A5083909742- Peripheral Artery Disease Management
- Cardiovascular Function and Risk Factors
- Coronary Interventions and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac Imaging and Diagnostics
- Vascular Procedures and Complications
- Heart Failure Treatment and Management
- Cerebrovascular and Carotid Artery Diseases
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Venous Thromboembolism Diagnosis and Management
- Aortic aneurysm repair treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Fibrosis and Remodeling
- Hormonal Regulation and Hypertension
- Diagnosis and Treatment of Venous Diseases
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Disease Prevention
- Renin-Angiotensin System Studies
- Cardiomyopathy and Myosin Studies
- Lipoproteins and Cardiovascular Health
- Pulmonary Hypertension Research and Treatments
Kansai Rosai Hospital
2017-2025
Osaka Police Hospital
2024
Kishiwada Tokushukai Hospital
2023
NTT (Japan)
2023
Hyogo Medical University
2004-2022
Osaka University
2005-2019
Nippon Medical School
2018
Yokohama City University Medical Center
2018
Yokohama City University
2018
Juntendo University Shizuoka Hospital
2018
Background: Despite recommendations in the guidelines and consensus documents, there has been no randomized controlled trial evaluating oral anticoagulation (OAC) alone without antiplatelet therapy (APT) patients with atrial fibrillation stable coronary artery disease beyond 1 year after stenting. Methods: This study was a prospective, multicenter, open-label, noninferiority comparing OAC to combined single APT among stenting 1:1 randomization fashion. The primary end point composite of...
Background — Recently, reactive oxygen species (ROS) have emerged as important molecules in cardiac hypertrophy. However, the ROS-dependent signal transduction mechanism remains to be elucidated. In this study, we examined role of an ROS-sensitive transcriptional factor, NF-κB, and a mitogen-activated protein kinase kinase, apoptosis signal-regulating 1 (ASK1), G-protein–coupled receptor (GPCR) agonist (angiotensin II, endothelin-1, phenylephrine)-induced hypertrophy isolated rat neonatal...
The caspase-8 homologue FLICE-inhibitory protein (FLIP) functions as a dominant negative, blocking apoptosis induced by the oligomerization of adapter FADD/MORT-1. FLIP expression correlates with resistance to various members tumor necrosis factor family such TRAIL. Furthermore, forced renders cells resistant Fas-mediated apoptosis. Although is regulated primarily MEK1 activity in activated T cells, oncogenic signaling pathways that regulate are largely unknown. In this report, we examined...
Macrophages differentiated from circulating peripheral blood monocytes are essential for host immune responses and have been implicated in the pathogenesis of rheumatoid arthritis atherosclerosis. In contrast to monocytes, macrophages resistant Fas-induced cell death by an unknown mechanism. FLICE (Fas-associated domain–like interleukin 1β–converting enzyme)–inhibitory protein (Flip), a naturally occurring caspase-inhibitory that lacks critical cysteine domain necessary catalytic activity,...
Objectives: Diastolic dysfunction that determines symptoms and prognosis in patients with systolic causes heart failure even the absence of dysfunction. Our recent studies have suggested myocardial stiffening is likely to play a crucial role triggering deleterious cardiac disorder. This study investigated differential contribution left ventricular (LV) hypertrophy fibrosis pressure-overloaded heart. Methods: Dahl-Iwai salt-sensitive rats fed on high-salt diet since 7 weeks transit congestive...
During myogenesis, proliferating myoblasts withdraw from the cell cycle, acquire an apoptosis-resistant phenotype, and differentiate into myotubes. Previous studies indicate that myogenic induction of cyclin-dependent kinase inhibitor p21 results in inhibition apoptotic death addition to its role as a negative cycle regulator. Here we demonstrate protein encoded by Akt proto-oncogene is induced C2C12 cells during differentiation with corresponding increase activity. In differentiating...
Background The efficacy of low-voltage-area (LVA) ablation has not been well determined. This study aimed to investigate the LVA in addition pulmonary vein isolation on rhythm outcomes patients with paroxysmal atrial fibrillation (AF). Methods and Results VOLCANO (Catheter Ablation Targeting Low-Voltage Areas After Pulmonary Vein Isolation Paroxysmal Atrial Fibrillation Patients) trial included AF undergoing initial ablation. Of 398 whom a left voltage map was obtained after isolation, 336...
Abstract —Fas is constitutively expressed on endothelial cells, but in contrast to smooth muscle and other cell types, cells are highly resistant Fas-mediated apoptosis. In this study, we examined the role of serine/threonine kinase Akt/PKB controlling sensitivity Serum deprivation inhibited expression caspase-8 inhibitor FLICE-inhibitory protein (FLIP), which functions downstream from Fas. FLIP levels were restored when serum-depleted treated with vascular growth factor. Treatment...
Matrix metalloproteinases (MMPs) are activated in dilated failing hearts, and angiotensin-converting enzyme (ACE) inhibition prevents left ventricular (LV) dilatation. However, it remains unclear whether activation of MMPs precedes or is secondary to LV remodeling, an effect ACE on unknown.Dahl salt-sensitive rats fed a high-salt diet from 8 weeks served as the hypertensive heart failure (HF) model. echo, histological study, measurement mRNA levels, gelatin zymography were performed before...
Objective There are two phenotypes of heart failure, systolic failure and isolated diastolic with preserved left ventricular function. Although frequently occurs, there only models for dysfunction unassociated overt have not been established. We attempted to develop different models, i.e. based on hypertension. Materials methods Dahl salt-sensitive rats were placed 8% NaCl diet from 7 weeks old (7-week starting group) or 8 (8-week group). As an age-matched control, consistently normal chow....
Background Chronic heart failure (CHF) with preserved left ventricular (LV) ejection fraction (HFpEF) is observed in half of all patients CHF and carries the same poor prognosis as reduced LV (HFrEF). In contrast to HFrEF, there no established therapy for HFpEF. inflammation contributes cardiac fibrosis, a crucial factor HFpEF; however, inflammatory mechanisms mediators involved development HFpEF remain unclear. Therefore, we sought identify novel this process. Methods Results An analysis by...
Endovascular aortic repair (EVAR) is performed in patients with thoracic or abdominal aneurysm because it less invasive than conventional open repair. However, the effects of EVAR on vascular and cardiac function remain to be clarified.We studied several outcome variables 40 consecutive undergoing for and/or preserved ejection fraction. Echocardiography brachial-ankle pulse wave velocity (baPWV) data were collected before, 1 week, year after EVAR. Although no changes blood pressure found,...
In-stent restenosis (ISR), especially for neoatherosclerosis, is still a major problem of percutaneous coronary intervention (PCI) even in the drug-eluting stent (DES) era.The purpose this study was to investigate impact neoatherosclerosis on prognosis after PCI ISR.Between March 2009 and December 2017, 313 ISR lesions patients undergoing an OCT-guided five hospitals were retrospectively enrolled. Neoatherosclerosis defined as lipid neointima or calcified neointima. We examined association...
Abstract Aims The purpose of this study was to compare the impact catheter ablation on cardiac structural reverse remodelling and atrial (AFMR) ventricular (VFMR) functional mitral regurgitation (MR), long‐term prognosis patients with AFMR VFMR. Methods results retrospective included persistent AF who had ( n = 136, left (LA) volume index >30 mL/m 2 (LV) ejection fraction ≥40%) or VFMR 31, LV <40% regional asynergy) undergone initial from April 2015 December 2019. Baseline 6 month...
BackgroundAtrial cardiomyopathy is known as an underlying pathophysiological factor in the majority of AF patients. Left atrial low-voltage areas (LVAs) are reported to coincide with fibrosis, and likely represent cardiomyopathy.ObjectiveThis study aimed delineate differences long-term prognosis patients stratified by size LVAs.MethodsThis observational included 1,488 consecutive undergoing initial ablation for AF. LVAs were defined regions a bipolar peak-to-peak voltage < 0.50 mV. The total...
Diastolic heart failure (DHF) has become a social burden; however, evidences leading to its therapeutic strategy are lacking. This study investigated effects of addition angiotensin II type 1 receptor blocker (ARB) angiotensin-converting enzyme inhibitor (ACEI) at advanced stage DHF in hypertensive rats. Dahl salt-sensitive rats fed 8% NaCl diet from age 7 weeks served as model, and those normal chow control. The model were arbitrarily assigned 3 treatment regimens 17 weeks: ACEI (temocapril...
Cardiac aldosterone levels have not been evaluated in diastolic heart failure (DHF), and its roles this type of remain unclear. This study aimed to detect cardiac by use a liquid chromatographic-mass spectrometric method assess the effects mineralocorticoid receptor blockade on hypertensive DHF. Dahl salt-sensitive rats fed 8% NaCl diet from 7 wk (hypertensive DHF model) were divided at 13 into three groups: those treated with subdepressor doses eplerenone (12.5 or 40 mg x kg(-1) day(-1)) an...
Abstract —The GATA-6 transcription factor is expressed in quiescent vascular smooth muscle cells (VSMCs) culture, and levels of its transcript are rapidly downregulated on mitogen stimulation. In this study, we demonstrate that the transcript, protein, DNA-binding activity rat carotid arteries balloon injury. Downregulation was detected at 1 3 days after injury recovered by 7 days. To assess role downregulation injury-induced lesion formation, adenoviral vectors were used to express...