A5057063303- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- HER2/EGFR in Cancer Research
- Breast Cancer Treatment Studies
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Cardiac pacing and defibrillation studies
- Breast Lesions and Carcinomas
- Liver Disease Diagnosis and Treatment
- Cardiac Arrhythmias and Treatments
- Cardiac Structural Anomalies and Repair
- Liver Disease and Transplantation
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Cancer Treatment and Pharmacology
- Infective Endocarditis Diagnosis and Management
- Cardiovascular and exercise physiology
- Cardiac Valve Diseases and Treatments
- Cardiac electrophysiology and arrhythmias
- Cancer Diagnosis and Treatment
- Advanced Breast Cancer Therapies
- Lung Cancer Treatments and Mutations
- Pulmonary Hypertension Research and Treatments
- Hemodynamic Monitoring and Therapy
- T-cell and B-cell Immunology
Nihon University
2016-2025
Gunma University
2023-2024
Nihon University Itabashi Hospital
2020-2024
EA Pharma (Japan)
2024
Tokai University
2011-2023
National Cancer Center Hospital East
2020
Tokai University Hachioji Hospital
2016-2019
Yokohama City University Medical Center
2017
Yokosuka Kyosai Hospital
2017
Yokohama Rosai Hospital
2017
The presence of tumor‐infiltrating lymphocytes ( TIL s) is associated with favorable long‐term outcome in breast cancer. However, little known about changes s during metastatic progression. To confirm our hypothesis that malignant tumors escape from the host immune system metastasis, we evaluated percentage paired samples primary and tumors. We retrospectively identified 25 patients human epidermal growth factor receptor‐2 HER 2 + , n = 14) triple negative TN 11) early cancer diagnosed...
Acute decompensated heart failure (ADHF) is often accompanied by liver congestion through increased right atrial pressure (RAP). Liver stiffness (LS) assessed non-invasively using transient elastography related to RAP and in patients with general HF. We investigated the relationship of LS clinical echocardiographic variables outcomes ADHF.Methods Results:The subjects were 105 ADHF admitted hospital between October 2016 June 2017. Patients divided into 2 groups based on median at admission...
Abstract Aims Lung ultrasound (LUS) may unmask occult heart failure with preserved ejection fraction (HFpEF) by demonstrating an increase in extravascular lung water (EVLW) during exercise. Here, we sought to examine the dynamic changes B-lines exercise identify optimal timeframe for HFpEF diagnosis. Methods and results Patients (n = 134) those without HF (controls, n 121) underwent a combination of stress echocardiography LUS simultaneous expired gas analysis EVLW. Exercise EVLW was defined...
Left atrial (LA) dysfunction is common in heart failure (HF) with preserved ejection fraction. However, data on the pathophysiologic impacts of impaired LA functional reserve remained limited. We sought to determine association abnormal dynamics during exercise cardiovascular reserve, capacity, and clinical outcomes.
Abstract Aims Exercise stress echocardiography (ESE) is often used to identify heart failure with preserved ejection fraction (HFpEF) in patients presenting dyspnea. However, diagnostic criteria have not been standardized. Here, we sought develop ESE-based diagnose HFpEF dyspneic patients. Methods and Results A total of 81 consecutive dyspnea who underwent exercise right catheterization ESE were evaluated. Diagnosis was ascertained by directly-measured hemodynamics (61 20 controls). Logistic...
Liver diseases drive the development and progression of atrial fibrillation (AF). The Fibrosis-4 (FIB4) index is a non-invasive scoring method for detecting liver fibrosis, but prognostic impact using it AF patients still unknown. Herein, we evaluated FIB4 as risk assessment tool cardiovascular events mortality in with AF.We performed post-hoc analysis prospective, observational multicenter study. A total 3067 enrolled Japanese registry were grouped first tertile (FIB4 < 1.75, n = 1022),...
Atrial fibrillation (AF) is a heterogeneous condition. We performed cluster analysis in cohort of patients with AF and assessed the prognostic implication identified phenotypes.We used two multicentre, prospective, observational registries AF: SAKURA registry (Real World Survey Fibrillation Patients Treated Warfarin Non-vitamin K Antagonist Oral Anticoagulants) (n=3055, derivation cohort) RAFFINE (Registry Japanese Focused on anticoagulant therapy New Era) (n=3852, validation cohort)....
The objective of this study was to examine the association between immunohistochemical Ki67 labeling index (IHC Ki67), mRNA expression level, and first-generation gene signatures in a cohort breast cancer patients. We assessed associations IHC panel 39 tumor samples, using an oligonucleotide microarray. Gene analyses included alone (MKi67), 21-gene signature, mitosis kinome score genomic grade index. Correlation coefficients were calculated by Spearman's rank correlation test. In all cases,...
Although the mouse heart failure (HF) model of hypertensive disease (HHD) is useful to investigate pathophysiology and new therapeutic targets for HHD, using simple experimental procedures stable phenotypes has not been established. This study aimed develop a novel HF HHD by combining salt loading uninephrectomy with ANG II infusion. Eight-week-old C57BL/6 male mice were treated infusion (AT), (AN), (AS), or infusion, uninephrectomy, (ANS). Systolic blood pressure was significantly elevated...
We have recently identified a second p53 -related p73L gene, also referred to as p63 / p51 p40 KET which encodes the 2 major isoforms and resulting from different exon usage at their amino terminal regions. Although are suspected play oncogenic tumour suppressive roles in mammalian cells, respectively, no evidence of linkage between expression these human cancers has been reported so far. In this study, we first investigated profile various cell lines found that novel isoform, termed...
To evaluate hormone receptors immunohistochemically, standardized staining procedures and scoring systems are required. The authors previously reported that highly sensitive affected basic factors for technical validation. aim of the present study was to show characteristics procedures. examine how enhance intensity increase positive cell population, two different methods were compared. systems, three systems--cell counting score, modified immunoreactive H score--were compared using same...
This 13-week, double-blind study was conducted to confirm the efficacy and safety of paliperidone palmitate (PP), at dosing regimens approved in other countries, Asian patients with schizophrenia.Asian (aged ≥20 years) diagnosed schizophrenia (Diagnostic Statistical Manual Mental Disorders, Fourth Edition-Text Revision criteria), having a Positive Negative Syndrome Scale (PANSS) total score 60 120 were enrolled randomized (1:1) PP or placebo group. Patients received intramuscularly...
Historically, humoral immunity was considered unimportant in anti-tumor immunity, and the differentiation activity of B cells breast cancer are poorly understood. However, it recently discovered that participate tumor through both antibody production immunosuppressive mechanisms. We analyzed expression B-cell markers detail using fluorescence-activated cell sorting to investigate relationship between subsets etiology. Blood samples were taken from patients healthy donors, peripheral blood...
Non-obese metabolic dysfunction-associated steatotic liver disease (MASLD) has been associated with cardiovascular-related mortality, leading to a higher mortality rate compared the general population. However, few reports have examined cardiovascular events in non-obese MASLD mouse models. In this study we created model mimic condition. involving seven-week-old C57BL/6J male mice, two dietary conditions were tested: standard high-fat/high-cholesterol diet (STHD-01) and combined of STHD-01...
Anemia is common in patients with heart failure preserved ejection fraction (HFpEF) and associated exercise intolerance. However, there are limited data on how anemia contributes to reduced capacity HFpEF. We aimed characterize capacity, cardiovascular ventilatory reserve, the oxygen (O2) pathway anemic HFpEF.A total of 238 HFpEF 248 dyspneic without HF underwent ergometry stress echocardiography simultaneous expired gas analysis. Patients were classified into two groups based presence...