A5055746049- Viral Infections and Vectors
- Rabies epidemiology and control
- Zoonotic diseases and public health
- Video Analysis and Summarization
- CRISPR and Genetic Engineering
- Antibiotic Resistance in Bacteria
- Video Coding and Compression Technologies
- Pluripotent Stem Cells Research
- interferon and immune responses
- Advanced Data Compression Techniques
- Bone Tissue Engineering Materials
- RNA Interference and Gene Delivery
- Multimedia Communication and Technology
- Consumer Perception and Purchasing Behavior
- Multilevel Inverters and Converters
- Mesenchymal stem cell research
- Algorithms and Data Compression
- Blood properties and coagulation
- Context-Aware Activity Recognition Systems
- Kruppel-like factors research
- Genomics and Phylogenetic Studies
- Aquaculture disease management and microbiota
- Herpesvirus Infections and Treatments
- Advanced DC-DC Converters
- Advanced Vision and Imaging
Seoul National University
2014-2024
Hanbat National University
2023-2024
Pukyong National University
2024
Gachon University
2023
Ajou University
2019-2023
Tohoku University
2023
Korea University
2023
Chungnam National University
2017-2021
Yonsei University
2018-2021
Zero to Three
2016
Tissue engineering is an interdisciplinary field that attempts to restore or regenerate tissues and organs through biomimetic fabrication of scaffolds with specific functionality. In recent years, graphene oxide (GO) considered as promising biomaterial due its nontoxicity, high dispersity, hydrophilic interaction, these characteristics are key stimulating the interactions between substrates cells.
KRAS is the most frequently mutated oncogene in human tumors, and its activating mutations represent important therapeutic targets. The combination of Cas9 guide RNA from CRISPR-Cas system recognizes a specific DNA sequence makes double-strand break, which enables editing relevant genes. Here, we harnessed CRISPR to specifically target mutant alleles cancer cells. We screened RNAs using reporter validated them cells after lentiviral delivery RNA. survival, proliferation, tumorigenicity vitro...
Abstract We have reported that autophagy is crucial for clearance of amyloidogenic human IAPP (hIAPP) oligomer, suggesting an enhancer could be a therapeutic modality against diabetes with amyloid accumulation. Here, we show recently identified (MSL-7) reduces hIAPP oligomer accumulation in induced pluripotent stem cell-derived β-cells (hiPSC-β-cells) and diminishes oligomer-mediated apoptosis β-cells. Protective effects MSL-7 β-cell death are significantly reduced cells knockout MiTF/TFE...
ARSs are essential enzymes in translation that link specific amino acids to their cognate tRNAs. In higher eukaryotes, some possess additional, noncanonical functions the regulation of cell metabolism. Here, we report a novel function WRS antiviral defense. is rapidly secreted response viral infection and primes innate immune by inducing secretion proinflammatory cytokines type I IFNs, resulting inhibition virus replication both vitro vivo . Thus, consider be member response. The results...
Abstract Infection of hepatitis B virus (HBV) increase the incidence chronic liver disease and hepatocellular carcinoma (HCC). The viral x (HBx) protein encoded by HBV genome contributes to pathogenesis HCC thus, negative regulation HBx is beneficial for alleviation pathogenesis. MARCH5 a mitochondrial E3 ubiquitin ligase here, we show that high expression levels are correlated with improved survival in patients. interacts mainly accumulated mitochondria targets it degradation. N-terminal...
Li, Na, and K metal anodes are the most promising for post Li ion batteries because of their low redox potential high specific capacity. However, alkali metals suffer from dendritic growth market price, which hinder commercialization anode batteries. For this reason, multivalent anodes, such as Mg, Ca, Al, considered alternatives to due uniform, less abundance in Earth's crust. Furthermore, deposition/stripping reactions require two or more electrons, enable volumetric Recent research has...
Abstract Proteus mirabilis is a commensal bacterium dwelling in the gastrointestinal (GI) tract of humans and animals. Although New Delhi metallo-β-lactamase 1 (NDM-1) producing P. emerging as threat, its epidemiology our society remains largely unknown. LHPm1, first isolate harboring NDM-1, was detected from companion dog that resides with human owner. The whole-genome study revealed 20 different antimicrobial resistance (AMR) genes against various classes agents, which corresponded to MIC...
Lumpy skin disease (LSD) is one of the most important emerging transboundary diseases. Recently, LSD has emerged in many countries northern hemisphere. The virus a huge genome and highly resistant to environmental conditions. also host-specific large ruminants, such as cattle domestic water buffalo, are particularly susceptible. In addition, wild ruminants can serve potential reservoirs for spreading virus. emergence might be related climate change various regions because an arthropod-borne...
Probiotics, prebiotics, and synbiotics are known to improve aquatic animals' growth health conditions. In this study, we investigated the effect of Bacillus sp. KRF-7 (KRF-7), PM8313 (PM8313), β-glucooligosaccharide (BGO), their on growth, digestive physiology, immunity, gut microbiota abalone, Haliotis discus hannai. The control diet (CON) was sprayed with 108 CFU/g (PRO1) or (PRO2) as probiotics, 0.10% BGO (PRE) prebiotic, combinations (SYN1: PRO1 + BGO; SYN2: PRO2+ BGO) synbiotic...
4D is an irresistible new trend in movie industry. Also the Digital Cinema technology pervasive most of theatre system. They provide movies streaming way to theatres simultaneously. We present a framework for service with sensory effect bring 4-D entertainment home based on MPEG-V standard. A complete can be supported from authoring effects environment description and commanding rendering devices by couple other standards. Now standard are ready contents users home.
The importance of transglutaminase 2 (TG2) in angiogenesis has been highlighted recent studies, but other roles this multi-functional enzyme endothelial cell (EC) function still remains to be fully elucidated. We previously showed that the extracellular TG2 is involved maintaining tubule formation ECs by a mechanism involving matrix-bound vascular growth factor (VEGF) signalling. Here, using and fibroblast co-culture 3D culture models, we demonstrate further role for both loss, which...
Advances in media technologies brought 3-D TV home and 4-D movies to your neighbour. We present a framework for broadcasting bring entertainment based on MPEG-V standard. A complete from authoring of sensory effects environment description commanding rendering devices the can supported by couple other standards. Part 2 provides tools describing capabilities sensors, part 3 describe effects, 5 actually interact with sensors.
Transglutaminase (TG) is a family of enzymes that catalyzes cross-linking reactions among proteins. Using fluorescent-labeled highly reactive substrate peptides, we recently developed system to visualize isozyme-specific in situ enzymatic activity. In the present study, investigated activities TG1 (skin-type) and TG2 (tissue-type) using whole mouse sections various embryonic developmental stages neonates. each case, also successfully used immunostaining identical for protein expression after...
Home appliance manufacturers have recently been trying to provide smart products capable of various Internet services. For example, one health care manufacturer provides a Wi‐Fi‐capable scale. Once users register their information with the manufacturer's server, weight and body fat records are automatically uploaded server whenever they measure weight. The can then watch check log easily using device, such as smartphone or tablet. One biggest problems, however, is that initial configuration...
Carbapenemase-producing Klebsiella pneumoniae (CPKP) is one of the most dangerous multidrug-resistant (MDR) pathogens in human health due to its widespread circulation nosocomial environment. CPKP carried by companion dogs, which are close beings, should be considered a common threat public health. However, dissemination through animals still under consideration major diagnosis and surveillance systems.Two isolates were genotyped harbor bla NDM-5-encoding IncX3 plasmids, subjected...
Abstract Based on the current situation of Korean culture and society, population companion animals in South Korea is growing rapidly along with zoonotic risks. The data regarding infections dogs reported sparse. This study aims to investigate seroprevalence seven potential pathogens Korea: Anaplasma phagocytophilum , Borrelia burgdoferi Ehrlichia canis Coxiella burnetii Brucella Leptospira spp . canine influenza A virus. total 284 serum samples were collected from 2018 2021, immunoglobulin...
Abstract The NLRP3 inflammasome is a global immune-sensor that activated by repertoire of endogenous and exogenous stimuli. translocates to mitochondria but whether involvement in the assembly unclear. Here, we show mitochondrial E3 ligase MARCH5 key regulator assembly. Myeloid cell-specific March 5 conditional knockout ( March5 cKO) mice exhibited an attenuated mortality rate upon LPS or Pseudomonas aeruginosa challenge. Macrophages derived from cKO failed secrete IL-1β IL-18 after...
Abstract The circulation of carbapenemase-producing Escherichia coli (CPEC) in our society is a serious concern for vulnerable patients nosocomial environments. However, the genomic epidemiology CPEC bacteria among companion animals remains largely unknown. In this study, epidemiological analysis was conducted using complete genome identification ST410 isolates obtained from animals. To estimate distance and relatedness isolates, total 37 whole-genome datasets E. strains were downloaded...
Vasohibin-2 (VASH2), a homologue of vasohibin-1 (VASH1), is overexpressed in various cancer cells and promotes tumor progression. We therefore regard VASH2 as molecular target for treatment. Here we applied vaccine technology to develop therapy against VASH2. selected two amino acid sequences protein; the MTG RRR peptides, which contain possible B cell epitopes. These are identical between human murine proteins distinct from those VASH1 protein. conjugated these peptides with carrier protein...
Combination of multiplication-free one-bit transform based block estimation with the diamond sparse search pattern is presented this paper. Unification patterns low-bit representation motion methods are rarely investigated and therefore approaches executed using full-search approach mostly. Our experiments show that such a combination can be carried out acceptable performance fall.