A5072059967- Peripheral Artery Disease Management
- Coronary Interventions and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Cardiac electrophysiology and arrhythmias
- Aortic aneurysm repair treatments
- Vascular Procedures and Complications
- Diabetic Foot Ulcer Assessment and Management
- Cardiac pacing and defibrillation studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Aortic Disease and Treatment Approaches
- Cardiovascular Function and Risk Factors
- Venous Thromboembolism Diagnosis and Management
- Renal and Vascular Pathologies
- Cardiac Valve Diseases and Treatments
- Acute Ischemic Stroke Management
- Diagnosis and Treatment of Venous Diseases
- Electronic Packaging and Soldering Technologies
- Infective Endocarditis Diagnosis and Management
- Acute Myocardial Infarction Research
- Ubiquitin and proteasome pathways
- Balance, Gait, and Falls Prevention
- Cardiac Imaging and Diagnostics
- Injection Molding Process and Properties
Osaka University
2020-2025
Kansai Rosai Hospital
2015-2022
The University of Tokyo
2020
Shizuoka University
2016-2017
Yokohama National University
2016-2017
To investigate whether the severity of lesion calcification assessed by novel peripheral artery scoring system (PACSS) was associated with clinical outcomes after endovascular therapy (EVT) for superficial femoral (SFA) lesions.A retrospective analysis conducted 394 consecutive patients (mean age 72±8 years; 290 men) intermittent claudication [223 (57%) diabetes, 81 (21%) on hemodialysis] who underwent successful EVT de novo SFA lesions [length 152.1±95.7 mm; 199 (50%) TransAtlantic...
Background The efficacy of low-voltage-area (LVA) ablation has not been well determined. This study aimed to investigate the LVA in addition pulmonary vein isolation on rhythm outcomes patients with paroxysmal atrial fibrillation (AF). Methods and Results VOLCANO (Catheter Ablation Targeting Low-Voltage Areas After Pulmonary Vein Isolation Paroxysmal Atrial Fibrillation Patients) trial included AF undergoing initial ablation. Of 398 whom a left voltage map was obtained after isolation, 336...
Loss-of-function mutations in PKP2, which encodes plakophilin-2, cause arrhythmogenic cardiomyopathy (AC). Restoration of deficient molecules can serve as upstream therapy, thereby requiring a human model that recapitulates disease pathology and provides distinct readouts phenotypic analysis for proof concept gene replacement therapy. Here, we generated isogenic induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) with precisely adjusted expression plakophilin-2 from patient AC...
Background Stent thrombosis (ST) remains a significant medical issue. In particular, longer-term mortality and clinical predictors after ST occurrence have yet to be elucidated. Methods Results This was multicenter, retrospective, observational study. A total of 187 definite cases from January 2008 December 2017 were enrolled, the long-term outcomes investigated. The primary outcome measure cumulative occurrence. addition, independent assessed. Among stent types causing ST, bare-metal stent,...
ABSTRACT Background The long‐term valve durability of supra‐annular self‐expanding valves (SEV) and intra‐annular balloon‐expandable (BEV) in patients with small aortic annuli remains unexplored. Aims This study aimed to determine the bioprosthetic SEV versus BEV annuli. Methods retrospective included severe stenosis (AS) an annulus area 430 mm 2 or less who underwent transcatheter replacement using between October 2009 December 2022. Based on Valve Academic Research Consortium's three...
Purpose: To investigate the prognostic impact of infrapopliteal (IP) artery anatomic severity according to Global Limb Anatomic Staging System (GLASS) on delayed wound healing in patients with chronic limb-threatening ischemia (CLTI). Materials and Methods: This study retrospectively analyzed 639 limbs tissue loss 484 CLTI (mean age 74±10 years; 300 men) presenting IP lesions treated endovascular therapy between April 2010 December 2015. Two-thirds had diabetes (323, 67%) over half were...
ABSTRACT Background Paravalvular regurgitation (PVR) following transcatheter aortic valve replacement (TAVR) is a complication linked to poor outcomes. The prognostic impact of mild PVR, particularly in patients with elevated preprocedural left ventricular (LV) filling pressure, remains uncertain. Aims This study aimed assess the influence LV pressure on PVR prognosis TAVR. Methods single‐center, retrospective analyzed consecutive severe stenosis who underwent TAVR, excluding those moderate...
The latest Global Vascular Guidelines (GVG) recommend assessing the 2-year mortality risk in patients with chronic limb-threatening ischemia (CLTI) before revascularization. This study aimed to reveal whether Wound, Ischemia and foot Infection (WIfI) classification, developed originally as a assessment tool for limb prognosis, would be useful predicting CLTI era of GVG WIfI.
Aim: Although current guidelines recommend surgical revascularization as the first-line therapy for chronic total occlusion of abdominal aorta (Leriche syndrome), endovascular (EVT) has been increasingly utilized because development new technologies and techniques. EVT demonstrated durable midterm outcomes aortoiliac occlusive disease (AIOD). Nonetheless, little is known regarding their long-term predictors restenosis.
A recently introduced grid mapping catheter (GMC) is designed for better electrode-tissue contact and can collect bipolar signals both along across the splines, which may allow more efficient voltage map generation independent of propagation direction. We compared GMC with a conventional circular (CMC) left atrial (LA) mapping.This study included 20 consecutive patients undergoing repeat ablation recurrent fibrillation who had demonstrated LA low-voltage areas (LVAs, <0.10 mV). Following...
The prevalence of atrial fibrillation (AF) increases with age. Although the efficacy cryoballoon ablation (CB-A) in patients AF has been demonstrated, data on this CB-A elderly are limited. aim study was to evaluate 1-year and safety aged ≥80 years compared those less than 80 years.A total 49 consecutive paroxysmal (PAF) who underwent were 241 <80 years. AF-free survival rate at 1 year procedural between groups.Median (25th, 75th quartile) age 83 (82, 85) older group 68 (61, 73) younger...
Abstract Background Smaller low‐voltage areas (LVAs) obtained by multielectrode catheters were reported than those linear ablation catheters. However, the underlying electrogram difference has not been elucidated. This study aimed to compare two mapping catheters’ measurements of waveforms and LVAs. Methods prospective observational included 17 consecutive patients undergoing for persistent atrial fibrillation. Following pulmonary vein isolation, voltage during sinus rhythm was performed...
Background: The Δ160E mutation in TNNT2 , which encodes troponin T, is a rare pathogenic variant identified patients with hypertrophic cardiomyopathy and associated poor prognosis. Thus, convenient human model recapitulating the pathological phenotype caused by required for therapeutic development. Methods: We heterozygous in-frame deletion (c.478_480del, p.Δ160E) patient familial showing progressive left ventricular systolic dysfunction, leading to advanced heart failure. To investigate...
Study investigators encountered a female Becker muscular dystrophy (BMD) carrier with advanced heart failure (HF) and identified stop-gain variant in procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (PLOD3) as potential second-hit variant. Isogenic induced pluripotent stem cells (iPSCs) dominant expression of WT-DMD, Δ45-48-DMD, or Δ45-48-DMD corrected PLOD3 were established. Microforce testing using 3-dimensional self-organized tissue rings (SOTRs) generated from iPSC-derived...
Detection of yellow plaques (YP) by coronary angioscopy (CAS) 1 year after 1st-generation drug-eluting stent (DES) implantation has been related to future events. However, the association between CAS findings and clinical outcomes following 2nd-generation DES not investigated. Methods Results: This study included a total 248 in 179 patients, who were examined 9±2 months implantation. Angioscopic evaluation dominant neointimal coverage (NIC) grade, heterogeneity NIC, presences YP intrastent...
The purpose of this study was to elucidate the effect temporal relationship between atrial fibrillation (AF) and heart failure (HF) on clinical outcomes after catheter ablation.