A5102808169- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Heart Failure Treatment and Management
- Cardiac pacing and defibrillation studies
- Infective Endocarditis Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Hormonal Regulation and Hypertension
- Advanced MRI Techniques and Applications
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiovascular Health and Disease Prevention
- Cardiac electrophysiology and arrhythmias
- Pulmonary Hypertension Research and Treatments
- Aortic Disease and Treatment Approaches
- Cardiomyopathy and Myosin Studies
- Aortic Thrombus and Embolism
- Cardiovascular Disease and Adiposity
- Cardiac Ischemia and Reperfusion
- Venous Thromboembolism Diagnosis and Management
- Vibrio bacteria research studies
- Acute Myocardial Infarction Research
- Coronary Artery Anomalies
- Aortic aneurysm repair treatments
Osaka University
2012-2024
Takeda (Japan)
2005-2023
Osaka Police Hospital
2004-2020
Osaka University Hospital
2015
Bioengineering Center
2014
Itron (United States)
2014
National Cancer Registry
2014
American Heart Association
2014
University of Toyama
2013
Fukuda Denshi (Japan)
2007
In aortic regurgitation (AR), energy loss (EL) produced by inefficient turbulent flow may be a burden to the heart predicting decompensation. We attempted quantify EL in AR induced an acute dog model and patients with chronic using novel echocardiographic method vector mapping (VFM). 11 anaesthetized open-chest dogs, was distorting valve pigtail catheter, totally 20 cases. Regurgitant fraction determined pulsed Doppler echocardiography, <30% considered mild moderate (Group 1, n = 11) ≥30%...
Background Chronic heart failure (CHF) with preserved left ventricular (LV) ejection fraction (HFpEF) is observed in half of all patients CHF and carries the same poor prognosis as reduced LV (HFrEF). In contrast to HFrEF, there no established therapy for HFpEF. inflammation contributes cardiac fibrosis, a crucial factor HFpEF; however, inflammatory mechanisms mediators involved development HFpEF remain unclear. Therefore, we sought identify novel this process. Methods Results An analysis by...
Endovascular aortic repair (EVAR) is performed in patients with thoracic or abdominal aneurysm because it less invasive than conventional open repair. However, the effects of EVAR on vascular and cardiac function remain to be clarified.We studied several outcome variables 40 consecutive undergoing for and/or preserved ejection fraction. Echocardiography brachial-ankle pulse wave velocity (baPWV) data were collected before, 1 week, year after EVAR. Although no changes blood pressure found,...
Cardiac aldosterone levels have not been evaluated in diastolic heart failure (DHF), and its roles this type of remain unclear. This study aimed to detect cardiac by use a liquid chromatographic-mass spectrometric method assess the effects mineralocorticoid receptor blockade on hypertensive DHF. Dahl salt-sensitive rats fed 8% NaCl diet from 7 wk (hypertensive DHF model) were divided at 13 into three groups: those treated with subdepressor doses eplerenone (12.5 or 40 mg x kg(-1) day(-1)) an...
Distal protection, in the Saphenous Vein Graft Angioplasty Free of Emboli (SAFER) trial, is demonstrated to prevent distal embolism percutaneous coronary intervention saphenous vein graft. However, Enhanced Myocardial Efficacy and Recovery by Aspiration Liberated Debris (EMERALD) it was not effective native arteries patients with acute myocardial infarction (AMI). We hypothesized that its effectiveness would be determined lesion characteristics. Therefore, we classified type culprit...
Background Elevated plasma glucocorticoid level is an independent predictor of increased mortality risk in chronic heart failure, but local biosynthesis and pathophysiological roles glucocorticoids the remain unclear. Methods Dahl salt-sensitive rats on high-salt diet mice with transthoracic aortic banding (TAC) operation (TAC mice), both which finally represent were assessed at compensatory hypertrophic stage. As a model cardiac-specific activation steroidogenesis, α-myosin heavy...
AimsLeft ventricular (LV) fibrosis and stiffening play crucial roles in the development of heart failure with preserved ejection fraction (HFPEF). Plasma level digitalis-like factors (DLFs) is increased patients hypertension, a principal underlying cardiovascular disease HFPEF. Digitalis-like inhibit ion-pumping function Na+/K+-ATPase activate Ca2+ entry mode Na+/Ca2+ exchanger (NCX). are known to promote collagen production fibroblasts. The aim this study was explore whether pharmacological...
Although the mouse heart failure (HF) model of hypertensive disease (HHD) is useful to investigate pathophysiology and new therapeutic targets for HHD, using simple experimental procedures stable phenotypes has not been established. This study aimed develop a novel HF HHD by combining salt loading uninephrectomy with ANG II infusion. Eight-week-old C57BL/6 male mice were treated infusion (AT), (AN), (AS), or infusion, uninephrectomy, (ANS). Systolic blood pressure was significantly elevated...
Angiotensin II type 1 receptor blocker (ARB) is increasingly prescribed for the treatment of systolic heart failure with a growing body clinical evidence. The roles ARB, however, remain to be clarified in diastolic (DHF), particularly at its advanced stage. This experimental study investigated effects ARB administered an stage hypertensive DHF.Dahl salt-sensitive rats fed 8% NaCl diet from age 7 weeks represent overt DHF 20 weeks, as noted previous studies (hypertensive model). model were...
Transcatheter aortic valve replacement (TAVR) is a new alternative treatment with acceptable early results for patients stenosis considered to be inoperable. The first TAVR was performed in Japan October 2009, and total of 51 have been up February 2012.Because it not possible disclose details 36 at the time writing due ongoing clinical trials, mid-term 15 are presented Edwards SAPIEN valves. Age 83.4 ± 6.1 years. Mean pressure gradient area were 60.3 21.1 mmHg 0.64 0.19 cm(2), respectively....
Background The management of mixed aortic valve disease (MAVD), defined as the concomitant presence stenosis (AS) and regurgitation, remains a clinical challenging. present study assessed impact transcatheter replacement (TAVR) on cardiac geometry prognosis in patients with MAVD. Methods Results A retrospective multicenter TAVR registry was conducted, including who underwent for severe symptomatic AS between January 2015 March 2019. Patients were subdivided into 2 groups according to...
Background: Systolic abnormality, as well diastolic dysfunction, is observed in patients with heart failure preserved ejection fraction (HFPEF). However, the role of these 2 conditions transition from asymptomatic dysfunction to symptomatic remains unclear. We recently demonstrated that wall strain (DWS) inversely correlates myocardial stiffness constant. Methods and Results: This study consisted 127 subjects: 52 consecutive HFPEF (HFPEF group), 50 hypertensive ≥50% whose age, gender left...
Although transcatheter aortic valve replacement (TAVR) has demonstrated favorable outcomes in randomized studies, there remains a sizable group of patients whom TAVR may be futile. Characterizing the survival rate wide array undergoing can help develop effective strategies for improving allocation medial resources.