A5035182360- Estrogen and related hormone effects
- ATP Synthase and ATPases Research
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Ferrocene Chemistry and Applications
- Heat shock proteins research
- thermodynamics and calorimetric analyses
- Histone Deacetylase Inhibitors Research
- Synthesis and biological activity
- Redox biology and oxidative stress
- Sulfur Compounds in Biology
- Graphene and Nanomaterials Applications
- Cancer, Stress, Anesthesia, and Immune Response
- Advanced biosensing and bioanalysis techniques
Indian Institute of Chemical Technology
2013-2020
Shenzhen University
2018-2019
Realizing the significant roles of vicinal-dithiol proteins (VDPs) in maintaining cellular redox homeostasis and their implication many diseases, we synthesized a smart arsenate based fluorescent probe 1 which can preferentially target mitochondrial membrane-bound vicinal dithiol (VDPs), especially voltage-dependent anion channel (VDAC2). The targetability was demonstrated by vitro studies such as colocalization, stimulated emission depletion (STED) super-resolution imaging, proteomic MS/MS...
Abstract We report a new family of bis‐arylidene oxindole derivatives that show highly selective estrogen receptor (ER)‐mediated anticancer activity at low‐nanomolar concentrations in ER‐positive (ER+) breast cancer cells. In terms cell growth inhibition, IC 50 values for these compounds ER+ cells are two to three orders magnitude lower than ER‐negative (ER−) and non‐cancer comparison with known drugs, least more toxic tamoxifen 1.5–4‐fold 4‐hydroxytamoxifen MCF‐7 These oxindoles inhibit ER...
Hydrocortisone, a natural glucocorticoid secreted by adrenal and extra-adrenal tissues, locally governs the transcription of genes involved in inflammation, immune response, metabolism, energy homeostasis via binding to its cognate receptor (GR). In this study, we show that modified hydrocortisone (HC16), cancer-selective cytotoxic molecule, showed synergism combination with drugs like Doxorubicin docetaxel, self-assembled into vesicles, entrapped docetaxel complexed anti-cancer plasmid DNA...