A5038266195- Cardiac Imaging and Diagnostics
- Cardiac Ischemia and Reperfusion
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrest and Resuscitation
- Heart Failure Treatment and Management
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Acute Myocardial Infarction Research
- Nitric Oxide and Endothelin Effects
- Cardiovascular Health and Disease Prevention
- Electron Spin Resonance Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Peripheral Artery Disease Management
- Inflammatory mediators and NSAID effects
- Coronary Interventions and Diagnostics
- Biochemical effects in animals
- Electrolyte and hormonal disorders
- Cardiac Valve Diseases and Treatments
- Venous Thromboembolism Diagnosis and Management
- Advanced X-ray and CT Imaging
- Cardiovascular Disease and Adiposity
- Blood Pressure and Hypertension Studies
- Medical Imaging Techniques and Applications
Osaka City General Hospital
2022
Osaka Prefectural Medical Center
2022
Osaka University
1994-2007
Osaka Rosai Hospital
1998-2004
Saba University School of Medicine
1994-2000
Health First
1994-1998
Teijin (Japan)
1994-1995
Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences
1994
Sakurabashi Watanabe Hospital
1988
The infarct-limiting effect of ischemic preconditioning is believed to be a transient phenomenon. We examined the delayed effects repetitive brief ischemia on limiting infarct size in an open-chest dog model by occlusion (90 minutes) left anterior descending coronary artery (LAD) followed reperfusion (5 hours). dogs were preconditioned with four repeated episodes induced 5-minute LAD occlusions subsequent reperfusion. infarcts initiated sustained immediately or 24 hours after was...
Epidemiologic investigations have shown that exercise reduces morbidity and mortality from coronary artery disease. In this study, using a rat model, we attempted to determine whether can reduce ischemic injury the heart elucidate mechanism for cardioprotective effect of exercise. Results showed significantly reduced magnitude myocardial infarction in biphasic manner. The time course cardioprotection resembled change manganese superoxide dismutase (Mn-SOD) activity. administration antisense...
Manganese superoxide dismutase (Mn-SOD) is induced in ischemic hearts 24 h after preconditioning, when tolerance to ischemia acquired. We examined the relationship between Mn-SOD induction and protective effect of preconditioning using cultured rat cardiac myocytes. Exposure myocytes brief hypoxia (1 h) decreased creatine kinase release by sustained (3 that follows was applied hypoxic (57% cells without preconditioning). The activity content were increased (activity, 170%; content, 139%...
We examined antioxidant activity in the pre-conditioned canine myocardium with four 5-min episodes of regional ischemia and reperfusion. Immediately after repetitive brief ischemia, mitochondrial Mn-superoxide dismutase (SOD) ischemic significantly increased compared that nonischemic (18.7 +/- 2.1 vs. 14.9 1.0 U/mg protein, P < 0.05). Although no difference was seen between these regions 3 h sublethal a significant increase reappeared 24 (26.7 0.9 20.8 Mn-SOD content gradually peak (2.8...
Background —Hyperthermia increases cardiac tolerance to ischemia/reperfusion injury 24 hours after the heat stress. Free radicals and redox mechanisms have been implicated in such tolerance. However, time course its relation induction of antioxidative enzymes protection induced by whole-body hyperthermia against are unknown. Methods Results was anesthetized rats placement a temperature-controlled water bath. After defined recovery interval(s) at room temperature, ischemia occlusion left...
Background An association between uric acid (UA) and cardiovascular diseases, including heart failure (HF), has been reported. However, whether UA is a causal risk factor for HF controversial. In particular, the prognostic value of lowering in patients with preserved ejection fraction (HFpEF) unclear. Methods Results We enrolled HFpEF from PURSUIT‐HFpEF (Prospective Multicenter Observational Study Patients With Heart Failure Preserved Ejection Fraction) registry. investigated was correlated...
Abstract Aims The prevalence of left ventricular diastolic dysfunction increases with age, particularly in hypertensive women. We aimed to determine the age‐ and sex‐related differences function, its relation alterations cardiac dimensions a population. Methods results enrolled 479 patients ejection fraction (LVEF) ≥50% (men/women, 267/212) their echocardiographic parameters regarding LV performance vascular function were measured. Left atrial volume index (LAVI) operant elastance (EdI:...
Background —Angiotensin-converting enzyme (ACE) inhibitors are effective in the secondary prevention of ischemic heart disease, but they do not reduce rate restenosis. Vascular ACE activity culprit coronary lesions these patients, however, has never been quantified. Methods and Results —We measured vascular tissue obtained by directional atherectomy patients with acute syndrome (n=17) stable disease (n=36), without The was significantly increased (0.87±0.12 nmol · min –1 mg protein ; P...
We utilized a rat model of myocardial infarction to investigate whether manganese superoxide dismutase (Mn‐SOD), an intrinsic radical scavenger, and tumour necrosis factor‐ α (TNF‐α) and/or interleukin‐1β (IL‐1β) are involved in the late phase ischaemic preconditioning (IP). IP was induced anaesthetized rats by four 3‐min left coronary artery (LCA) occlusions, each separated 10 min reperfusion. Twenty‐four hours after repetitive brief ischaemia, LCA occluded for 20 followed reperfusion 48 h....
The role of nitric oxide (NO) in myocardial ischemia-reperfusion injury is still controversial. To determine the NO propagation a coronary artery occlusion-reperfusion model, we examined effect competitive synthase inhibitor, NG-nitro-L-arginine methyl ester (L-NAME), with and without L-arginine, on size infarct resulting from occlusion (30 min) followed by reperfusion (48 hr) rabbits. L-NAME (300 micrograms/kg, as bolus, 100 micrograms/kg/min, i.v.) L-arginine mg/kg, 10 mg/kg/min, was...
To define the relation between oxygen-derived free radical (oxy-radical) generation in reperfused ischemic myocardium and progression of myocardial damage, we measured oxy-radical propagating infarct size a model canine coronary occlusion (90 minutes) reperfusion. We used electron paramagnetic resonance spin-trapping techniques (5,5-dimethyl-1-pyrroline N-oxide [DMPO]) to detect oxy-radicals rapidly frozen samples taken by needle biopsy. There was no detectable DMPO adducts normal before or...
We previously reported that an index of afterload-related left ventricular diastolic function, operant elastance (Ed)/effective arterial (Ea) = E/e'/(0.9 × systolic blood pressure), was significantly higher in elderly hypertensive women. aimed to determine sex-related differences the E/e'-related indices for function and their related factors during admission patients with heart failure preserved ejection fraction (HFpEF).Elderly HFpEF women exhibit severe dysfunction associated different...
Background Modification of arrhythmogenic substrates with extensive ablation comprising linear and/or complex fractional atrial electrogram in addition to pulmonary vein isolation (PVI‐plus) can theoretically reduce the recurrence fibrillation. The DR‐FLASH score (score based on diabetes mellitus, renal dysfunction, persistent form fibrillation, left atrialdiameter >45 mm, age >65 years, female sex, and hypertension) is reportedly useful for identifying patients substrates. We...
The increased severity of the myocardial injury produced by coronary occlusion-reperfusion in models atherosclerosis is associated with an increase leukocyte accumulation ischemic myocardium. Expression P-selectin, adhesion molecule involved interaction between leukocytes and endothelium, atherosclerotic vessels. Long-term angiotensin-converting enzyme (ACE) inhibition has been shown to reduce vascular change experimental models.We examined changes size infarct resulting from...
Journal Article Free radical generation coupled with arachidonate lipoxygenase reaction relates to reoxygenation induced myocardial cell injury Get access Tsunehiko Kuzuya, Kuzuya Department of Pathophysiology and the First Medicine, Osaka University School Osaka, Japan: T S Hoshida, Y Kim, H Oe, M Hori, Kamada, Tada. Correspondence Dr Kuzuya. Search for other works by this author on: Oxford Academic PubMed Google Scholar Shiro Hoshida Youngjoon Kim Hiroshi Oe Masatsugu Hori Takenobu Kamada...
To assess how polymorphonuclear leukocytes (PMNs) act on coronary vasoactivity, we measured the changes in isometric tension of isolated rings canine arteries upon addition autologous PMNs to organ chambers which were suspended. When by colloidal polyvinylpyrrolidone-coated silica (Percoll) gradient method added chambers, ring preparations left circumflex developed tension. The increase was dependent amount (1 X 10(4) 5 10(6) cells/ml). Maximal obtained an optimal (5 10(5) cells/ml) almost...