Silver nanoparticles (AgNPs) derived from natural sources have garnered significant attention due to their unique properties and eco-friendly production methods. With lung cancer remaining a major global health issue, there is continuous need for novel effective therapeutic approaches beyond conventional treatments such as chemotherapy, immunotherapy, targeted therapies.

The evolution of nanotechnology and the production nanomedicine from various sources had proven to be intense value in field biomedicine. smaller size nanoparticles is gaining importance research for treatment diseases. Moreover eco-friendly cost effective. In present study silver were synthesized Carica papaya leaf extract (CPL) characterized their shape using scanning electron microscopy transmission microscopy, respectively. Fourier transform infrared spectroscopy (FTIR), Energy...

Cancer related morbidity and mortality is a major health care concern. Developing potent anti-cancer therapies which are non-toxic, sustainable affordable of alternative medicine. This study was designed to investigate the aqueous natural extracts mixture (NE mix) prepared from common spices turmeric, ginger garlic for its free radical scavenging potential property against human breast cancer cell lines (MCF-7, ZR-75 MDA-MB 231). Qualitative analysis their bioactive constituents were done...

Breast cancer is the most common in women globally, and diagnosing it early finding potential drug candidates against multi-drug resistant metastatic breast cancers provide possibilities of better treatment extending life.The current study aimed to evaluate synergistic anti-metastatic activity Curcumin (Cur) Paclitaxel (Pacli) individually, combination Curcumin-Paclitaxel (CP), also conjugation with gold nanoparticles (AuNP-Curcumin (Au-C), AuNP-Paclitaxel (Au-P), AuNP-Curcumin-Paclitaxel...

Abstract Fluoride induced oxidative stress through depletion in levels of various anti‐oxidants such as glutathione, superoxide dismutase (SOD), fat soluble vitamins (D and E) with increased lipid peroxidation (LPO) fluoride aggravate the damage rodents well humans. Vitamins A, a vitamin possess antioxidant property which plays significant role scavenging free radicals species similar to D E. Vitamin A is involved neural tissue development plasticity. The growing evidence about being...

The present study evaluates the protective role of quercetin against sodium fluoride (NaF) induced neurotoxicity in developing rat brain using biochemical, behavioural and histopathological parameters. Timed pregnant Wistar rats were chosen for they distributed into three groups (group 1: control, group 2: 3: fluoride- quercetin). duration is 53 days (i.e. Gestational post gestational period), where control received normal tap water; Fluoride 20 ppm third both mg through oral gavage....

Development of an in vitro model for assessing the anti-inflammatory efficacies naringin (Nar) and naringenin (NG).To evaluate efficacy natural flavonoids as therapeutic drugs against processes nucleus pulposus (NP) cells using in-vitro in-silico methods.Intervertebral disc (IVD) disease is a common cause low back pain. Chronic inflammation degeneration play significant role its etiopathology. Thus, better understanding agents their IVD pro-inflammatory cytokines expression necessary pain...

Cardiovascular diseases (CVDs) are one of the leading causes global morbidity and mortality. Among these, ischemic heart disease (IHD) or coronary artery (CAD) accounts for major deaths due to CVDs. Several approaches followed treat limited various adverse effects cost treatment. Recently, nanotechnology has revolutionized field biomedical research by introducing technologies improve health care, using a nanomedicine approach. In this context, our group well-established europium hydroxide...

The adenoma-carcinoma sequence in thyroid nodules is an enigmatic phenomenon. Genomics the only definitive modality to resolve this hypothesis. Adenomas and papillary carcinomas tend have mutations RAS highly specific BRAF gene respectively. In context, we set out study prevalence clinical significance of these somatic surgical tissue samples.This retrospective was conducted on surgically managed nodule patients. Institutional ethical committee approval obtained. Diagnosis based biochemical...

Psoriasis is a chronic inflammatory skin disorder characterized by rapid proliferation of keratinocytes and incomplete keratinization. Discovery safer more effective anti-psoriatic drugs remains an area active research at the present time. A431 B16-F10 cell lines were used as in vitro models. In study, we aimed assessing Anti-psoriatic activity aqueous extract Acalypha indica. We analyzed efficiency A. indica leaf inducing death apoptosis these lines. The (Propidium iodide) (Annexin V) was...

Developing an in vitro model for assessing the anti-inflammatory properties of curvularin.

Objective: The study was aimed to assess the anti-oxidative and anti-diabetic efficacy of few dietary supplements such as Artocarpus heterophyllus (Raw Jackfruit), Zea mays (Corn Silk), Syzygium cumini (Black plum), Shilajit asphaltum) in vitro vivo models. phytoextracts were compared with known commercial diabetic drugs (Aminoguanidine, Glibenclamide Insulin) controlling Streptozotocin induced hyperglycemia, advanced glycation end-products (AGEs), hyperlipidemia activation inflammatory...

Anticancer treatment against oral and lung cancers has caught the eye of oncologist researchers worldwide as most common cause deaths in India is due to these strategies employed are not showing any effectiveness neoplastic ability cancers. One reasons for cancer could be because poor prognosis associated therapies. The existing agents being re-evaluated development new mechanisms explored continuously, but it's inadequate offering treatment. Therefore, endeavors anticancer with high...

To induce scoliosis in young female Wistar rats using a noninvasive method and to validate this model.To rat model noninvasively by bracing study the corresponding gene-expression profile spine different organs.Scoliosis involves abnormal lateral curvature of spine, causes which remain unclear. In literature, it is suggested that genetically heterogeneous, as there are multiple factors involved directly or indirectly its pathogenesis. Clinical experimental studies were conducted understand...

Curcumin is a pivotal spice and ayurveda medication mostly used in India other Asian countries. The curcumin been part of people for centuries as detoxificant, pain reliever, anti-inflammatory agent it has also demonstrated to have anti-cancer properties. Fluoride becoming an irreversible environmental pollutant causing various alignments both humans animals on chronic exposure. ameliorative studies developing rats were studied presence against sodium fluoride induced oxidative stress....

The present study reports the protective efficiency of saffron extract against arsenic induced learning impairments and excitotoxicity. efficacy was studied using open field, maze estimating levels glutamate aspartate. experimental rats received 100 mg/kg bw through drinking water protectant at dosage given gavage needle. group receiving showed severe weight loss, dysfunction increased aspartate in hippocampus cerebral cortex. Whereas have shown reduced toxic effects arsenic, which observed...

Low back pain is a frequently encountered issue in pregnant women affecting >50%; incidence of low secondary to lumbar disc herniation pregnancies (1:10000). Cauda equina syndrome from serious complication; delay diagnosis and treatment can be cause chronic disability neurological sequelae. Numerous cases pregnancy have been reported; however, cauda as result rare (2%). Here we are reporting case equine woman at 16-week gestation presented. We present 30-year-old (G3P2L0) gestation,...

Mesenchymal stem cells (MSCs) are multipotent and considered a potential source for tissue organ repair due to their self-renewal, proliferation, differentiation abilities. However, in most cases, MSCs needed be stimulated with external growth factors promote proliferation differentiation. Over the past decade, it has been demonstrated that nanomaterials could facilitate MSC differentiation, excellent efforts carried out investigate possible modulating pattern mechanisms Europium hydroxide...

<h3>Abstract</h3> <h3>Background</h3> Enchondroma protuberans (EP) is rare, benign cartilaginous bone tumor arising from the intramedullary cavity of long bones and usually protrudes beyond cortex with an exophytic growth pattern resembling osteochondroma. This study reports on a rare case EP transverse process D8 vertebra extending to adjacent 7th 8th ribs paraspinal tissues. <h3>Methods</h3> A 45-year-old female patient came in complaints upper back pain radiating up left costal margin for...

Granulicatella species commonly known as nutritionally variant streptococci (NVS) are part of the normal oral flora and found in endocardium, dental plaques, abscesses, endodontic infection. Severe complications may arise due to its ability cause a variety serious infections. The presence spine or surgical site was never noticed reported. Here, we present rare case G. adiacens muscular plane L5–S1 vertebrae which were diagnosed radiologically also microbiologically give appropriate treatment...

Coleus forskohlii (CF) is a well-known medicinally important plant and it has been part of Ayurveda for decades. Forskolin, diterpene active constituent root extract (CFRE). The CFRE used treating various infections chronic diseases. But the never as pesticide. Exorista bombycis (Uzi fly) common pest found to infest Bombyx mori (Silk worm) cause severe loss sericulture farmers or community. Uzi fly targets fifth instar larvae silk worm lay its eggs propagation species. Forskolin were...