A5006956543- Cardiovascular Function and Risk Factors
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Heart Failure Treatment and Management
- Cardiac Imaging and Diagnostics
- Cardiovascular and exercise physiology
- Pulmonary Hypertension Research and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiovascular Effects of Exercise
- Cardiac Valve Diseases and Treatments
- Cardiac tumors and thrombi
- Hemodynamic Monitoring and Therapy
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Cardiomyopathy and Myosin Studies
- Ultrasound in Clinical Applications
- Medical Imaging and Pathology Studies
- Coronary Artery Anomalies
- Mechanical Circulatory Support Devices
- Cancer Diagnosis and Treatment
- Congenital Diaphragmatic Hernia Studies
- Colorectal Cancer Treatments and Studies
- Kawasaki Disease and Coronary Complications
Gunma University
2010-2025
Gunma University Hospital
2020-2023
Rakuno Gakuen University
2019-2022
The Schwarzman Animal Medical Center
2021
Tokyo Women's Medical University
1994
Gifu Municipal Hospital
1989
City Hospital
1989
Exercise intolerance is a primary manifestation in patients with heart failure preserved ejection fraction (HFpEF) and associated abnormal hemodynamics poor quality of life. Two multiparametric scoring systems have been proposed to diagnose HFpEF. This study sought determine the performance H2FPEF HFA-PEFF scores for predicting exercise capacity echocardiographic findings intracardiac pressures during subjects dyspnea on exertion referred bicycle stress echocardiography. In subset,...
Background: Cardiac power output is a measure of cardiac performance, and its prognostic significance has been shown in heart failure (HF) with reduced ejection fraction. Patients HF preserved fraction may have altered but the relevance unknown. This study sought to determine association between clinical outcomes compare effect other measures performance including ventricular-arterial coupling mechanical efficiency. Methods: normalized left ventricular mass was assessed by echocardiography...
Abstract Aims Lung ultrasound (LUS) may unmask occult heart failure with preserved ejection fraction (HFpEF) by demonstrating an increase in extravascular lung water (EVLW) during exercise. Here, we sought to examine the dynamic changes B-lines exercise identify optimal timeframe for HFpEF diagnosis. Methods and results Patients (n = 134) those without HF (controls, n 121) underwent a combination of stress echocardiography LUS simultaneous expired gas analysis EVLW. Exercise EVLW was defined...
Left atrial (LA) dysfunction is common in heart failure (HF) with preserved ejection fraction. However, data on the pathophysiologic impacts of impaired LA functional reserve remained limited. We sought to determine association abnormal dynamics during exercise cardiovascular reserve, capacity, and clinical outcomes.
Abstract Aims Left ventricular (LV) diastolic dysfunction and heart failure with preserved ejection fraction (HFpEF) are common cardiac complications of patients systemic sclerosis (SSc). Exercise stress echocardiography is often used in symptomatic SSc to detect abnormal increases pulmonary pressures during exercise, but the pathophysiologic prognostic significance exercise assess presence HFpEF these unclear. Methods results Patients (n=140) underwent ergometry simultaneous expired gas...
Abstract Aims Exercise stress echocardiography (ESE) is often used to identify heart failure with preserved ejection fraction (HFpEF) in patients presenting dyspnea. However, diagnostic criteria have not been standardized. Here, we sought develop ESE-based diagnose HFpEF dyspneic patients. Methods and Results A total of 81 consecutive dyspnea who underwent exercise right catheterization ESE were evaluated. Diagnosis was ascertained by directly-measured hemodynamics (61 20 controls). Logistic...
Background Exercise-induced high heart rate may impair exercise tolerance by reducing diastolic filling time and ventricular in failure with preserved ejection fraction (HFpEF). Given the importance of chronotropic response, we hypothesized that reduction because exercise-induced increased would not cardiac output reserve capacity. We sought to determine association between rate, time, hemodynamics, capacity HFpEF. Methods Results Patients HFpEF (n=66) controls without HF (n=107) underwent...
Background: Identification of elevated pulmonary artery (PA) pressures during exercise may provide diagnostic, prognostic, and therapeutic implications in heart failure with preserved ejection fraction. Although widely performed, stress echocardiography underestimate true PA due to the difficulty estimating right atrial pressure (RAP) exercise. We hypothesized that peripheral venous (PVP) could allow for reliable estimation RAP, thus echocardiography. Methods: In protocol 1, we investigated...
Abstract Aims Heart failure with preserved ejection fraction (HFpEF) is a syndrome characterized by multiple cardiac reserve limitations during exercise. Cardiac power output (CPO) an index of global performance and can be estimated non-invasively echocardiography. We hypothesized that CPO exercise would associated impaired cardiovascular reserve, intolerance, adverse outcomes in HFpEF. Methods results Exercise stress echocardiography was performed 425 dyspnoeic patients [217 HFpEF 208...
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a hereditary disorder mostly caused by desmosome gene mutations. Recent comprehensive mutation analyses of Caucasian ARVC patients have revealed the presence not only single heterozygous mutation, but also compound and digenic heterozygosity. However, genetic basis Japanese remains poorly elucidated.The subjects were 7 definite 1 possible probands (6 males, 16-76 years age), their family members. Genetic screening for major...
Systemic metabolic impairment is the key pathophysiology of heart failure (HF) with preserved ejection fraction (HFpEF). Fatty acid-binding protein 4 (FABP4) highly expressed in adipocytes and secreted response to lipolytic signals. We hypothesized that circulating FABP4 levels would be elevated patients HFpEF, correlate cardiac structural functional abnormalities, could predict clinical outcomes.Serum measurements echocardiography were performed HFpEF (n = 92) those coronary artery disease...
Abstract Aims Right‐sided filling pressure is elevated in some patients with heart failure (HF) and preserved ejection fraction (HFpEF). We hypothesized that right atrial (RAP) would represent the cumulative burden of abnormalities left heart, pulmonary vasculature, heart. Methods results Echocardiography was performed 399 HFpEF. RAP estimated from inferior vena cava morphology its respiratory change [estimated (eRAP)], were divided according to eRAP (3 or ≥8 mmHg). Patients higher displayed...