A5085298796- SARS-CoV-2 and COVID-19 Research
- Salmonella and Campylobacter epidemiology
- Immune Response and Inflammation
- interferon and immune responses
- vaccines and immunoinformatics approaches
- Influenza Virus Research Studies
- Respiratory viral infections research
- Vector-Borne Animal Diseases
- Animal Disease Management and Epidemiology
- Herpesvirus Infections and Treatments
- Pharmaceutical and Antibiotic Environmental Impacts
- Antibiotic Resistance in Bacteria
- COVID-19 Clinical Research Studies
- Computational Drug Discovery Methods
- Bacteriophages and microbial interactions
- Virology and Viral Diseases
- Immune Cell Function and Interaction
- Helminth infection and control
- Brucella: diagnosis, epidemiology, treatment
- Animal Virus Infections Studies
- Poxvirus research and outbreaks
- Livestock and Poultry Management
- Identification and Quantification in Food
- Healthcare and Venom Research
- Parasitic Infections and Diagnostics
Sylhet Agricultural University
2016-2025
The University of Texas Medical Branch at Galveston
2022-2024
Chungnam National University
2015-2023
Khulna University of Engineering and Technology
2023
Chattogram Veterinary and Animal Sciences University
2020
Sylhet International University
2018
Antimicrobial resistance (AMR) has become an emerging health issue globally, posing a threat to zoonotic pathogens and foodborne diseases. In Bangladesh, the poultry sector supplies majority of demand for animal-source protein. The irrational excessive use antimicrobials (AMU) been observed in sector. development AMR is associated with many factors, including knowledge attitudes farmers. Therefore, reduction requires intervention from all stockholders, farmers who are considered as end users...
ARSs are essential enzymes in translation that link specific amino acids to their cognate tRNAs. In higher eukaryotes, some possess additional, noncanonical functions the regulation of cell metabolism. Here, we report a novel function WRS antiviral defense. is rapidly secreted response viral infection and primes innate immune by inducing secretion proinflammatory cytokines type I IFNs, resulting inhibition virus replication both vitro vivo . Thus, consider be member response. The results...
Current evidence indicates that more than half of all antimicrobials are used in the animal food-producing sector, which is considered a significant risk factor for development, spread, and existence antimicrobial resistance (AMR) pathogens animals, humans, environment. Among other factors, clinical etiology level knowledge, attitudes, practices (KAP) veterinarians thought to be responsible inappropriate prescriptions animal-source protein production sector lower-resource settings like...
Immune activation is essential for lung control of viral and bacterial infection, but an overwhelming inflammatory response often leads to the onset acute respiratory distress syndrome (ARDS). Interleukin-10 (IL-10) plays a crucial role in regulating balance between antimicrobial immunity immunopathology. In current study, we have investigated IL-10 injury (ALI) induced by influenza A virus (IAV) methicillin-resistant Staphylococcus aureus (MRSA) coinfection. This unique coinfection model...
Exposure to influenza A virus (IAV), respiratory syncytial (RSV), and human metapneumovirus (hMPV) is well-known increase the risk of Streptococcus pneumoniae (SPn) pneumonia in humans. Type I interferon (IFN-I) a hallmark response acute viral infections, alveolar macrophages (AMs) constitute first line airway defense against opportunistic bacteria. Our study reveals that virus-induced IFN-I receptor (IFNAR1) signaling directly impairs AM-dependent antibacterial protection. Using Ifnar1...
This study aimed to characterize virulence and antibiotic resistance genes in multidrug-resistant (MDR) extensively drug-resistant (XDR) Escherichia coli Klebsiella pneumoniae isolated from cases of subclinical mastitis (SCM) buffaloes. A cross-sectional was conducted on 1540 quarter milk samples collected 385 Milk were screened using the California Mastitis Test Modified Whiteside Test. Positive underwent bacterial culture, biochemical tests, biofilm detection molecular analysis for...
ABSTRACT Rubicon is part of a Beclin-1-Vps34-containing autophagy complex. induces antimicrobial responses upon Toll-like receptor (TLR) stimulation and functions as feedback inhibitor to prevent unbalanced proinflammatory depending on dectin-1 signaling. However, the role played by during antiviral immune responses, particularly type I interferon (IFN) remains largely unknown. Here, we report that acts negative regulator for virus-triggered IFN Knockdown promoted signaling inhibited virus...
Here, drug repurposing and molecular docking were employed to screen approved MPP inhibitors their derivatives suggest a specific therapeutic agent for the treatment of COVID-19. The against HIV HCV prioritized, while RNA dependent Polymerase (RdRp) inhibitor remdesivir including Favipiravir, alpha-ketoamide studied as control groups. target surface hotspot was also investigated through technique. Molecular dynamics performed determine binding stability docked complexes. Absorption,...
Colistin (polymyxin E) is widely used in animal and human medicine increasingly as one of the last-resort antibiotics against Gram-negative bacilli. Due to increased use colistin treating infections caused by multidrug-resistant bacteria, resistance this antibiotic ought be monitored. The study was undertaken elucidate molecular mechanisms, genetic relationships phenotype correlations colistin-resistant isolates. Here, we report detection mcr-1 gene chicken-associated Salmonella isolates...
Cortex Phellodendri (C. Phellodendri), the dried trunk bark of Phellodendron amurense Ruprecht, has been known as a traditional herbal medicine, showing several bioactivities. However, antiviral activity C. aqueous extract (CP) not reported in detail, particularly aiming prophylactic effectiveness.In vitro CP evaluated against Influenza A virus (PR8), Vesicular Stomatitis Virus (VSV), Newcastle Disease (NDV), Herpes Simplex (HSV), Coxsackie (H3-GFP) and Enterovirus-71 (EV-71) infection on...
FAS-associated factor-1 (FAF1) is a component of the death-inducing signaling complex involved in Fas-mediated apoptosis. It regulates NF-κB activity, ubiquitination, and proteasomal degradation. Here, we found that FAF1 positively type I interferon pathway. FAF1gt/gt mice, which deficient FAF1, knockdown immune cells were highly susceptible to RNA virus infection showed low levels inflammatory cytokines (IFN) production. was bound competitively NLRX1 regulated IFN by interfering with...
Zoonotic and antimicrobial-resistant Escherichia coli (hereafter, E. coli) is a global public health threat which can lead to detrimental effects on human health. Here, we aim investigate the antimicrobial resistance presence of mcr-1 gene in isolated from chicken feces. Ninety-four isolates were obtained samples collected different locations Bangladesh, identified using conventional microbiological tests. Phenotypic disk diffusion tests 20 agents performed according CLSI-EUCAST guidelines,...
Inadequate handling of raw meat leading to cross-contamination, often stemming from insufficient knowledge and practices among handlers, poses a significant global health challenge, especially in developing nations where food-borne diseases are prevalent. Effective understanding implementation preventive measures by handlers essential reducing the incidence illnesses contamination meat. This study aimed assess knowledge, attitudes, regarding hygiene retail sellers slaughterhouse personnel...
Multidrug-resistant Vibrio parahaemolyticus has become a significant public health concern. The development of effective drugs and vaccines against is the current research priority. Thus, we aimed to find out drug vaccine targets using comprehensive genome-based analysis. A total 4822 proteins were screened from V. proteome. Among 16 novel cytoplasmic proteins, 'VIBPA Type II secretion system protein L' Putative fimbrial Z' subjected molecular docking with 350 human metabolites, which...
Abstract Postinfluenza bacterial pneumonia is a significant cause of hospitalization and death in humans. The mechanisms underlying this viral synergy remain incompletely understood. Recent evidence indicates that influenza-induced IFNs, particularly type I IFN (IFN-I) IFN-γ, suppress antibacterial defenses. In study, we have investigated the relative importance interplay IFN-I IFN-γ pathways susceptibility to Streptococcus pneumoniae infection. Using gene-deficient mouse models, as well...
Aim: To develop emerging diagnostic technique for bovine tuberculosis and to identify its potential risk factors. Materials & methods: Bacterial genomic DNA was isolated from milk human sputum samples subjected PCR using specific primer pairs. results were validated bacteriological cultures. Results: amplification of the targeted fragment Mycobacterium bovis successful in 12.33% (37/300) samples. Interestingly, 500-bp also amplified 6.67% (6/90) indicating possibility zoonotic transmission....
Foot-and-mouth disease virus (FMDV) is a single-stranded, positive-sense RNA containing at least 13 proteins. Many of these proteins show immune modulation capabilities. As non-structural protein the FMDV, 2B involved in rearrangement host cell membranes and disruption secretory pathway as viroporin. Previous studies have also shown that FMDV plays role type-I interferon (IFN) responses through inhibition expression RIG-I MDA5, key cytosolic sensors IFN signaling. However, exact molecular...
Foot and mouth disease (FMD) is a highly contagious devastating viral among all cloven-footed animals. In Bangladesh, the endemic, with outbreaks occurring throughout year in haor regions. Thus, FMD impact livelihoods area are of great concern. Therefore, cross-sectional study was undertaken to evaluate prevalence, distribution, risk factors for clinical some selected areas Sylhet division Bangladesh. We examined 1,388 cattle, which 343 were clinically affected (prevalence 24.71%, CI95% =...