) transition phenotype, high self-renewal, vigorous capacity, drug resistance, relapse. Identification targets for induction apoptosis is essential provide novel therapeutic approaches in BC. Our earlier studies showed that Vitamin C induces apoptotic death by losing redox...

10.1101/2021.05.21.445099 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2021-05-21
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