A5053561354- Mycobacterium research and diagnosis
- Neonatal Respiratory Health Research
- Pharmacological Effects of Natural Compounds
- Fungal Biology and Applications
- Platelet Disorders and Treatments
- Neuroendocrine Tumor Research Advances
- Superconducting Materials and Applications
- Phytochemical compounds biological activities
- Tuberculosis Research and Epidemiology
- Immune Response and Inflammation
- Cancer therapeutics and mechanisms
- Hemostasis and retained surgical items
- Renal Diseases and Glomerulopathies
- Neurogenetic and Muscular Disorders Research
- Inhalation and Respiratory Drug Delivery
- Periodontal Regeneration and Treatments
- Ion Transport and Channel Regulation
- Metabolism and Genetic Disorders
- Plant biochemistry and biosynthesis
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Nitric Oxide and Endothelin Effects
- 3D IC and TSV technologies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Signaling Pathways in Disease
Asahikawa Medical University
2013-2024
Tohoku University
2023
Kyowa Kirin (Japan)
2000-2022
National Hospital Organization
2022
Daiichi-Sankyo (Japan)
2016-2020
Juntendo University
2011-2020
Tokai University Hachioji Hospital
2019
Ohu University
2017
Taiyo Yuden (Japan)
2015
Fukushima Medical University
2010-2011
BackgroundThe study aim was, for the first time, to conduct a multicenter randomized controlled trial evaluate effect of tonsillectomy in patients with IgA nephropathy (IgAN).
Amino acid substitutions in human immunodeficiency virus type 1 (HIV-1) Gag cleavage sites have been identified HIV-1 isolated from patients with AIDS failing chemotherapy containing protease inhibitors (PIs). However, a number of highly PI-resistant variants lack site amino substitutions. In this study we multiple novel including L75R, H219Q, V390D/V390A, R409K, and E468K the protein at non-cleavage common among selected against following four PIs: amprenavir, JE-2147, KNI-272, UIC-94003....
Extrahepatic delivery of small interfering RNAs (siRNAs) may have applications in the development novel therapeutic approaches. However, reports on such approaches are limited, and scarcity concerning systemically targeted siRNAs with effective gene silencing activity presents a challenge. We herein report for first time CD206-targetable chemically modified mannose-siRNA (CMM-siRNA) conjugates to macrophages dendritic cells (DCs). CMM-siRNA exhibited strong binding ability CD206 selectively...
Background. Patients with IgA nephropathy (IgAN) often show aggravation of renal injury macroscopic hematuria after mucosal infections, especially tonsillitis. We previously demonstrated the important role Toll-like receptor 9 (TLR9) activation in pathogenesis murine IgAN. Moreover, a single nucleotide polymorphism (SNP) TLR9 was significantly associated pathological severity human In this study, we investigated correlations between tonsillar messenger RNA expression, SNP genotypes and...
HIV-1 Gag protein interaction with cyclophilin A (CypA) is critical for viral fitness. Among the amino acid substitutions identified in noncleavage sites variants resistant to protease inhibitors, H219Q (Gatanaga, H., Suzuki, Y., Tsang, Yoshimura, K., Kavlick, M. F., Nagashima, Gorelick, R. J., Mardy, S., Tang, C., Summers, and Mitsuya, H. (2002) J. Biol. Chem. 277, 5952-5961) H219P CypA binding loop confer greatest replication advantage HIV-1. These represent polymorphic residues. We found...
A 59-year-old man presented with refractory anemia, choreoathetosis in the left upper extremity, an unsteady gait and cognitive dysfunction. The laboratory findings showed a marked decrease ceruloplasmin. Magnetic resonance images revealed iron deposition brain visceral organs. Iron accumulation was also observed hepatocytes. Genetic analyses of ceruloplasmin gene novel homozygous mutation c.2185 delC exon 12. oral chelator deferasirox effective treating left-side gait. Providing early...
An efficient method for oligonucleotide-directed mutagenesis was developed to construct a set of site-specific mutations by using mixture oligodeoxyribonucleotides. With this method, as high 40% the tested clones turned out be desired mutants. Seven single-point mutants were isolated in "TATA" box region fibroin gene. In vitro transcription experiments showed that single-base transversions at TATA (A----T position -29, T----A or G -28, A----T -27, and -26) resulted decreased promoter...
A case of localized cavitary disease in lung with multiple isolations Mycobacterium terrae complex from the patient's sputum is presented. The past history and clinical tests supported his immunologic competency. Prolonged persistent positive led him to submit right lower lobe resection after 5 months chemotherapy. Innumerable isolates same mycobacteria resected cavity a compatible histopathologic finding as definitive etiologic agent this case.
It has been shown that a dinitrosyl dithiolato iron complex is formed under physiological conditions and it functions as an NO transporter. In the present study, diglutathionyl [DNIC-(GS)2] was injected into mice its abdominal distribution behavior were examined by using electron paramagnetic resonance (EPR) spectroscopy. The X-band EPR signal intensity of blood, liver, kidney, spleen decreased with time but signals from liver kidney readily detectable even 24h after injection. courses quite...
We presented a control strategy for tablet manufacturing processes based on continuous direct compression. The work was conducted by the experts of pharmaceutical companies, machine suppliers, academia, and regulatory authority in Japan. Among different items process, component ratio blended powder content were selected as requiring method specific to from conventional batch manufacturing. management Loss Weight (LIW) feeder deemed most important, Residence Time Distribution (RTD) model...
Immunoglobulin (Ig) G4-related sclerosing disease is a pathological concept proposed in Japan during the early 2000s. This lesion-forming may exhibit characteristics of systemic but often affects single organ. To date, IgG4-related mammary gland, or mastitis (IgG4-RM), has rarely been reported.Here, we describe case female patient who was admitted to our hospital with main complaints left breast and axillary lymphadenopathy. A careful diagnostic imaging examination led an initial suspicion...
A thin flip-chip (FC) BGA with a 65 nm device has been developed for the bottom package of on (PoP) packaging mobile equipment. The low-k interlayer dielectric (ILD) that is known to be fragile material, and substrate are connected by lead-free solder bumps in taking environmental safeguards into account. arranged 120 um pitch staggered array. height as low 0.85 mm (nom) was established 0.76 under development. To use this heights PoP total after stacking memory MCP result 1.4 (max). size 14...
Abstract The electrocatalytic activity of a 2,2,6,6‐tetramethylpipridine‐ N ‐oxyl (TEMPO)‐modified electrode toward the oxidation carbohydrates in phosphate buffer solution was investigated under neutral aqueous conditions at 25 °C. modified prepared on surface glassy carbon by electrochemical polymerization TEMPO precursor containing pyrrole side chain. Cyclic voltammetric studies showed that anodic peak current increased with concentration dose‐dependent manner.