A5101655575- Neurological disorders and treatments
- Neuroendocrine regulation and behavior
- Neuroscience of respiration and sleep
- Infant Health and Development
- Botulinum Toxin and Related Neurological Disorders
- Transcranial Magnetic Stimulation Studies
- Genetic Neurodegenerative Diseases
- Pain Mechanisms and Treatments
- Muscle activation and electromyography studies
- Cardiac Imaging and Diagnostics
- Stress Responses and Cortisol
- Parkinson's Disease Mechanisms and Treatments
- Motor Control and Adaptation
- Heart Rate Variability and Autonomic Control
- Sodium Intake and Health
- Ion Channels and Receptors
- Cardiac Arrhythmias and Treatments
- Blood Pressure and Hypertension Studies
- Cerebral Palsy and Movement Disorders
- Heart Failure Treatment and Management
- Cardiac electrophysiology and arrhythmias
- Human-Animal Interaction Studies
- Atrial Fibrillation Management and Outcomes
- Ion channel regulation and function
- Esophageal and GI Pathology
Kyoto Katsura Hospital
2021-2025
Mirai Hospital
2021-2024
Kao Corporation (Japan)
2016-2023
National Center of Neurology and Psychiatry
2008-2022
Kumamoto City Hospital
2021
Neurology, Inc
2020
Azabu University
2019-2020
Fukuyama City Hospital
2014-2019
Princess Margaret Cancer Centre
2019
Gunma University
2017
The skin epidermis is densely innervated by peripheral sensory nerve endings. Nociceptive neurons, whose terminals are in close contact with epidermal keratinocytes, can be activated directly noxious physical and chemical stimuli to trigger pain. However, whether keratinocytes signal acutely initiate pain vivo remains unclear. Here, using the keratin 5 promoter selectively express capsaicin receptor TRPV1 of TRPV1-knockout mice, we achieved specific stimulation capsaicin. Using this...
The administration of methimazole is known to induce cell death in rat olfactory receptor neurons (ORNs). We investigated whether this injury occurs via apoptosis or through necrosis and it involves the extrinsic intrinsic pathway. Rats were intraperitoneally injected with vehicle (control) 300 mg/kg methimazole. experimental animals also administered a caspase-3 caspase-9 inhibitor 30 min earlier. induced predominantly mature ORNs partially reduced sensitivity rats; injured cells...
ABSTRACT Background For delivering high radiation doses to pancreatic tumors, organ motion management is indispensable; however, studies on this are limited. We aimed evaluate the efficacy and safety of dynamic tumor tracking (DTT) moderately hypofractionated intensity‐modulated radiotherapy (IMRT) in patients with locally advanced cancer (LAPC). Methods Patients histological confirmation for LAPC were included. A linac system, which was mounted a gimbal function, used DTT‐IMRT. The...
Dystonia is a movement disorder characterized by abnormalities at multifaceted aspects of motor dexterity and neural functions. Evidence bridging between pathophysiology limited. A novel finding was that in focal task-specific dystonia (FTSD), an aberrantly reduced inhibition the cortex related to temporal imprecision dexterous finger movements, whereas elevated facilitation associated with abnormally sluggish transition movements from flexion extension. We newly identified two sets...
Abstract Two main neural mechanisms including loss of cortical inhibition and maladaptive plasticity have been thought to be involved in the pathophysiology focal task‐specific dystonia. Such likely correspond overactivity disorganized somatotopy, respectively. However, most plausible mechanism dystonia remains unclear. To address this question, we assessed brain activity somatotopic representations motor‐related areas using functional MRI behavioral measurement healthy instrumentalists...
To investigate whether nitric oxide (NO) contributes to the regulation of retinal circulation during hypercapnia in cats.NG-nitro-L-arginine-methylester (L-NAME; n=8), a NOS inhibitor; NG-nitro-D-arginine-methylester (D-NAME; n=6), inactive isomer; or phosphate-buffered saline (PBS; n=8) was injected intravitreously into cat's eye. A selective neuronal synthase (nNOS) inhibitor, 7-nitroindazole (7-NI; intraperitoneally. Hypercapnia induced for 10 minutes by inhalation 5% carbon dioxide with...
The objective of our study was to evaluate whether a low-dose contrast material (CM) protocol with saline flush might provide sufficient enhancement in aortoiliac 16-MDCT angiography.Forty-five patients were divided into two groups on the basis CM (300 mg I/mL) administration protocol: group 1 (23 patients) received 100 mL at 3.0 mL/sec; and 2 (22 patients), 50 mL/sec followed by 20-mL mL/sec. All underwent angiography entire region. Seven regions interest (ROIs) drawn from ascending aorta...
Objective The authors evaluated ileocolon interposition as a substitute stomach after total gastrectomy (TG) or proximal (PG). Summary Background Data Although the jejunum frequently is used for reconstruction to create TG PG, there are few reports on interposition. Methods performed in 47 patients who underwent (N = 18) PG 29) malignant gastric lesion and function of this structure using esophagoscopy, manometry, pH-metry, emptying time, oral glucose tolerance test (OGTT), postoperative...
Surfactant protein D (SP-D) is a lung-specific that synthesized and secreted by lung epithelial cells believed to play an important role in host defence. This belongs the C-type lectin family, which characterized N-terminal cysteine-rich domain, collagen-like neck domain carbohydrate recognition (CRD). To elucidate biological actions of this animal against such pathogens as micro-organisms, activities recombinant partial SP-D lacking were examined. A human SP-D, consisting short collagen...