A5092251584- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Advanced Proteomics Techniques and Applications
- Thermal Regulation in Medicine
- Nuclear Physics and Applications
- Cancer Immunotherapy and Biomarkers
- Urinary and Genital Oncology Studies
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Bladder and Urothelial Cancer Treatments
- Inflammatory Biomarkers in Disease Prognosis
Gdańsk Medical University
2023-2024
Male sex is a risk factor for colorectal cancer (CRC) with higher illness burden and earlier onset. Thus, we hypothesized that loss of chromosome Y (LOY) in the tumor micro-environment (TME) might be involved oncogenesis. Previous studies show LOY circulating leukocytes aging men was associated shorter survival non-hematological cancer, as well CD4 + T-lymphocytes prostate vs. controls. However, nothing known about infiltrating TME address this aspect here. We studied frequency functional...
Bladder urothelial carcinoma (BLCA) is the 10th most common cancer with a low survival rate and strong male bias. We studied field cancerization in BLCA using multi-sample- multi-tissue-per-patient protocol for sensitive detection of autosomal post-zygotic chromosomal alterations loss chromosome Y (LOY). analysed 277 samples histologically normal urothelium, 145 tumors 63 blood from 52 males 15 females, in-house adapted Mosaic Chromosomal Alterations (MoChA) pipeline. This approach allows...
Cold ischemia time (CIT), the interval between tissue excision and preservation, is a critical preanalytical variable that profoundly impacts gene expression profiles. Variability in CIT can lead to inconsistent transcriptomic results, making study interpretation challenging undermining reproducibility biomedical research. Our aimed evaluate impact of on cancer-related genes, particularly these involved hypoxia, apoptosis, epithelial-to-mesenchymal transition (EMT). We performed RNA...
Colorectal cancer (CRC) prognosis is determined by the disease stage with low survival rates for advanced stages. Current CRC screening programs are mainly using colonoscopy, limited its invasiveness and high cost. Therefore, non-invasive, cost-effective, accurate alternatives urgently needed.
Abstract Male sex is a risk factor for colorectal cancer (CRC) with higher illness burden and earlier onset. Thus, we hypothesized that loss of chromosome Y (LOY) in the tumor micro-environment (TME) might be involved oncogenesis. Previous studies show LOY circulating leukocytes aging men was associated shorter survival non-hematological cancer, as well CD4+ T-lymphocytes prostate vs. controls. However, nothing known about infiltrating TME address this aspect here. We studied frequency...